Imaging & Spectroscopy Core

影像学

• 批准号: 10357745
• 负责人: Narasimhan Rajaram
• 金额: $ 14.27万
• 依托单位: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10357745
• 关键词: Aging; Applications Grants; Arkansas; Award; Bioenergetics; Biological Models; Biology; Biomedical Research; Cell physiology; Cells; Cellular Metabolic Process; Centers of Research Excellence; Collaborations; Communities; Consultations; Data Analyses; Data Science; Data Science Core; Disease; Experimental Designs; Fostering; Foundations; Functional disorder; Funding; Future; Goals; Grant; Image; Image Analysis; Imaging Techniques; Imaging technology; Label; Light; Malignant Neoplasms; Medicine; Metabolic; Metabolism; Microscopy; Optics; Phase; Preparation; Publications; Research; Research Methodology; Research Personnel; Resolution; Resources; Role; Sampling; Services; Spectrum Analysis; Structure; Techniques; Technology; Tissues; Training; Translations; United States National Institutes of Health; Universities; Vision; Visualization; clinical translation; data acquisition; imaging approach; innovation; insight; instrument; interdisciplinary collaboration; member; metabolic imaging; novel; programs; spectroscopic imaging; synergism; temporal measurement; wound healing

Project Summary – Imaging and Spectroscopy Core Imaging is a major driver of discovery and translation in biology and medicine. The use of imaging and spectroscopic approaches can often provide insights that may not be available with other techniques that require sample processing. While an Imaging and Spectroscopy Core does not formally exist at the University of Arkansas, the key ingredients necessary to establish one are already present on campus. A range of optical microscopy and spectroscopy instruments are already available for use by other investigators, with several of these set up as service centers. These existing resources will be consolidated and expanded to establish an Imaging and Spectroscopy Core that will meet the research needs of the proposed Arkansas Integrative Metabolic Research Center (AIMRC), have long-term benefits for researchers at the University of Arkansas, and other campuses in the state and in this region of the U.S. The range of technologies available within the Core will allow project leaders to shed new light on cell and tissue metabolism, thus enabling novel discoveries as well as clinical translation of such discoveries. Close interaction between the Imaging and Spectroscopy Core and COBRE project leaders as well as the Data Science and Bioenergetics Cores will lead to new innovations in research methods that will benefit future COBRE investigators as well as the broader campus research community. Hands-on training in imaging technologies will be provided to Center members, the campus and biomedical researchers in Arkansas. The long-term goal of the Imaging Core is to develop and integrate advanced imaging approaches needed by AIMRC members and become fully independent of COBRE support by the end of Phase Ill. The short-term goal for COBRE Phase I is to provide state-of-the-art imaging techniques that can be incorporated into Center projects, develop new image analysis approaches in collaboration with project leaders and the Data Science Core that will support the long-term goal and provide support/educational opportunities to Center members. The specific aims of this proposal are to 1) Establish a state-of-the-art imaging and spectroscopy core at the University Arkansas that meets the needs of the COBRE project leaders and accelerates their progression to independence; 2) Identify and develop new applications of optical microscopy and spectroscopy on campus that synergize with the Bioenergetics and Data Science Cores and lay the foundation for long-term sustainability of the Center; and 3) Provide consultation and coordination, technical assistance and educational opportunities in support of experimental design, sample preparation, data acquisition and analysis, and preparation of high-quality figures for publications and grant applications related to imaging.

项目摘要-成像和光谱核心 成像是生物学和医学中发现和转化的主要驱动力。使用成像和 光谱方法通常可以提供其他技术可能无法提供的见解，这些技术需要 样品加工。虽然成像和光谱学的核心并不正式存在于加州大学 在阿肯色州，建立一所学校所需的关键要素已经出现在校园里。一系列光学 显微镜和光谱分析仪器已经可供其他研究人员使用，其中几个 这些都是作为服务中心设立的。这些现有资源将被合并和扩大，以建立一个 成像和光谱核心，将满足拟议的阿肯色州一体化的研究需求 代谢研究中心(AIMRC)，对阿肯色大学的研究人员有长期好处，以及 在该州和美国这一地区的其他校园。核心可用技术的范围 将使项目负责人对细胞和组织新陈代谢有新的了解，从而使新的发现成为可能 作为这些发现的临床翻译。成像与光谱岩心之间的密切作用 Cobre项目负责人以及数据科学和生物能量学核心将在 有利于未来Cobre研究人员以及更广泛的校园研究的研究方法 社区。将向中心成员、校园和 阿肯色州的生物医学研究人员。成像核心的长期目标是开发和集成 AIMRC成员需要的高级成像方法，并完全独立于Cobre支持 到伊利诺伊州阶段结束。Cobre第一阶段的短期目标是提供最先进的成像技术 可以整合到中心项目中，与 支持长期目标并提供支持/教育的项目负责人和数据科学核心 给中心会员的机会。这项提议的具体目标是1)建立最先进的成像技术 和光谱学核心，满足科布雷项目负责人和 加速他们走向独立；2)发现和开发光学显微镜的新应用 和光谱学，与生物能量学和数据科学核心协同工作，为 为中心的长期可持续性奠定基础；以及3)提供咨询和协调、技术 支持实验设计、样品制备、数据获取的援助和教育机会 和分析，并为与成像有关的出版物和赠款申请编制高质量的数字。