Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource setting
母亲的逆境、炎症和神经发育:代际过程如何在资源匮乏的环境中延续劣势
基本信息
- 批准号:10356126
- 负责人:
- 金额:$ 48.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-16 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAttention deficit hyperactivity disorderBehavior ControlBehavior assessmentBirthBrainBrazilC-reactive proteinChildClinicDNADNA MethylationDataDevelopmentDiffusionDisadvantagedDiseaseEnrollmentEpigenetic ProcessEtiologyExposure toFamilyFemaleFunctional Magnetic Resonance ImagingFunctional disorderFundingFutureGene ExpressionGene Expression RegulationGenerationsGenesGeneticGenetic RiskGenetic TranscriptionHairHealthcare SystemsHomeHome environmentHydrocortisoneImmuneImmunoassayImpulsive BehaviorImpulsivityInfantInflammationInflammatoryInsula of ReilInterleukin-1 betaInterleukin-6InternationalKnowledgeLifeMagnetic Resonance ImagingMeasuresMediatingMental disordersMeta-AnalysisMethylationModelingMoodsOdds RatioOutcomePathway interactionsPatient Self-ReportPerinatalPeripheralPlacentaPrefrontal CortexPregnancyPregnant WomenPreventionPreventivePrimary Health CareProcessProxyRecording of previous eventsResearchResearch InfrastructureResearch PersonnelResource-limited settingRestRiskRoleSexual abuseSexually Transmitted DiseasesSiteStressSubstance Use DisorderTNF geneTechniquesTestingThird Pregnancy TrimesterTimeToddlerUnited States National Institutes of HealthUniversitiesWorkabuse neglectadverse childhood eventsbasebrain behaviorchildhood adversitycognitive controldepressive symptomsdesignfetalgenome wide association studyhigh riskhigh risk sexual behaviorindexinginflammatory markerintergenerationalmalemood symptomneural circuitneurodevelopmentneurodevelopmental effectnext generationoffspringparental monitoringperceived stresspolygenic risk scorepoor communitiespostnatalpre-clinicalpre-clinical researchprenatalprenatal stressresponsesextranscriptome sequencingtransmission process
项目摘要
PROJECT SUMMARY
Adverse childhood experiences (ACEs) - which includes physical/sexual abuse, neglect or parental
mental illness - confer risk for psychiatric dysfunction not only to those directly exposed, but also to
the next generation. However, mechanisms underlying these ACE-related intergenerational
effects are unclear, significantly limiting a unique prevention opportunity. Our study aims to examine
mechanisms by which maternal ACEs influence offspring neurodevelopment, with special focus on
prenatal inflammation. Toward this end, we will enroll, in the Brazilian Universal Health Care system
(SUS), pregnant women with (n=290) and without (n=290) a history of substantial ACEs and follow
their offspring over the first two years of life focused on the neurodevelopment of cognitive control, a
cornerstone in the future development of impulsive behaviors. First, we will start by testing
associations between maternal ACEs and offspring brain-behavior development using infant MRI and
behavioral assessments of cognitive control. Second, we will examine mechanisms underlying these
associations, focusing on the role of prenatal inflammation and the placenta using techniques to
examine DNA epigenetics and RNA sequencing, while also taking into account genetic influences. As
suggested by preclinical research, we hypothesize differential effects of prenatal inflammation in male
vs. female pregnancies. In addition, we will explore modifiable post-natal factors and their influence
on offspring neurodevelopment, monitoring parental depressive/mood symptoms and conducting two
in-home assessments of the family. Revealing mechanisms of intergenerational transmission of
adversity, our study will set the stage for high-impact preventive research. We will establish research
infrastructure within a São Paulo
primary care clinic network in a high-risk, low-resource community
where preventive effects can have their most substantial impact. This R01 proposal is designed to be
highly responsive to the NIH-FAPESP Funding Initiative (NOT-TW-16-001), which aims to support
collaborative international research between investigators in the US and a stellar research group in
the State of São Paulo, Brazil.
项目概要
不良童年经历(ACE)——包括身体/性虐待、忽视或父母的虐待
精神疾病——不仅给直接接触者带来精神功能障碍的风险,还给
下一代。然而,这些 ACE 相关代际间的潜在机制
效果尚不清楚,严重限制了独特的预防机会。我们的研究旨在检验
母体 ACE 影响后代神经发育的机制,特别关注
产前炎症。为此,我们将加入巴西全民医疗保健系统
(SUS),有 (n=290) 和没有 (n=290) 大量 ACE 病史的孕妇,并遵循
他们的后代在生命的头两年专注于认知控制的神经发育,
未来冲动行为发展的基石。首先,我们将从测试开始
使用婴儿 MRI 和
认知控制的行为评估。其次,我们将研究这些背后的机制
协会,重点关注产前炎症和胎盘的作用,利用技术
检查 DNA 表观遗传学和 RNA 测序,同时也考虑遗传影响。作为
根据临床前研究的建议,我们假设产前炎症对男性的不同影响
与女性怀孕相比。此外,我们还将探讨可改变的产后因素及其影响
对后代神经发育的影响,监测父母的抑郁/情绪症状并进行两个
家庭内部评估。揭示代际传播机制
逆境中,我们的研究将为高影响力的预防性研究奠定基础。我们将建立研究
圣保罗的基础设施
高风险、资源匮乏社区的初级保健诊所网络
预防效果可以产生最实质性的影响。该 R01 提案旨在
对 NIH-FAPESP 资助计划 (NOT-TW-16-001) 高度响应,该计划旨在支持
美国研究人员与美国著名研究小组之间的国际合作研究
巴西圣保罗州。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Cristiane S. Duarte其他文献
3.21 <em>DSM-5</em> ANXIETY DISORDERS AMONG YOUNG ADULTS IN THE UNITED STATES
- DOI:
10.1016/j.jaac.2016.09.153 - 发表时间:
2016-10-01 - 期刊:
- 影响因子:
- 作者:
Cristiane S. Duarte;Chiaying Wei;Shuai Wang;Anne M. Albano;Moira A. Rynn;John T. Walkup;Mark Olfson - 通讯作者:
Mark Olfson
6.162 CHILD PSYCHOPATHOLOGY AFTER TREATMENT OF MATERNAL DEPRESSION IN PRIMARY CARE IN BRAZIL
- DOI:
10.1016/j.jaac.2016.09.477 - 发表时间:
2016-10-01 - 期刊:
- 影响因子:
- 作者:
Elis Viviane Hoffmann;Cristiane S. Duarte;Andrea F. Mello;Camila T. Matsuzaka;Victor Fossaluza;Marcelo Feijó de Mello - 通讯作者:
Marcelo Feijó de Mello
3.5 Teen Motherhood in Context: Examining the Relationship Between Teen Motherhood and Children's Antisocial Behaviors in Puerto Rican Youth Living in Different Social Contexts
- DOI:
10.1016/j.jaac.2017.09.153 - 发表时间:
2017-10-01 - 期刊:
- 影响因子:
- 作者:
Maria A. Ramos-Olazagasti;Glorisa J. Canino;Hector R. Bird;Cristiane S. Duarte - 通讯作者:
Cristiane S. Duarte
1.20 Maternal Adverse Childhood Experiences and Offspring Externalizing Problems: Are Maternal Familism and Social Support Resilience Factors Among Puerto Rican Families?
- DOI:
10.1016/j.jaac.2023.09.027 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
Tre D. Gissandaner;Renald Dambreville;Cristiane S. Duarte - 通讯作者:
Cristiane S. Duarte
4.59 The Impact of Adverse Childhood Experience (ACE) Type on the Relationship Between ACEs and Dimensions of Substance Use Risk in Puerto Rican Children Aged 10-15
- DOI:
10.1016/j.jaac.2023.09.303 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
Tamara J. Sussman;Lillian Polanco-Roman;Jazmin Reyes-Portillo;William A. Campo;Mia R. Lancellotti;Camila P. Goldner Pérez;Cristiane S. Duarte - 通讯作者:
Cristiane S. Duarte
Cristiane S. Duarte的其他文献
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{{ truncateString('Cristiane S. Duarte', 18)}}的其他基金
Mental health and Bolsa Familia: A mechanistically focused clinical trial of a cash transfer intervention on child brain, behavior, and mental health
心理健康和 Bolsa Familia:现金转移干预对儿童大脑、行为和心理健康的机械重点临床试验
- 批准号:
10573268 - 财政年份:2022
- 资助金额:
$ 48.03万 - 项目类别:
Mental health and Bolsa Familia: A mechanistically focused clinical trial of a cash transfer intervention on child brain, behavior, and mental health
心理健康和 Bolsa Familia:现金转移干预对儿童大脑、行为和心理健康的机械重点临床试验
- 批准号:
10375234 - 财政年份:2022
- 资助金额:
$ 48.03万 - 项目类别:
Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource setting
母亲的逆境、炎症和神经发育:代际过程如何在资源匮乏的环境中延续劣势
- 批准号:
10369780 - 财政年份:2020
- 资助金额:
$ 48.03万 - 项目类别:
Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource setting
母亲的逆境、炎症和神经发育:代际过程如何在资源匮乏的环境中延续劣势
- 批准号:
10550025 - 财政年份:2020
- 资助金额:
$ 48.03万 - 项目类别:
Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource setting
母亲的逆境、炎症和神经发育:代际过程如何在资源匮乏的环境中延续劣势
- 批准号:
10563215 - 财政年份:2020
- 资助金额:
$ 48.03万 - 项目类别:
Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource setting
母亲的逆境、炎症和神经发育:代际过程如何在资源匮乏的环境中延续劣势
- 批准号:
9917445 - 财政年份:2020
- 资助金额:
$ 48.03万 - 项目类别:
Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource setting
母亲的逆境、炎症和神经发育:代际过程如何在资源匮乏的环境中延续劣势
- 批准号:
10772200 - 财政年份:2020
- 资助金额:
$ 48.03万 - 项目类别:
Substance Use/Abuse & HIV/STI Risk Behaviors in Puerto Rican Youth Growing Up
药物使用/滥用
- 批准号:
9271319 - 财政年份:2012
- 资助金额:
$ 48.03万 - 项目类别:
Substance Use/Abuse & HIV/STI Risk Behaviors in Puerto Rican Youth Growing Up
药物使用/滥用
- 批准号:
8450773 - 财政年份:2012
- 资助金额:
$ 48.03万 - 项目类别:
Substance Use/Abuse & HIV/STI Risk Behaviors in Puerto Rican Youth Growing Up
药物使用/滥用
- 批准号:
9059932 - 财政年份:2012
- 资助金额:
$ 48.03万 - 项目类别:
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