High Performance, Highly Deployable Head-Only MRI Scanner

高性能、高度可部署的头部 MRI 扫描仪

• 批准号: 9026763
• 负责人: MATTHEW A. BERNSTEIN
• 金额: $ 9.96万
• 依托单位: GENERAL ELECTRIC GLOBAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9026763
• 关键词: Accident and Emergency department; Autistic Disorder; Beds; Brain; Brain Diseases; Brain Injuries; Businesses; Clinic; Clinical; Clinical Research; Collaborations; Consultations; Development; Devices; Diagnostic; Engineering; Evaluation; Floor; Functional Magnetic Resonance Imaging; Future; Goals; Government; Head; Health; Healthcare; Heating; Hospitals; Human; Human Volunteers; Image; Image Analysis; Imaging Techniques; Institutional Review Boards; Investments; Lead; Location; Magnetic Resonance; Magnetic Resonance Imaging; Mental Depression; Mental disorders; Military Medicine; Motivation; Nonhospital Ambulatory Care Facilities; Patients; Performance; Peripheral; Peripheral Nerve Stimulation; Persons; Physiologic pulse; Positioning Attribute; Power Sources; Procedures; Process; Protocols documentation; Radiology Specialty; Research; Research Personnel; Rural Population; Scanning; Scientist; Sensory; Services; Site; Speed; Staging; Stroke; System; Techniques; Technology; Testing; Time; Traumatic Brain Injury; United States National Institutes of Health; Weight; base; clinically relevant; combat; cryogenics; cryostat; density; design; ergonomics; flexibility; imaging system; improved; light weight; meetings; nervous system disorder; neuroimaging; novel; operation; programs; prototype; radio frequency; simulation; volunteer; whole body imaging

DESCRIPTION (provided by applicant): The motivation for the proposed program is the realization that the current multi-use whole-body MRI scanners limit optimal neuroimaging. Current scanners are based on the one-size-fits-all concept of whole-body imaging and do not have the full range of functionalities that could be achieved in a scanner designed to image only the brain. GE Global Research and the Mayo Clinic propose to jointly develop and validate a radically new MR system optimized for neuroimaging. This system is based on a revolutionary lightweight magnet, gradient and RF design to permit high quality 3T MRI of the human brain. This new scanner will provide much greater patient comfort, markedly improved image quality, and much higher performance in terms of speed and range of imaging capabilities such as gradient strength and slew rate. In addition, the significant reduction in size and weight will allow the placement of the scanner in locations that are currently inaccessible to whole-body MRI scanners. This program will develop: 1) Enabling cryogen-free magnet and gradient technologies include advanced cryogenic and magnet design, head-only high-performance gradients, an RF coil with integrated fMRI simulation capabilities, and optimized patient ergonomics. 2) A high-performance prototype 3T head-only imaging system, that will be evaluated on human volunteers. 3) Optimized image acquisition protocols and image analysis technology to permit improved assessment of brain disorders.

描述（由申请人提供）：拟议项目的动机是认识到当前的多用途全身 MRI 扫描仪限制了最佳神经成像。当前的扫描仪基于全身成像的一刀切概念，不具备仅对大脑进行成像的扫描仪可以实现的全部功能。 GE 全球研究中心和梅奥诊所提议联合开发和验证针对神经影像优化的全新 MR 系统。该系统基于革命性的轻质磁铁、梯度和射频设计，可实现人脑的高质量 3T MRI。这款新型扫描仪将提供更大的患者舒适度、显着改善的图像质量以及在速度和成像功能范围（例如梯度强度和转换速率）方面更高的性能。此外，尺寸和重量的显着减小将允许将扫描仪放置在目前全身 MRI 扫描仪无法到达的位置。 该计划将开发：1）实现无冷冻剂磁体和梯度技术，包括先进的低温和磁体设计、头部高性能梯度、具有集成功能磁共振成像功能的射频线圈以及优化的患者人体工程学。 2) 高性能 3T 头部成像系统原型，将在人类志愿者身上进行评估。 3) 优化图像采集协议和图像分析技术，以改进对大脑疾病的评估。

项目成果

Peripheral nerve stimulation characteristics of an asymmetric head-only gradient coil compatible with a high-channel-count receiver array.

• DOI: 10.1002/mrm.26044
• 发表时间: 2016-12
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Lee SK;Mathieu JB;Graziani D;Piel J;Budesheim E;Fiveland E;Hardy CJ;Tan ET;Amm B;Foo TK;Bernstein MA;Huston J 3rd;Shu Y;Schenck JF
• 通讯作者: Schenck JF