Redefining the pro-thrombotic mechanism of von Willebrand factor

重新定义血管性血友病因子的促血栓机制

• 批准号: nhmrc : GNT1143398
• 负责人: Prof Philip Hogg
• 金额: $ 75万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/redefining-pro-thrombotic-willebrand-factor/1348527
• 关键词: Redefining; pro; thrombotic; mechanism; von

Blood clotting is the underlying cause of heart attacks and strokes. The blood protein, von Willebrand factor, is a critical player in blood clotting and impairment of its function is life threatening. We have discovered that there are three forms of VWF in human blood that have different functions in blood clotting. Characterisation of these different forms will likely lead to new blood clotting diagnostics and improved therapies.

血液凝固是心脏病发作和中风的根本原因。血液蛋白，血管性血友病因子，是血液凝固的关键因素，其功能受损会危及生命。我们发现，人体血液中有三种形式的VWF，它们在凝血中具有不同的功能。这些不同形式的表征可能会导致新的凝血诊断和改进的疗法。