Research Training at the Confluence of Infectious and Non-Communicable Diseases in India

印度传染病和非传染性疾病交汇处的研究培训

• 批准号: 10361555
• 负责人: JEFFERY S COX
• 金额: $ 18.69万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361555
• 关键词: Acute respiratory infection; Address; Age; Applications Grants; California; Caring; Chronic; Cities; Collaborations; Communicable Diseases; Country; Data Analyses; Development; Diabetes Mellitus; Educational process of instructing; Educational workshop; Emerging Communicable Diseases; Epidemiology; Faculty; Frequencies; Goals; Human Resources; India; Institution; Laboratories; Medical; Mentors; Mentorship; Modernization; Molecular; Molecular Epidemiology; Population; Prevalence; Public Health; Research; Research Institute; Research Training; San Francisco; Scientist; Site; System; Technology; Training; Training Programs; Universities; Work; bacterial resistance; data management; epidemiology study; member; programs; public health research; respiratory; rural area; surveillance data

The goal of this 5-year Global Infectious Diseases (GID) training grant proposal is to establish a research and training program in India focused on the study of the interaction of infectious diseases (IDs) with non-communicable diseases (NCD). NCDs, such as diabetes and chronic respiratory illnesses, are rapidly increasing in prevalence in India as the middle class expands, the population ages, and modern medical care and technology become more accessible. However, IDs, including TB and acute respiratory infections, remain a substantial burden. India is also an important center for the development and spread of bacterial resistance. The high frequency of IDs combined with the substantial and growing burden of NCDs drives a need for Indian scientists with an expertise in NCD-associated infectious diseases (NCDAID). This program will be established at JSS University (JSSU), a medical teaching center in Mysore, Karnataka, India, that serves Mysore city and surrounding rural regions of South India. Collaborators include the Public Health Research Institute, India (PHRII), also located in Mysore, and the University of California at Berkeley (UCB) and San Francisco (UCSF). Key personnel at these institutions have ongoing projects and collaborations. This training program will expand the number of faculty and range of projects involved in these collaborations to include projects along two specific tracks: (1) field epidemiology and (2) molecular epidemiology. Projects will initially focus on infectious diseases associated with diabetes mellitus and chronic respiratory illnesses. Masters, medical, or doctoral candidate trainees in the field epidemiology track (1-2 per year) will train in the US for 6 months before returning to India to conduct their field work with support from PHRII and their JSSU mentors. Doctoral trainees will return to the US for up to 12 months to conduct advanced data analyses with their US mentors. We also propose to create a data surveillance and analysis/management system at JSSU that can serve as a long-term training site to study NCDAID in South India. The molecular epidemiology track will include the training of a junior faculty member in the US for 2 years, who will then return to establish a molecular epidemiology laboratory at JSSU. Then, each year a doctoral candidate will be trained for 12 months in the US who will then return to help establish and complete their research in the new JSSU facility. In-country workshops will be held annually for trainees and faculty in molecular epidemiology, data management and analysis, and mentorship. We thus plan to establish a long- term molecular and field epidemiological research capacity at JSSU that can address this emerging ID public health problem resulting from the increasing prevalence of NCDs in India.

这项为期5年的全球传染病（GID）培训赠款提案的目标是在印度建立一个研究和培训计划，重点研究传染病（ID）与非传染性疾病（NCD）的相互作用。随着印度中产阶级的扩大、人口老龄化以及现代医疗保健和技术的普及，糖尿病和慢性呼吸道疾病等非传染性疾病的流行率正在迅速上升。然而，包括结核病和急性呼吸道感染在内的传染病仍然是一个巨大的负担。印度也是细菌耐药性发展和传播的重要中心。高频率的传染病加上非传染性疾病的巨大和日益增长的负担，推动了对印度科学家在非传染性疾病相关传染病（NCDAID）方面的专业知识的需求。该计划将在印度卡纳塔克邦迈索尔的医学教学中心JSS大学（JSSU）建立，为迈索尔市和印度南部周边农村地区提供服务。合作者包括同样位于迈索尔的印度公共卫生研究所、加州大学伯克利分校和旧金山弗朗西斯科分校。这些机构的关键人员正在开展项目和合作。该培训计划将扩大参与这些合作的教师数量和项目范围，以包括沿着两个具体轨道的项目：（1）现场流行病学和（2）分子流行病学。项目最初将侧重于与糖尿病和慢性呼吸道疾病有关的传染病。现场流行病学轨道的硕士，医学或博士候选人学员（每年1-2名）将在美国培训6个月，然后返回印度，在PHRII及其JSSU导师的支持下进行实地工作。博士生将返回美国长达12个月，与美国导师一起进行高级数据分析。我们还建议在JSSU建立一个数据监测和分析/管理系统，可以作为一个长期的培训网站，在印度南部学习NCDAID。分子流行病学轨道将包括在美国的初级教员的培训2年，谁将返回建立在JSSU分子流行病学实验室。然后，每年一名博士生将在美国接受12个月的培训，然后返回新的JSSU设施帮助建立和完成他们的研究。每年将为受训人员和教员举办分子流行病学、数据管理和分析以及指导方面的国内讲习班。因此，我们计划在JSSU建立长期的分子和现场流行病学研究能力，以解决印度非传染性疾病日益流行造成的这一新出现的ID公共卫生问题。

项目成果

The Use of High-Flow Nasal Cannula and Non-Invasive Mechanical Ventilation in the Management of COVID-19 Patients: A Prospective Study.

• DOI: 10.3390/v15091879
• 发表时间: 2023-09-05
• 期刊: Viruses
• 作者: Arunachala S;Parthasarathi A;Basavaraj CK;Malamardi S;Chandran S;Venkataraman H;Ullah MK;Ganguly K;Upadhyay S;Mahesh PA
• 通讯作者: Mahesh PA

Armed conflict, HIV, and syndemic risk markers of mental distress, alcohol misuse, and intimate partner violence among couples in Uganda.

• DOI: 10.1002/jts.22740
• 发表时间: 2021-10
• 期刊: Journal of traumatic stress
• 影响因子: 3.3
• 作者: Mootz JJ;Basaraba CN;Corbeil T;Johnson K;Kubanga KP;Wainberg ML;Khoshnood K
• 通讯作者: Khoshnood K

Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India.

• DOI: 10.3390/antibiotics11111577
• 发表时间: 2022-11-09
• 期刊: Antibiotics (Basel, Switzerland)

Circulatory Serum Krebs von Den Lungen-6 and Surfactant Protein-D Concentrations Predict Interstitial Lung Disease Progression and Mortality.

• DOI: 10.3390/cells12091281
• 发表时间: 2023-04-28
• 期刊: Cells
• 影响因子: 6

Transactional sex work and HIV among women in conflict-affected Northeastern Uganda: a population-based study.

• DOI: 10.1186/s13031-022-00441-5
• 发表时间: 2022-02-25
• 期刊: Conflict and health
• 影响因子: 3.6
• 作者: Mootz JJ;Odejimi OA;Bhattacharya A;Kann B;Ettelbrick J;Mello M;Wainberg ML;Khoshnood K
• 通讯作者: Khoshnood K