The University of Iowa Clinical and Translational Science Award

爱荷华大学临床和转化科学奖

• 批准号: 10356826
• 负责人: Marlan R Hansen
• 金额: $ 370.94万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10356826
• 关键词: Academic Medical Centers; Address; Affect; Age; Area; Automobile Driving; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Collection; Communities; Community Health; Community Practice; Computerized Medical Record; Data; Data Collection; Development; Discipline; E-learning; Family Physicians; Genetic; Goals; Health; Health Personnel; Health system; Healthcare; Home; Hospitals; Human; Human Subject Research; Infrastructure; Institutes; Institution; Intervention; Iowa; Lead; Learning; Life; Link; Longevity; Measurable; Medical Care Team; Methods; Mission; Modeling; Participant; Patient Participation; Patients; Performance; Pharmacists; Population; Process; Research; Research Personnel; Rural; Rural Community; Rural Population; School Nursing; Science; Scientist; System; Technology; Testing; Time; Training; Translational Research; Translations; Universities; base; catalyst; clinical practice; college; community engaged research; community engagement; community organizations; community partnership; data warehouse; demographics; efficacy testing; evidence base; geographic barrier; health care delivery; improved; informatics infrastructure; innovation; innovative technologies; member; novel; novel strategies; novel therapeutics; patient population; precision medicine; programs; rural patients; rurality; social; tertiary care; tool; translational scientist; workforce needs

The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) was established by the Board of Regents to realize three objectives – first, to lead the development of translational science at the UI; second, to advance translational science as a distinct academic discipline; and third, to disseminate capacities in translational science across the State of Iowa. This mandate enabled us to tackle large problems affecting translational science that required institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well trained clinical and translational researchers. Iowa is a rural state, which brings special health care needs and challenges. We have used these rural considerations as a catalyst for driving our approach to clinical and translational research pushing our teams to develop strategies to engage rural populations of all ages and backgrounds and to create new approaches that overcome the geographic barriers in a rural state. We are capitalizing on our established community practice networks of family physicians, clinics, school nurses and pharmacists. We utilize e Health/ e Learning platforms in novel ways and will test the efficacy of these new methods of engagement. As we move research “Beyond Our Borders,” we have created methods to capture real-time, real-life data from the home and to correlate this environmentally specific, comprehensive data to human performance. The ICTS is engaging with other CTSA hubs and national CTR systems to empirically test different approaches and to develop the evidence base of proven strategies for accelerating translation that can be more broadly disseminated. Though distance and rurality drive our approaches, the strategies that we develop are simply new and potentially better ways to generate broad representation and improved participation by patients, healthcare teams and academicians. Through our local, state and national partnerships, UI and the ICTS are poised to move clinical and translational discovery rapidly into healthcare practice in a variety of clinical settings.

爱荷华州大学（UI）的临床和转化科学研究所（ICTS）由 董事会实现三个目标--第一，引领UI翻译科学的发展; 第二，促进翻译科学作为一个独特的学科;第三，传播能力 在整个爱荷华州的转化科学中。这一授权使我们能够处理影响到 转化科学需要体制性的解决方案，如改变人类的监管过程， 主题研究，开发信息基础设施，整合电子病历和其他 卫生保健数据，与社区组织建立双向关系， 训练有素的临床和转化研究人员的管道。 爱荷华州是一个农村州，带来了特殊的医疗保健需求和挑战。我们利用这些农村 作为推动我们的临床和转化研究方法的催化剂，推动我们的团队 制定战略，使所有年龄和背景的农村人口参与，并创造新的办法， 克服农村地区的地理障碍。我们正在利用我们建立的社区惯例 家庭医生、诊所、学校护士和药剂师网络。我们利用e健康/e学习 我们将以新的方式建立新的平台，并将测试这些新的参与方法的有效性。当我们把研究 “超越我们的边界”，我们已经创造了从家里捕捉实时，真实生活数据的方法， 将这些特定于环境的综合数据与人的表现联系起来。信通技术正在与 其他CTSA中心和国家CTR系统，以实证方式测试不同的方法， 可以更广泛传播的经证实的加速翻译战略的证据基础。虽然 距离和乡村驱动我们的方法，我们开发的策略只是新的和潜在的更好 如何产生广泛的代表性和改善患者，医疗团队和 院士们通过我们的地方，州和国家的合作伙伴关系，UI和ICTS准备将临床 并将发现转化为各种临床环境中的医疗实践。

项目成果

Word Reading in Boys With Isolated Oral Clefts: Comparison to Unaffected Average and Dyslexic Readers Using the Dual-Route Model.

患有孤立性口腔裂的男孩的单词阅读：使用双路线模型与未受影响的普通读者和诵读困难读者进行比较。

• DOI: 10.1177/1055665619867015
• 发表时间: 2020
• 期刊: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
• 作者: Kuhlmann,EmilyHope;Conrad,AmyLynn
• 通讯作者: Conrad,AmyLynn

Response by Holwerda et al to Letter Regarding Article "Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults".

Holwerda 等人对有关文章“肌肉交感神经活动升高导致年轻和中年/老年人中央动脉僵硬”的信件的回应。

• DOI: 10.1161/hypertensionaha.119.13299
• 发表时间: 2019
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Holwerda,SethW;Fadel,PaulJ;Abboud,FrancoisM;Pierce,GaryL
• 通讯作者: Pierce,GaryL

Sequential intravesical gemcitabine and docetaxel for treatment-naïve and previously treated intermediate-risk nonmuscle invasive bladder cancer.

连续膀胱内注射吉西他滨和多西他赛用于治疗初治和既往治疗过的中危非肌层浸润性膀胱癌。

• DOI: 10.1016/j.urolonc.2023.06.017
• 发表时间: 2023
• 期刊: Urologic oncology
• 作者: McElree,IanM;Orzel,Joanna;Stubbee,Reid;Steinberg,RyanL;Mott,SarahL;O'Donnell,MichaelA;Packiam,VigneshT
• 通讯作者: Packiam,VigneshT

Tackling the opioid epidemic: Reducing opioid prescribing while maintaining patient satisfaction with pain management after outpatient surgery.

解决阿片类药物流行：减少阿片类药物处方，同时在门诊手术后保持患者对疼痛管理的满意度。

• DOI: 10.1016/j.amjsurg.2020.04.006
• 发表时间: 2020-10
• 期刊: American journal of surgery
• 影响因子: 3
• 作者: Allan LD;Coyne C;Byrnes CM;Galet C;Skeete DA
• 通讯作者: Skeete DA

Diagnosed and Undiagnosed COVID-19 in US Emergency Department Health Care Personnel: A Cross-sectional Analysis.

在美国急诊室卫生保健人员中被诊断和未诊断的Covid-19：横断面分析。

• DOI: 10.1016/j.annemergmed.2020.12.007
• 发表时间: 2021-07
• 期刊: Annals of emergency medicine
• 影响因子: 6.2
• 作者: Mohr NM;Harland KK;Krishnadasan A;Eyck PT;Mower WR;Willey J;Chisolm-Straker M;Lim SC;McDonald LC;Kutty PK;Hesse E;Santibanez S;Talan DA;Project COVERED Emergency Department Network
• 通讯作者: Project COVERED Emergency Department Network