Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma

调整和测试一种新颖的自我慈悲干预措施以减少肺癌耻辱感

• 批准号: 10867877
• 负责人: Timothy J Williamson
• 金额: $ 2.84万
• 依托单位: LOYOLA MARYMOUNT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10867877
• 关键词: Address; Adult; Anxiety; Area; Attenuated; Basic Behavioral Science; Behavioral; Behavioral Research; Behavioral Sciences; Breathing; Cancer Control; Cancer Intervention; Cancer Patient; Clinical; Cognition; Compassion; Competence; Data; Development; Diagnosis; Disease; Disease Progression; Distress; Feeling; Focus Groups; Future; Goals; Health; Health Sciences; Individual; Intervention; Interview; Investigation; Link; Malignant Neoplasms; Malignant neoplasm of lung; Maps; Measures; Meditation; Memorial Sloan-Kettering Cancer Center; Mental Health; Mentors; Mentorship; Methods; Oncology; Outcome; Participant; Patients; Perception; Persons; Phase; Population; Positioning Attribute; Process; Protocols documentation; Psychosocial Influences; Public Health; Quality of life; Reaction; Regrets; Reporting; Research; Research Personnel; Sampling; Shame; Site; Smoking; Source; Stressful Event; Structure; Testing; Training; Translating; Translations; United States National Institutes of Health; behavioral and social science; cancer care; career development; depressive symptoms; design; efficacy testing; experience; improved; internalized stigma; lung cancer screening; mindfulness; novel; patient population; physical conditioning; pilot test; post intervention; preference; psychoeducation; psychoeducational; psychologic; psychosocial; randomized, clinical trials; responders and non-responders; screening; secondary outcome; social influence; social science research; social stigma; standard of care; statistics; synergism; telehealth; theories; therapy development; understudied cancer

Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030. Nearly all (95%) patients diagnosed with lung cancer report experiencing stigma (i.e., the perception and internalization of negative appraisal from others attributed to one’s lung cancer), which is perhaps the most prominent psychosocial issue in this population and contributes to poor psychological and physical health outcomes. A critical gap in the field of cancer control science is the lack of empirically supported patient-focused interventions that target the reduction of lung cancer stigma for this growing patient population. The goals of this K99/R00 are to adapt the existing Mindful Self-Compassion (MSC) psychosocial intervention to address anticipated delivery challenges and target the reduction of lung cancer stigma as well as to seek preliminary evidence for the efficacy of the adapted MSC intervention in reducing lung cancer stigma. The K99 study will involve a two-phase process of 1) conducting stakeholder focus groups to guide the iterative adaptation of MSC intervention activities and materials and 2) conducting in-depth interviews with lung cancer patients to explore patients’ reactions to intervention content and preferences for format and delivery. The R00 study will involve a two-phase process of 1) conducting a pilot RCT (n=60) to test preliminary efficacy of the adapted MSC intervention on primary (lung cancer stigma) and secondary outcomes (depressive symptoms, quality of life) and 2) conducting interviews with purposively sampled high responders (n=10) and non-responders (n=10) from the MSC condition (assessed post-intervention) to examine participants’ reactions to study participation. The overall objective of this K99/R00 is to provide Dr. Williamson with additional training and mentorship to become an independent cancer control investigator translating findings from basic behavioral scientific research into the development of tailored psychosocial interventions for cancer patients. Training aims include: 1) Psychosocial intervention development and adaptation in cancer; 2) advanced qualitative and mixed-methods design and analysis; 3) translational psychological research (synergy between basic and applied health science); 4) delivery of mindfulness- and compassion-based interventions in cancer care; and 5) professional development. Dr. Williamson is mentored by Dr. Jamie Ostroff at Memorial Sloan Kettering Cancer Center along with expert support from co-mentors (Drs. Lisa Carter-Harris and Jun Mao) and other significant contributors (Dr. Christopher Germer, Ms. Kathleen Lynch), who are all committed to Dr. Williamson’s career development. The proposed training plan will facilitate Dr. Williamson’s transition to independence as a cancer control investigator conducting a programmatic line of research that 1) characterizes disease-specific challenges of understudied cancer groups and 2) translates findings from basic behavioral research into tailored psychosocial interventions that address such challenges and ultimately enhance quality of life.

项目摘要 鉴于筛查和治疗的进步，美国肺癌患者的数量是 预计到2030年将增加25%（从571，340增加到724，610）。几乎所有（95%）诊断为 肺癌报告经历耻辱（即，负面评价的感知和内化 其他人归因于肺癌），这可能是这一时期最突出的心理社会问题。 这是一个严重的社会问题，也是导致不良心理和身体健康结果的原因。一个关键的空白领域， 癌症控制科学缺乏经验支持的以患者为中心的干预措施， 减少对这一不断增长的患者群体的肺癌污名化。K99/R 00的目标是适应 现有的正念自我补偿（MSC）心理社会干预，以应对预期的交付挑战 并以减少肺癌的耻辱感为目标，并寻求初步证据证明 适应MSC干预减少肺癌的耻辱。K99研究将分两个阶段进行， 1)开展利益相关者焦点小组活动，以指导MSC干预活动的迭代调整， 材料和2）对肺癌患者进行深入访谈，以探讨患者对 干预内容以及格式和交付的偏好。R 00研究将分两个阶段进行 1）进行试点RCT（n=60）以测试适应性MSC干预对原发性骨髓瘤的初步功效， (lung癌症污名）和次要结果（抑郁症状，生活质量）和2）进行 对MSC中有目的抽样的高应答者（n=10）和无应答者（n=10）进行访谈 条件（干预后评估），以检查参与者对研究参与的反应。整体 本K99/R 00的目标是为威廉姆森博士提供额外的培训和指导，使其成为 独立的癌症控制调查员将基础行为科学研究的发现转化为 为癌症患者制定量身定制的心理社会干预措施。培训目标包括：1）心理社会 癌症的干预开发和适应; 2）先进的定性和混合方法设计， 转化心理学研究（基础与应用健康科学之间的协同作用）; 在癌症护理中提供基于正念和同情的干预措施;以及5）专业 发展威廉姆森博士在纪念斯隆凯特琳癌症中心接受杰米奥斯特罗夫博士的指导 沿着来自共同导师（丽莎卡特-哈里斯博士和毛军博士）和其他重要专家的支持， 贡献者（克里斯托弗·格默博士，凯瑟琳·林奇女士），他们都致力于威廉姆森博士的职业生涯 发展拟议的培训计划将有助于威廉姆森博士过渡到独立， 癌症控制研究者进行研究的纲领性路线，1）表征疾病特异性 研究不足的癌症群体的挑战和2）将基础行为研究的结果转化为 有针对性的心理社会干预措施，以应对这些挑战，并最终提高生活质量。