Role of Thermoregulation in MDMA Abuse

描述(由申请人提供)： 本应用旨在通过静脉给药和体内微透析的方法，评估环境温度和甲状腺激素水平对3，4-亚甲基二氧基甲基苯丙胺(MDMA)在非人类灵长类药物滥用模型中增强效果的影响。我们将在22摄氏度和28摄氏度的环境温度下使用同时选择程序来比较自我给药的MDMA的增强和加温效果。此外，将在前两个环境温度下评估MDMA诱导的腹侧纹状体中枢多巴胺的释放。最后，还将评估慢性甲状腺素治疗对MDMA诱导的中枢多巴胺释放、体温升高和自身给药的影响。这项建议旨在阐明MDMA增强作用的潜在机制，并更彻底地了解甲状腺激素和环境温度对MDMA滥用的影响。了解MDMA诱导强化的行为和神经化学机制将有助于提高公众意识，并为滥用MDMA带来的毒性提供更好的药物治疗。

DESCRIPTION (provided by applicant): This application proposes to assess the effects of ambient temperature and thyroid hormone levels on the reinforcing effects of 3,4-methylenedioxymethamphetamine (MDMA) in a non-human primate model of drug abuse through methods of intravenous self-administration and in vivo microdialysis. We will compare the reinforcing and hyperthermic effects of self-administered MDMA using a concurrent choice procedure at ambient temperatures of 22 degrees C and 28 degrees C. Also, central dopamine release induced by MDMA within the ventral striatum will be assesed at the previous two ambient temperatures. Finally, the effects of chronic thyroxine treatment on MDMA-induced central dopamine release, hyperthermia and selfadministration will also be evaluated. This proposal aims to elucidate potential mechanisms involved in the reinforcing effects of MDMA and provide a more thorough understanding of the effects of thyroid hormone and ambient temperature on MDMA abuse. Understanding the behavioral and neurochemical mechanisms involved in MDMA-induced reinforcement will allow for increased public awareness and better pharmacotherapies for the toxicities associated with MDMA abuse.