UCSF-UCB Tuberculosis Research Advancement Center (TRAC)

项目总结 加州大学旧金山分校-加州大学伯克利分校结核病研究促进中心的总体目标 (加州大学旧金山分校-UCB TRAC)将加快发现的步伐，以提高我们对结核病(TB)的了解 并直接导致诊断、预防和治疗结核病的新工具。解决复杂的问题 目前结核病流行的沉重负担和持久性需要跨学科的伙伴关系； 调动用于识别、干预和预防的技术；以及指导未来的科学家和 临床医生。加州大学旧金山分校-UCB TRAC具有独特的地位，可以应对这些全新的挑战 治疗、更好的诊断和有效的疫苗。加州大学旧金山分校和联合银行是NIH资助的主要枢纽 与广泛学科的许多实验室进行的结核病研究，以及加州大学旧金山分校-UCB TRAC将填补关键 突出的临床和基础科学研究环境中的差距。我们提议的加州大学旧金山分校-UCB TRAC将允许 美国将，(1)通过提供试点奖励、培训、纵向培训等方式吸引和支持结核病领域的新研究人员 指导和其他主要服务和资源；以及(2)吸引和使非结核病调查人员能够进入 通过提供奖项、关键资源和多学科协作机会来支持新的 结核病研究的方向。此外，我们的中心紧密集成了4个核心：1)管理核心，以提供 领导、基础设施、行政和沟通支持、咨询和监督，以协调所有 加州大学旧金山分校-UCB TRAC业务；2)降低调查人员面临的传统障碍的基础科学核心 通过一套尖端技术促进创新的、多学科的基础结核病研究 可在BSL-3/ABSL-3设施中使用；3)临床科学核心，以增强现有的加州大学旧金山分校和UCB资源 通过聘用新的研究人员和降低进行高质量研究的障碍来加快临床研究， 创新临床研究；以及4)开发核心，以吸引和培养结核病研究领域的科学领军人物 通过一个服务平台来支持结核病研究的独立性、提供指导、 专业发展、提案支持和研究资金。加州大学旧金山分校-UCB TRAC将为 加州大学旧金山分校和加州大学伯克利分校通过弥合基础和 通过为协调的结核病研究资源和合作提供核心因素 两个校区和附属的国际研究地点。

PROJECT SUMMARY The overall goal of the proposed UC San Francisco – UC Berkeley Tuberculosis Research Advancement Center (UCSF-UCB TRAC) is to accelerate the pace of discoveries that improve our understanding of tuberculosis (TB) and lead directly to new tools for diagnosis, prevention, and treatment of TB. Addressing the complex problems of the current heavy burden and persistence of the TB epidemic requires partnerships across disciplines; mobilization of technology for identification, intervention, and prevention; and mentoring of future scientists and clinicians. The UCSF-UCB TRAC is uniquely positioned to address these challenges for radically new treatments, better diagnostics and an effective vaccine. UCSF and UCB represent a major hub of NIH-funded TB research with many labs across the wide spectrum of disciplines, and the UCSF-UCB TRAC will fill a critical gap in a prominent clinical and basic science research environment. Our proposed UCSF-UCB TRAC will allow us to, (1) attract and support New Investigators (NI) in the TB field by providing pilot awards, training, longitudinal mentorship and other key services and resources; and (2) attract and enable non-TB investigators to enter the field by providing awards, key resources and opportunities for multidisciplinary collaboration that support new directions in TB research. Further, our Center tightly integrates 4 cores: 1) an Administrative Core to provide leadership, infrastructure, administrative and communication support, advice and oversight to coordinate all UCSF-UCB TRAC operations; 2) a Basic Science Core to lower traditional barriers experienced by investigators to facilitate innovative, multidisciplinary, fundamental TB research through a suite of cutting edge technologies accessible in BSL-3/ABSL-3 facilities; 3) a Clinical Science Core to augment existing UCSF and UCB resources to accelerate clinical research by engaging new investigators and reducing the barrier to conducting high-quality, innovating clinical research; and 4) a Developmental Core to attract and develop scientific leaders in TB research via a platform of services to support a continuum of ideas to independence in TB research, offering mentoring, professional development, proposal support, and research funding. The UCSF-UCB TRAC will add value to the robust research enterprises of UCSF and UC Berkeley by bridging traditional silos between fundamental and clinical TB and by providing a nucleating factor for coordinated TB research resources and collaboration at the two campuses and at affiliated international research sites.