Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort & Biobank

项目总结/摘要 这项建议是继续纵向随访的人口为基础的密歇根州狼疮流行病学& 监测（MILES）计划队列和生物库。总体目标是前瞻性地收集数据， 生物标本，将允许全面调查有关的风险因素狼疮发作， 进展和合并症。迄今为止，基线一轮的队列访问已经完成， 后续访问正在进行中。详细的数据收集包括与以下方面有关的措施： 社会人口统计学、健康/保健、生殖健康、身体功能、环境暴露、生活方式 因素和基因。测量SLE的狼疮特异性指标，包括疾病活动指数 例最先进的生物样本库包括血清、血浆、DNA/RNA（来自淋巴细胞亚群）、尿液、毛发、 还有剪下的脚趾甲生物样本库样本在适当条件下处理和储存，以提供 进行检测的能力，包括现代免疫检测、疾病和暴露的生物标志物，以及 相关淋巴细胞亚群的DNA甲基化。MILES队列和生物库的主要专题领域 旨在支持包括表观遗传学，环境流行病学，和肾狼疮。MILES队列将 因此，作为一个强大的平台，为正在进行的和未来的研究调查，是相关的全面 狼疮谱及其并发症。

PROJECT SUMMARY/ABSTRACT This proposal is to continue longitudinal follow-up of the population-based Michigan Lupus Epidemiology & Surveillance (MILES) Program Cohort and Biobank. The overarching goal is to prospectively collect data and biospecimens that will allow for comprehensive investigations related to risk factors for lupus onset, progression, and comorbidities. To date, the baseline round of Cohort visits has been completed, and the first follow-up round of visits is ongoing. Detailed data collection encompasses measures related to sociodemographics, health/wellness, reproductive health, physical function, environmental exposures, lifestyle factors, and genetics. Lupus-specific measures, including disease activity indices, are measured for the SLE cases. The state-of-the-art biobank includes serum, plasma, DNA/RNA (from lymphocyte subsets), urine, hair, and toenail clippings. Biobank specimens are processed and stored in appropriate conditions to provide the capacity to perform assays including contemporary immunoassays, biomarkers of disease and exposure, and DNA methylation of relevant lymphocyte subsets. Major thematic areas that the MILES Cohort & Biobank is designed to support include epigenetics, environmental epidemiology, and renal lupus. The MILES Cohort will thus serve as a robust platform for ongoing and future research investigations that are relevant to the full spectrum of lupus and its complications.