Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma

调整和测试一种新颖的自我慈悲干预措施以减少肺癌耻辱感

• 批准号: 10361424
• 负责人: Timothy J Williamson
• 金额: $ 12.47万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-08-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361424
• 关键词: Address; Adult; Anxiety; Area; Attenuated; Basic Behavioral Science; Behavioral; Behavioral Research; Behavioral Sciences; Breathing; Cancer Control; Cancer Intervention; Cancer Patient; Centers for Disease Control and Prevention (U.S.); Clinical; Cognition; Compassion; Competence; Data; Development; Diagnosis; Disease; Disease Progression; Distress; Feeling; Focus Groups; Future; Germ; Goals; Health; Health Sciences; Individual; Intervention; Interview; Investigation; Link; Malignant Neoplasms; Malignant neoplasm of lung; Maps; Measures; Meditation; Memorial Sloan-Kettering Cancer Center; Mental Health; Mentors; Mentorship; Methods; Oncology; Outcome; Participant; Patients; Perception; Persons; Phase; Population; Positioning Attribute; Process; Protocols documentation; Psychosocial Influences; Public Health; Quality of life; Randomized Clinical Trials; Reaction; Regrets; Reporting; Research; Research Personnel; Sampling; Shame; Site; Smoking; Source; Stressful Event; Structure; Testing; Time; Training; Translating; Translations; United States National Institutes of Health; base; behavioral/social science; cancer care; career development; depressive symptoms; design; efficacy testing; experience; improved; internalized stigma; lung cancer screening; mindfulness; novel; patient population; physical conditioning; pilot test; post intervention; preference; psychoeducation; psychologic; psychosocial; responders and non-responders; screening; secondary outcome; social influence; social science research; social stigma; standard of care; statistics; synergism; telehealth; therapy development

Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030. Nearly all (95%) patients diagnosed with lung cancer report experiencing stigma (i.e., the perception and internalization of negative appraisal from others attributed to one’s lung cancer), which is perhaps the most prominent psychosocial issue in this population and contributes to poor psychological and physical health outcomes. A critical gap in the field of cancer control science is the lack of empirically supported patient-focused interventions that target the reduction of lung cancer stigma for this growing patient population. The goals of this K99/R00 are to adapt the existing Mindful Self-Compassion (MSC) psychosocial intervention to address anticipated delivery challenges and target the reduction of lung cancer stigma as well as to seek preliminary evidence for the efficacy of the adapted MSC intervention in reducing lung cancer stigma. The K99 study will involve a two-phase process of 1) conducting stakeholder focus groups to guide the iterative adaptation of MSC intervention activities and materials and 2) conducting in-depth interviews with lung cancer patients to explore patients’ reactions to intervention content and preferences for format and delivery. The R00 study will involve a two-phase process of 1) conducting a pilot RCT (n=60) to test preliminary efficacy of the adapted MSC intervention on primary (lung cancer stigma) and secondary outcomes (depressive symptoms, quality of life) and 2) conducting interviews with purposively sampled high responders (n=10) and non-responders (n=10) from the MSC condition (assessed post-intervention) to examine participants’ reactions to study participation. The overall objective of this K99/R00 is to provide Dr. Williamson with additional training and mentorship to become an independent cancer control investigator translating findings from basic behavioral scientific research into the development of tailored psychosocial interventions for cancer patients. Training aims include: 1) Psychosocial intervention development and adaptation in cancer; 2) advanced qualitative and mixed-methods design and analysis; 3) translational psychological research (synergy between basic and applied health science); 4) delivery of mindfulness- and compassion-based interventions in cancer care; and 5) professional development. Dr. Williamson is mentored by Dr. Jamie Ostroff at Memorial Sloan Kettering Cancer Center along with expert support from co-mentors (Drs. Lisa Carter-Harris and Jun Mao) and other significant contributors (Dr. Christopher Germer, Ms. Kathleen Lynch), who are all committed to Dr. Williamson’s career development. The proposed training plan will facilitate Dr. Williamson’s transition to independence as a cancer control investigator conducting a programmatic line of research that 1) characterizes disease-specific challenges of understudied cancer groups and 2) translates findings from basic behavioral research into tailored psychosocial interventions that address such challenges and ultimately enhance quality of life.

项目总结