UCSF-UCB Tuberculosis Research Advancement Center (TRAC)

项目摘要 拟议的加州大学旧金山弗朗西斯科-加州大学伯克利分校结核病研究促进中心的总体目标 （UCSF-UCB TRAC）是为了加快发现的步伐，提高我们对结核病（TB）的理解 并直接导致诊断、预防和治疗结核病的新工具。解决复杂问题 当前结核病流行的沉重负担和持续性需要跨学科的伙伴关系; 动员技术进行识别、干预和预防;指导未来的科学家， 临床医生UCSF-UCB TRAC具有独特的优势，可以应对这些挑战， 更好的诊断和有效的疫苗。UCSF和UCB是NIH资助的 结核病研究与许多实验室在广泛的学科，和UCSF-UCB TRAC将填补一个关键的 在突出的临床和基础科学研究环境的差距。我们拟议的UCSF-UCB TRAC将允许 我们将：（1）通过提供试点奖励、培训、纵向培训和培训，吸引和支持结核病领域的新研究者（NI） 指导和其他关键服务和资源;以及（2）吸引并使非结核病调查人员能够进入 通过提供奖项，关键资源和多学科合作的机会，支持新的 结核病研究的方向。此外，我们的中心紧密集成了4个核心：1）行政核心， 领导、基础设施、行政和通信支助、咨询和监督，以协调所有 UCSF-UCB TRAC业务; 2）基础科学核心，以减少调查人员遇到的传统障碍 通过一套尖端技术促进创新的、多学科的、基础的结核病研究 可在BSL-3/ABSL-3设施访问; 3）临床科学核心，以增加现有的UCSF和UCB资源 通过吸引新的研究者和减少进行高质量研究的障碍来加速临床研究， 创新临床研究;以及4）发展核心，以吸引和培养结核病研究领域的科学领导者 通过一个服务平台，支持结核病研究中的独立思想，提供指导， 专业发展，提案支持和研究资金。UCSF-UCB TRAC将增加 强大的研究企业UCSF和加州大学伯克利分校之间的桥梁基础和传统的筒仓 临床结核病，并为结核病研究资源的协调和 两个校区和附属的国际研究中心。

PROJECT SUMMARY The overall goal of the proposed UC San Francisco – UC Berkeley Tuberculosis Research Advancement Center (UCSF-UCB TRAC) is to accelerate the pace of discoveries that improve our understanding of tuberculosis (TB) and lead directly to new tools for diagnosis, prevention, and treatment of TB. Addressing the complex problems of the current heavy burden and persistence of the TB epidemic requires partnerships across disciplines; mobilization of technology for identification, intervention, and prevention; and mentoring of future scientists and clinicians. The UCSF-UCB TRAC is uniquely positioned to address these challenges for radically new treatments, better diagnostics and an effective vaccine. UCSF and UCB represent a major hub of NIH-funded TB research with many labs across the wide spectrum of disciplines, and the UCSF-UCB TRAC will fill a critical gap in a prominent clinical and basic science research environment. Our proposed UCSF-UCB TRAC will allow us to, (1) attract and support New Investigators (NI) in the TB field by providing pilot awards, training, longitudinal mentorship and other key services and resources; and (2) attract and enable non-TB investigators to enter the field by providing awards, key resources and opportunities for multidisciplinary collaboration that support new directions in TB research. Further, our Center tightly integrates 4 cores: 1) an Administrative Core to provide leadership, infrastructure, administrative and communication support, advice and oversight to coordinate all UCSF-UCB TRAC operations; 2) a Basic Science Core to lower traditional barriers experienced by investigators to facilitate innovative, multidisciplinary, fundamental TB research through a suite of cutting edge technologies accessible in BSL-3/ABSL-3 facilities; 3) a Clinical Science Core to augment existing UCSF and UCB resources to accelerate clinical research by engaging new investigators and reducing the barrier to conducting high-quality, innovating clinical research; and 4) a Developmental Core to attract and develop scientific leaders in TB research via a platform of services to support a continuum of ideas to independence in TB research, offering mentoring, professional development, proposal support, and research funding. The UCSF-UCB TRAC will add value to the robust research enterprises of UCSF and UC Berkeley by bridging traditional silos between fundamental and clinical TB and by providing a nucleating factor for coordinated TB research resources and collaboration at the two campuses and at affiliated international research sites.