Interdisciplinary Training in Auditory Neuroscience

听觉神经科学跨学科培训

• 批准号: 10200754
• 负责人: Michael G Heinz
• 金额: $ 18.83万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200754
• 关键词: Auditory; Neurosciences; Training

PROJECT SUMMARY/ABSTRACT There is a national need to advance the understanding of hearing in both healthy patients and those with various causes of hearing loss. The objective of the proposed program is to train the next generation of faculty who could populate colleges of science, engineering, and health sciences, as well as to send graduates into in order to advance auditory neuroscience training, this new graduate program will leverage faculty expertise in basic hearing science and technology development, from three Purdue University colleges (Science, Engineering, and Health & Human Sciences) and 6 doctoral admissions programs. Two types of investigators are included in the training program: 10 hearing scientists with focused research programs related to auditory system neuroscience, and 7 technology innovators who are trained in other disciplines (electrical, computer and biomedical engineering, and chemistry). Collectively and collaboratively, the program will expand knowledge about mechanisms at the molecular, cellular and systems levels that underlie auditory information processing. This fundamental knowledge can then be applied to better understand the changes that lead to pathologies of the auditory system due to damage, disease, aging, and congenital disorders, as well as understanding how hearing evolved and influences behavior and natural selection. Technological approaches to these questions include, but are not limited to, fluorescent sensors to detect purinergic signaling in the intact nervous system, biological implants for neuromodulation, high-resolution four-dimension calcium imaging deep in the mammalian brain, optogenetics and robotics (automated patch-clamping) for brain circuit analysis, and industry prepared to work toward creative solutions for treating hearing loss. Specifically, This training program is unique in that it is specifically designed to serve students with undergraduate degrees in the disparate disciplines of life science, physical science or engineering, and merge them into a unified cohort focused on auditory neuroscience. Students will be selected for a 2-year term on the training grant, beginning at the start of their second year. The training curriculum includes 3 core courses (one each in neuroscience, the auditory periphery, and signal processing), several recommended courses (e.g., in neurosurgery or neuroscience), a weekly Hearing Science seminar series, and yearly attendance at extramural hearing-related courses and/or auditory neuroscience conferences. In addition to administrative support for the program, the Purdue Institute for Integrative Neuroscience will provide students with additional resources, such as supervised grant writing, hands-on training in animal behavior and human stem cells, annual neuroscience retreats, and access to in-house competitions for travel grants and pilot funding for collaborative projects. Further, this program builds on Purdue's extensive history in training graduate students in collaborative research (particularly in hearing science and technology development), and preparing these students for successful research careers in academia, industry and the clinic. multimodal brain imaging methods.

项目摘要/摘要 有必要在全国范围内促进对健康患者和有听力障碍患者听力的理解。 导致听力损失的各种原因。 拟议方案的目标是培养下一代教师。 谁可以让科学、工程和健康科学学院入学，以及把毕业生送到 为了晋级 听力神经科学培训，这一新的研究生课程将利用教师在基础听力方面的专业知识 科学和技术发展，来自普渡大学的三所学院(科学、工程和 健康与人文科学)和6个博士招生项目。两种类型的调查人员包括在 培训计划：10名听力科学家，重点研究与听觉系统有关的项目 神经科学，以及7名受过其他学科培训的技术创新者(电气、计算机和 生物医学工程和化学)。通过集体和协作，该计划将扩大知识 关于分子、细胞和系统层面的机制，这些机制是听觉信息处理的基础。 这些基础知识可以用来更好地理解导致脑血管病变的变化。 由于损伤、疾病、衰老和先天性疾病而导致的听觉系统，以及理解如何 听觉进化并影响行为和自然选择。解决这些问题的技术途径 包括但不限于检测完整神经系统中的嘌呤能信号的荧光传感器， 用于神经调节的生物植入物，深部高分辨率四维钙成像 用于大脑电路分析的哺乳动物大脑、光遗传学和机器人(自动膜片钳)，以及 业界准备努力寻找治疗听力损失的创造性解决方案。具体来说， 这一培训计划的独特之处在于它是专门为 拥有生命科学、物理科学或其他不同学科本科学位的学生 工程学，并将它们合并为一个专注于听觉神经科学的统一队列。学生将被挑选出来 培训补助金为期两年，从第二年开始。培训课程 包括3门核心课程(神经科学、听觉外围设备和信号处理各一门)， 推荐课程(例如，神经外科或神经科学)，每周一次的听力科学研讨会系列，以及 每年参加与听力有关的校外课程和/或听神经科学会议。此外 为了对该项目提供行政支持，普渡综合神经科学研究所将提供 有额外资源的学生，如受监督的助学金撰写、动物行为实践培训和 人类干细胞，一年一度的神经科学务虚会，以及获得旅行补助金和 开展合作项目资金试点。此外，该计划建立在普渡大学广泛的培训历史基础上 研究生合作研究(特别是听力科学和技术发展)，以及 为这些学生在学术界、工业界和临床上成功的研究生涯做准备。 多模式脑成像方法。