Imaging & Spectroscopy Core

影像学

• 批准号: 10574559
• 负责人: Narasimhan Rajaram
• 金额: $ 14.41万
• 依托单位: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10574559
• 关键词: Acceleration; Aging; Applications Grants; Arkansas; Award; Bioenergetics; Biological Models; Biology; Biomedical Research; Cell physiology; Cells; Cellular Metabolic Process; Centers of Research Excellence; Collaborations; Communities; Consultations; Data Analyses; Data Science; Data Science Core; Disease; Education; Experimental Designs; Fostering; Foundations; Functional disorder; Funding; Future; Goals; Grant; Image; Image Analysis; Imaging Techniques; Imaging technology; Label; Malignant Neoplasms; Medicine; Metabolic; Metabolism; Microscopy; Optics; Phase; Preparation; Publications; Research; Research Methodology; Research Personnel; Resolution; Resources; Role; Sampling; Services; Spectrum Analysis; Structure; Techniques; Technology; Tissues; Training; Translations; United States National Institutes of Health; Universities; Vision; Visualization; clinical translation; data acquisition; imaging approach; innovation; insight; instrument; interdisciplinary collaboration; member; metabolic imaging; novel; programs; synergism; temporal measurement; wound healing

Project Summary – Imaging and Spectroscopy Core Imaging is a major driver of discovery and translation in biology and medicine. The use of imaging and spectroscopic approaches can often provide insights that may not be available with other techniques that require sample processing. While an Imaging and Spectroscopy Core does not formally exist at the University of Arkansas, the key ingredients necessary to establish one are already present on campus. A range of optical microscopy and spectroscopy instruments are already available for use by other investigators, with several of these set up as service centers. These existing resources will be consolidated and expanded to establish an Imaging and Spectroscopy Core that will meet the research needs of the proposed Arkansas Integrative Metabolic Research Center (AIMRC), have long-term benefits for researchers at the University of Arkansas, and other campuses in the state and in this region of the U.S. The range of technologies available within the Core will allow project leaders to shed new light on cell and tissue metabolism, thus enabling novel discoveries as well as clinical translation of such discoveries. Close interaction between the Imaging and Spectroscopy Core and COBRE project leaders as well as the Data Science and Bioenergetics Cores will lead to new innovations in research methods that will benefit future COBRE investigators as well as the broader campus research community. Hands-on training in imaging technologies will be provided to Center members, the campus and biomedical researchers in Arkansas. The long-term goal of the Imaging Core is to develop and integrate advanced imaging approaches needed by AIMRC members and become fully independent of COBRE support by the end of Phase Ill. The short-term goal for COBRE Phase I is to provide state-of-the-art imaging techniques that can be incorporated into Center projects, develop new image analysis approaches in collaboration with project leaders and the Data Science Core that will support the long-term goal and provide support/educational opportunities to Center members. The specific aims of this proposal are to 1) Establish a state-of-the-art imaging and spectroscopy core at the University Arkansas that meets the needs of the COBRE project leaders and accelerates their progression to independence; 2) Identify and develop new applications of optical microscopy and spectroscopy on campus that synergize with the Bioenergetics and Data Science Cores and lay the foundation for long-term sustainability of the Center; and 3) Provide consultation and coordination, technical assistance and educational opportunities in support of experimental design, sample preparation, data acquisition and analysis, and preparation of high-quality figures for publications and grant applications related to imaging.

项目摘要-成像和光谱核心 成像是生物学和医学中发现和转化的主要驱动力。使用成像和 光谱方法通常可以提供用其他技术可能无法获得的见解， 样品处理虽然成像和光谱学核心并没有正式存在于大学， 阿肯色州，建立一个必要的关键因素已经在校园里。一系列光学 显微镜和光谱仪器已经可供其他研究人员使用，其中一些 这些都是服务中心。这些现有资源将得到巩固和扩大， 成像和光谱核心，将满足拟议的阿肯色州综合研究的研究需求 代谢研究中心（AIMRC），对阿肯色州大学的研究人员有长期的好处， 其他校园在国家和在美国的这个地区的核心内可用的技术范围 将使项目负责人能够对细胞和组织代谢进行新的研究，从而也能实现新的发现。 作为这些发现的临床转化。成像和光谱核心之间的密切互动， COBRE项目负责人以及数据科学和生物能量学核心将在以下方面带来新的创新： 研究方法，将有利于未来的COBRE调查人员以及更广泛的校园研究 社区将为中心成员、校园和 阿肯色州的生物医学研究人员。成像核心的长期目标是开发和集成 AIMRC成员所需的先进成像方法，并完全独立于COBRE支持 到第三阶段结束时。COBRE第一阶段的短期目标是提供最先进的成像技术 可以被纳入中心项目，开发新的图像分析方法， 项目负责人和数据科学核心，将支持长期目标，并提供支持/教育 中心成员的机会。该提案的具体目标是：1）建立最先进的成像系统， 阿肯色州大学的光谱学核心，满足COBRE项目领导人的需求， 加速他们的独立发展; 2）识别和开发光学显微镜的新应用 和光谱学在校园里，协同生物能量学和数据科学的核心，奠定了 为中心的长期可持续性奠定基础; 3）提供咨询和协调，技术 支持实验设计、样品制备、数据采集的援助和教育机会 和分析，并准备高质量的数字出版物和赠款申请有关的成像。