High-performance compact 3T MRI: Technical optimization for advanced brain imaging

项目摘要/摘要 一款突破性的轻巧紧凑的3T磁共振扫描仪已被证明具有 700T/m/S的回转速率，以80mT/m的幅度工作)，这是一种比全身快3.5倍的回转速率 核磁共振检查。拟议的下一阶段计划将通过多学科提供关键的神经成像工具 梅奥诊所和GE全球研究公司之间的合作。这项拟议的工作包括在图像重建、系统伪影校正和脉冲序列编程方面的进一步技术开发 紧凑型3T独特的高性能性能。 该项目的具体目标是： ·目标1)在紧凑型3T上开发回声平面成像(EPI)核心技术 ·目标2)开发新的基于MRI的连接 ·目标3)开发高分辨率磁共振弹性成像(MRE)脑僵硬测量 目标1专注于改进紧凑型3T系统的EPI，以最大限度地利用其独特的梯度 回转率和比吸收率(SAR)优势。与这一目标有关的具体任务包括：开发基于模型的重建、消除伴随的现场伪影的实时系统补偿、 用于分段EPI的脉冲序列开发用于非常快速的解剖成像，并通过利用SAR的优势提高同时多层(SMS)的效率。 目的2利用紧凑的3T在内侧颞叶区域显著降低的敏感性伪影，实现对整个大脑的无任务功能磁共振自发协同研究，包括海马体，这是阿尔茨海默病(AD)研究的核心。 目标3描述了紧凑型3T的高性能渐变如何首次实现3D渐变 基于回声的磁共振弹性成像(3DMRE)。这将使获取的体素大小减少到原来的1/8 用我们的全身核磁共振目前获得的2DMRE。这具有重要的应用，而不仅仅是 手术前计划肿瘤切除，但也可能开发新的生物标记物研究神经变性疾病，如阿尔茨海默病。新的3DMRE技术将在与AIM相同的患者队列中进行研究 2.我们相信，在紧凑型3T MR平台上大幅提高空间分辨率和扫描效率将使 评估包括创伤性脑在内的脑部疾病管理的新临床和神经科学应用 损伤、肿瘤治疗计划和神经退行性疾病。

PROJECT SUMMARY/ABSTRACT A breakthrough lightweight, compact 3T MR scanner has been demonstrated to have gradient performance of 700 T/m/s slew rate, operating at 80 mT/m amplitude), which is a slew rate that is 3.5x faster than whole-body MRIs. The proposed next phase of the program will deliver key neuroimaging tools through a multi-disciplinary collaboration between Mayo Clinic and GE Global Research. This proposed work includes further technical development in image reconstruction, systems artifact correction, and pulse sequence programming that exploits the unique, high-performance capabilities of the compact 3T. The Specific Aims of the project are to: · Aim 1) Develop Core Technologies for Echo Planar Imaging (EPI) on the Compact 3T · Aim 2) Develop New MRI-based Connectomics · Aim 3) Develop High-Resolution MR Elastography (MRE) Brain Stiffness Measurement Aim 1 focuses on improving EPI on the compact 3T system to maximally capitalize on its unique gradient slew rate and specific absorption rate (SAR) advantages. Specific tasks related to this aim include: the development of model-based reconstructions, real-time system compensation to eliminate concomitant field artifacts, pulse sequence development for segmented EPI for very fast anatomical imaging, and improved efficiency for simultaneous multislice (SMS) by exploiting the SAR advantages. Aim 2 exploits the compact 3T's dramatically reduced susceptibility artifacts in the region of the medial temporal lobe to enable task-free fMRI spontaneous coactiviation studies of the entire brain, including the hippocampus, which is central to the study of Alzheimer's disease (AD). Aim 3 describes how the compact 3T's high-performance gradients enable, for the first time, 3D gradient echo-based MR elastography (3DMRE). This will enable an 8x reduction in the acquired voxel size compared with the 2DMRE currently acquired with our whole-body MRIs. This has important applications, not-only to pre-surgical planning for tumor resection, but also to potentially develop new biomarkers for the study of neurodenegerative disease, such as AD. The new 3DMRE technique will be studied in the same patient cohort as Aim 2. We believe vastly improved spatial resolution and scan efficiency on the compact 3T MR platform will enable new clinical and neuroscience applications for assessing brain disease management, including traumatic brain injury, tumor treatment planning, and neurodegenerative diseases.