University of Iowa Institute for Clinical and Translational Science

摘要 爱荷华州（UI）的临床和转化科学研究所（ICTS）有三个目标：（1） 促进一个创新的、综合的、地理分布的框架， 转化研究，2）创造新的方法和工具，促进研究参与，数据收集， 以及将诊所与家庭联系起来的干预措施; 3）发展促进 创新的科学。ICTS解决了影响转化科学的重大问题， 需要制度性的解决方案，例如改变人类受试者研究的监管程序， 开发用于整合电子医疗记录和其他卫生保健数据的信息学基础设施， 建立与社区组织的双向关系，并恢复良好的管道， 训练有素的临床和转化研究人员。我们的首要目标是加快研究整合到 全国各地的临床合作伙伴关系，并通过团队科学，使我们的基础，转化和临床 研究人员一起提升科学发现的速度和广度，以影响医疗保健， 国家和超越。 爱荷华州是一个农村州，带来了特殊的医疗保健需求和挑战。我们利用这些农村 作为推动我们的临床和转化研究方法的催化剂，推动我们的团队 制定战略，使所有年龄和背景的农村人口参与，并创造新的办法， 克服农村地区的地理障碍。我们正在利用我们建立的社区惯例 家庭医生、诊所、学校护士和药剂师网络。我们利用移动的平台， 这些方法将检验这些接触方法的有效性。当我们将研究转移到“影响 利用创新、网络和参与的地区- IMAG-INE”我们创造了各种方法， 捕捉实时的，现实生活中的数据，从家里，并关联这种环境的具体，全面 人类健康研究和成果的数据。ICTS正在与CTSA的其他中心和国家 临床和转化研究系统，以经验性地测试不同的方法，并开发证据 经过验证的加速翻译战略的基础，可以更广泛地传播。虽然距离 和乡村驱动我们的方法，我们开发的策略只是新的和潜在的更好的方法， 产生广泛的代表性，提高患者、医疗团队和学者的参与度。 通过我们的地方，州和国家的合作，UI和ICTS准备将临床和 在各种临床环境中，将转化发现快速转化为医疗实践。

ABSTRACT The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) has three aims – (1) to promote an innovative, integrated, geographically distributed framework for conducting clinical and translational research, 2) to create new methods and tools that promote research participation, data collection, and interventions that link the clinic to the home and 3) to develop the diverse workforce needed to catalyze innovative science throughout populations. ICTS tackles large problems affecting translational science that require institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well- trained clinical and translational researchers. Our overarching goal is to accelerate integration of research into clinical partnerships around the state and, through team science, bringing our basic, translational and clinical research workforce together to escalate the pace and breadth of scientific discovery to impact healthcare for the state and beyond. Iowa is a rural state, which brings special health care needs and challenges. We have used these rural considerations as a catalyst for driving our approach to clinical and translational research pushing our teams to develop strategies to engage rural populations of all ages and backgrounds and to create new approaches that overcome the geographic barriers in a rural state. We are capitalizing on our established community practice networks of family physicians, clinics, school nurses and pharmacists. We utilize mobile platforms in novel ways and will test the efficacy of these methods of engagement. As we move research to “IMpact Across Geographies using Innovation, Networks and Engagement- IMAG-INE” we have created methods to capture real-time, real-life data from the home and to correlate this environmentally specific, comprehensive data to human health research and outcomes. The ICTS is engaging with other CTSA hubs and national clinical and translational research systems to empirically test different approaches and to develop the evidence base of proven strategies for accelerating translation that can be more broadly disseminated. Though distance and rurality drive our approaches, the strategies that we develop are simply new and potentially better ways to generate broad representation and improved participation by patients, healthcare teams and academicians. Through our local, state and national collaborations, UI and the ICTS are poised to move clinical and translational discovery rapidly into healthcare practice in a variety of clinical settings.