权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The role of negative reinforcement in drug abuse

负强化在药物滥用中的作用

基本信息

批准号：
10356175
负责人：
Matthew L Banks
金额：
$ 19.41万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10356175
关键词：
Address Affect Attenuated Automobile Driving Behavior Behavioral Behavioral Research Brain region Chronic Clinical Cocaine Conflict (Psychology)Data Development Diagnosis Dopamine Drug Exposure Drug abuse Effectiveness Employment Environment Excision Exploratory/Developmental Grant Female Fentanyl Food Food Interactions Foundations Future Goals Impairment Infusion procedures Injections Intravenous Knowledge Lead Literature Methods Negative Reinforcements Negative Reinforcer Neurotransmitters Opiate Addiction Oral Contraceptives Pathway interactions Pharmaceutical Preparations Positive Reinforcer Probability Procedures Process Psychological reinforcement Rattus Research Research Personnel Role Self Administration Shock Signal Transduction Social Interaction Speed Stimulus Substance Use Disorder System Techniques Testing Thinking addiction antagonist attenuation cocaine self-administration cost designer receptors exclusively activated by designer drugs drug misuse drug of abuse drug reinforcement high risk improved innovation insight male neurotransmission non-drug novel novel therapeutics opioid exposure opioid use opioid withdrawal pre-clinical pre-clinical research prevent reinforced behavior reinforcer response stimulant exposure stimulant use disorder transcription factor transcriptome sequencing treatment strategy unintended pregnancy

项目摘要

Project Summary Behavior is governed by contingencies that relate consequent stimuli to responses in the presence of discrete discriminative stimuli. The progression of abused drug misuse to a substance use disorder is diagnosed, in part, by behavior being misallocated towards the abused drug as the positive reinforcer and away from nondrug alternative positive reinforcers (e.g. social interaction, food, employment). Much of this scientific literature has focused on how chronic drug exposure degrades these positive reinforcing stimuli. In contrast, there are few studies that have examined how chronic drug exposure alters behaviors maintained by negative reinforcers (e.g. driving the speed limit to remove the presentation of a speeding ticket). This R21 CEBRA application proposes preclinical research in female and male rats to determine the effects of extended access fentanyl or cocaine self- administration and subsequent termination on behavior maintained by negative reinforcement. Aim #1 will establish a drug-vs-negative reinforcer choice procedure in male and female rats. Aim #2 will compare effects of extended access drug self-administration and extended access negative reinforcement on drug-vs-negative reinforcer chocie.

项目概要行为受偶然事件的控制，这些偶然事件将随后的刺激与存在离散情况下的反应联系起来。歧视性刺激。滥用药物误用发展为药物滥用障碍的部分诊断是，行为被错误地分配给滥用药物作为积极强化物，远离非药物其他积极强化物（例如社交互动、食物、就业）。大部分科学文献都重点关注长期药物暴露如何降低这些积极的强化刺激。相比之下，很少有研究探讨了长期药物暴露如何改变负强化物（例如，驾驶限速以消除超速罚单）。该 R21 CEBRA 应用建议对雌性和雄性大鼠进行临床前研究，以确定长期使用芬太尼或可卡因自我治疗的影响管理和随后终止由负强化维持的行为。目标#1将在雄性和雌性大鼠中建立药物与阴性强化物的选择程序。目标 #2 将比较以下效果扩展获取药物自我管理和扩展获取药物与阴性的负强化强化物选择。