RESEARCH PROJECT 2

研究项目2

基本信息

  • 批准号:
    10224018
  • 负责人:
  • 金额:
    $ 9.57万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-08-17 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

PROJECT 2: GENETIC IDENTIFICATION OF HOST INNATE PATHWAYS THAT CONTROL BACTERIAL PATHOGENESIS SUMMARY Phagocytes of the mammalian innate immune system, in particular macrophages and neutrophils, form the first line of defense upon bacterial infection and are armed with powerful mechanisms to limit bacterial growth and eradicate invaders. Bacterial pathogens, however, have evolved mechanisms to thwart these killing mechanisms of phagocytes, and to persist in human tissues. In addition to having direct antimicrobial activity, macrophages and neutrophils also initiate and shape powerful inflammatory responses that dramatically influence disease. Indeed, the inflammatory pathways elicited by each of the pathogens involved in this study - Mycobacterium tuberculosis (Mtb), Staphylococcus aureus (SA), and Chlamydia trachomatis (CT) - play major roles in bacterial persistence in tissues and in promoting disease. Pathogens must subvert these cells in order to grow and persist, but the host genes and cellular pathways that dictate the outcome of infection are not entirely clear. The broad idea of this proposal is to use unbiased, systematic approaches to probe the intimate interactions between pathogen and innate immune cells, and to use this information to make predictions about bacterial infectivity that will be tested in human samples in an iterative fashion to model host response during infection. We propose to systematically identify innate immune gene networks that underlie pathogenesis in clinically relevant model systems of infections with these three important bacterial pathogens. Using powerful CRISPR-based knockout strategies in both ex vivo infections and in mouse models, coupled with innovative approaches to identify functionally relevant polymorphisms in clinical samples, we seek to dramatically increase our understanding of infection biology of humans. We anticipate that these insights, coupled with the other elements of the HPMI Center, will point to novel vulnerabilities with therapeutic relevance.
项目二:宿主先天途径的遗传鉴定

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

JEFFERY S COX其他文献

JEFFERY S COX的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('JEFFERY S COX', 18)}}的其他基金

UCSF-UCB Tuberculosis Research Advancement Center (TRAC)
UCSF-UCB 结核病研究促进中心 (TRAC)
  • 批准号:
    10431539
  • 财政年份:
    2022
  • 资助金额:
    $ 9.57万
  • 项目类别:
UCSF-UCB Tuberculosis Research Advancement Center (TRAC)
UCSF-UCB 结核病研究促进中心 (TRAC)
  • 批准号:
    10674698
  • 财政年份:
    2022
  • 资助金额:
    $ 9.57万
  • 项目类别:
M. tuberculosis strain-dependent interactions with host cells
结核分枝杆菌与宿主细胞的菌株依赖性相互作用
  • 批准号:
    10459539
  • 财政年份:
    2021
  • 资助金额:
    $ 9.57万
  • 项目类别:
M. tuberculosis strain-dependent interactions with host cells
结核分枝杆菌与宿主细胞的菌株依赖性相互作用
  • 批准号:
    10653910
  • 财政年份:
    2021
  • 资助金额:
    $ 9.57万
  • 项目类别:
Host Pathogen Variation & TB Pathogenesis
宿主病原体变异
  • 批准号:
    10459534
  • 财政年份:
    2021
  • 资助金额:
    $ 9.57万
  • 项目类别:
Host Pathogen Variation & TB Pathogenesis
宿主病原体变异
  • 批准号:
    10271168
  • 财政年份:
    2021
  • 资助金额:
    $ 9.57万
  • 项目类别:
M. tuberculosis strain-dependent interactions with host cells
结核分枝杆菌与宿主细胞的菌株依赖性相互作用
  • 批准号:
    10271172
  • 财政年份:
    2021
  • 资助金额:
    $ 9.57万
  • 项目类别:
Host Pathogen Variation & TB Pathogenesis
宿主病原体变异
  • 批准号:
    10653900
  • 财政年份:
    2021
  • 资助金额:
    $ 9.57万
  • 项目类别:
PROJECT 1: Identification of host and bacterial pathways that control tuberculosis pathogenesis in humans
项目 1:鉴定控制人类结核病发病机制的宿主和细菌途径
  • 批准号:
    10550001
  • 财政年份:
    2018
  • 资助金额:
    $ 9.57万
  • 项目类别:
Research Training at the Confluence of Infectious and Non-Communicable Diseases in India
印度传染病和非传染性疾病交汇处的研究培训
  • 批准号:
    10361555
  • 财政年份:
    2017
  • 资助金额:
    $ 9.57万
  • 项目类别:

相似海外基金

New roles of IFN-inducible OAS proteins in innate immune defense against bacterial infections
IFN诱导的OAS蛋白在针对细菌感染的先天免疫防御中的新作用
  • 批准号:
    10649771
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
Derivation and validation of a clinical prediction rule to identify febrile infants 61 to 90 days old at low and non-negligible risk of invasive bacterial infections
推导和验证临床预测规则,以识别 61 至 90 天大的发热婴儿,其侵袭性细菌感染的风险较低且不可忽略
  • 批准号:
    10574286
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
Structural and functional studies of YbtPQ for fighting bacterial infections
YbtPQ 对抗细菌感染的结构和功能研究
  • 批准号:
    10644889
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
A gut feeling: How can gastrointestinal bacterial infections alter female reproductive tract immunity and control of sexually transmitted infections
直觉:胃肠道细菌感染如何改变女性生殖道免疫力和性传播感染的控制
  • 批准号:
    MR/X031993/1
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
    Research Grant
Molecular probes to diagnose pathoadapatations in bacterial infections
诊断细菌感染病理适应的分子探针
  • 批准号:
    EP/X014479/1
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
    Research Grant
Using Small Area Variation Analysis to Investigate Sources of Practice Variation for Febrile Infants at Risk for Invasive Bacterial Infections
使用小面积变异分析来调查有侵袭性细菌感染风险的发热婴儿的实践变异来源
  • 批准号:
    10588846
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
Host Directed Orynotide for MDR Gram Negative Bacterial Infections
宿主定向 Orynotide 用于治疗耐多药革兰氏阴性细菌感染
  • 批准号:
    10674221
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
SimCell vaccines against Staphylococcus aureus bacterial infections
针对金黄色葡萄球菌细菌感染的 SimCell 疫苗
  • 批准号:
    10073241
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
    Grant for R&D
I-Corps: Mitigating Multidrug Resistant Bacterial Infections with Biocompatible and Environmentally Benign Nanoantibiotics
I-Corps:利用生物相容性且对环境无害的纳米抗生素减轻多重耐药细菌感染
  • 批准号:
    2306943
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
    Standard Grant
Multidimensional development of high-affinity anti-glycan antibodies to fight deadly bacterial infections
多维开发高亲和力抗聚糖抗体以对抗致命细菌感染
  • 批准号:
    10549640
  • 财政年份:
    2023
  • 资助金额:
    $ 9.57万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了