Imaging & Spectroscopy Core

影像学

• 批准号: 10090746
• 负责人: Narasimhan Rajaram
• 金额: $ 14.27万
• 依托单位: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090746
• 关键词: Aging; Applications Grants; Arkansas; Award; Bioenergetics; Biological Models; Biology; Biomedical Research; Cell physiology; Cells; Cellular Metabolic Process; Centers of Research Excellence; Collaborations; Communities; Consultations; Data Analyses; Data Science; Data Science Core; Disease; Experimental Designs; Fostering; Foundations; Functional disorder; Funding; Future; Goals; Grant; Image; Image Analysis; Imaging Techniques; Imaging technology; Label; Light; Malignant Neoplasms; Medicine; Metabolic; Metabolism; Microscopy; Optics; Phase; Preparation; Publications; Research; Research Methodology; Research Personnel; Resolution; Resources; Role; Sampling; Services; Spectrum Analysis; Structure; Techniques; Technology; Tissues; Training; Translations; United States National Institutes of Health; Universities; Vision; Visualization; clinical translation; data acquisition; imaging approach; innovation; insight; instrument; interdisciplinary collaboration; member; metabolic imaging; novel; programs; spectroscopic imaging; synergism; temporal measurement; wound healing

Project Summary – Imaging and Spectroscopy Core Imaging is a major driver of discovery and translation in biology and medicine. The use of imaging and spectroscopic approaches can often provide insights that may not be available with other techniques that require sample processing. While an Imaging and Spectroscopy Core does not formally exist at the University of Arkansas, the key ingredients necessary to establish one are already present on campus. A range of optical microscopy and spectroscopy instruments are already available for use by other investigators, with several of these set up as service centers. These existing resources will be consolidated and expanded to establish an Imaging and Spectroscopy Core that will meet the research needs of the proposed Arkansas Integrative Metabolic Research Center (AIMRC), have long-term benefits for researchers at the University of Arkansas, and other campuses in the state and in this region of the U.S. The range of technologies available within the Core will allow project leaders to shed new light on cell and tissue metabolism, thus enabling novel discoveries as well as clinical translation of such discoveries. Close interaction between the Imaging and Spectroscopy Core and COBRE project leaders as well as the Data Science and Bioenergetics Cores will lead to new innovations in research methods that will benefit future COBRE investigators as well as the broader campus research community. Hands-on training in imaging technologies will be provided to Center members, the campus and biomedical researchers in Arkansas. The long-term goal of the Imaging Core is to develop and integrate advanced imaging approaches needed by AIMRC members and become fully independent of COBRE support by the end of Phase Ill. The short-term goal for COBRE Phase I is to provide state-of-the-art imaging techniques that can be incorporated into Center projects, develop new image analysis approaches in collaboration with project leaders and the Data Science Core that will support the long-term goal and provide support/educational opportunities to Center members. The specific aims of this proposal are to 1) Establish a state-of-the-art imaging and spectroscopy core at the University Arkansas that meets the needs of the COBRE project leaders and accelerates their progression to independence; 2) Identify and develop new applications of optical microscopy and spectroscopy on campus that synergize with the Bioenergetics and Data Science Cores and lay the foundation for long-term sustainability of the Center; and 3) Provide consultation and coordination, technical assistance and educational opportunities in support of experimental design, sample preparation, data acquisition and analysis, and preparation of high-quality figures for publications and grant applications related to imaging.

项目摘要 - 成像和光谱核心 成像是生物学和医学发现和翻译的主要驱动力。成像的使用和 光谱方法通常可以提供其他需要的技术，这些技术可能无法获得 样本处理。虽然在大学中，成像和光谱核心不正式存在 阿肯色州，建立一种的关键要素已经存在于校园中。一系列光学 显微镜和光谱仪器已经可供其他研究人员使用，其中几个 这些设置为服务中心。这些现有资源将被合并并扩展，以建立 成像和光谱核心将满足拟议的阿肯色州综合性的研究需求 代谢研究中心（AIMRC），为阿肯色大学的研究人员带来长期利益， 该州和美国该地区的其他校园核心中可用的技术范围 将使项目领导者对细胞和组织代谢有了新的启示，从而使新发现也可以 作为此类发现的临床翻译。成像和光谱核之间的紧密相互作用以及 田园项目领导者以及数据科学和生物能力核心将导致新的创新 研究方法将使未来的山毛调查员以及更广泛的校园研究受益 社区。将向中心成员，校园和 阿肯色州的生物医学研究人员。成像核心的长期目标是开发和整合 AIMRC成员需要的高级成像方法，并完全独立于毛线支持 到阶段生病结束时。 可以将其纳入中心项目，与与之合作开发新的图像分析方法 项目负责人和数据科学核心将支持长期目标并提供支持/教育 有机会集中成员。该提案的具体目的是1）建立最先进的成像 以及阿肯色大学的光谱核心 加速他们向独立的发展； 2）识别和开发光学显微镜的新应用 与校园的光谱学与生物能学和数据科学核心协同作用并放置 中心长期可持续性的基础； 3）提供咨询和协调，技术 帮助和教育机会，以支持实验设计，样本准备，数据获取 和分析，并准备与成像有关的出版物和授予应用的高质量数据。