Noninvasive Pesticide Biomonitoring Using Sweat Patches

使用汗贴进行非侵入性农药生物监测

基本信息

  • 批准号:
    10371353
  • 负责人:
  • 金额:
    $ 23.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Chronic low-dose exposure to agricultural pesticides is widely accepted as a fundamental health threat to farmworkers. Unfortunately, delineating sources of variation in pesticide exposure among farmworkers and the long-term consequences of pesticide exposure is hampered by measurement challenges, particularly the absence of an easy, nonintrusive strategy for pesticide biomonitoring. Sweat patches offer a compelling alternative for assessing exposure to pesticides in field studies. Evidence indicates that pesticide metabolites are found in sweat, and sweat patches are being used routinely now in drug monitoring studies. The goal of this interdisciplinary study is to determine the feasibility of using sweat patches for biomonitoring pesticide exposure among Latino farmworkers. We will test the hypothesis that sweat patch sampling will allow for sensitive and consistent measurements with a high rate of compliance. The aims of this feasibility study are to: 1) develop and assess the accuracy and precision of laboratory techniques used to measure pesticides and their metabolites extracted from sweat patches and 2) determine the levels and variance in concentrations of pesticides and metabolites obtained from sweat to those obtained from urine. A secondary aim is to document challenges and problems experienced by farmworkers in using (e.g., opening, applying, wearing removing, and storing) the sweat patches. Advantages of sweat patches to traditional urine screening include the patch being noninvasive, showing increased compliance, and reducing financial cost for future research in this field. Our proposed work involves a combination of both laboratory and field procedures, and the subsequent integration will result in a highly translational project with substantial occupational health impact.
项目概要 长期低剂量接触农用农药被广泛认为是对人类健康的根本威胁 农场工人。不幸的是,描绘了农场工人和农民之间农药接触差异的来源。 农药暴露的长期后果受到测量挑战的阻碍,特别是 缺乏简单、非侵入性的农药生物监测策略。汗贴提供了引人注目的 在实地研究中评估农药暴露的替代方案。有证据表明农药代谢物 在汗液中发现,汗贴现在已常规用于药物监测研究。此举的目标 跨学科研究旨在确定使用汗贴进行农药暴露生物监测的可行性 在拉丁裔农场工人中。我们将检验这样的假设:汗斑取样将允许敏感和 测量结果一致,符合率高。本可行性研究的目的是: 1) 开发和 评估用于测量农药及其代谢物的实验室技术的准确性和精密度 从汗斑中提取,2) 确定农药浓度的水平和变化, 从汗液中获得的代谢物到从尿液中获得的代谢物。第二个目标是记录挑战和 农场工人在使用(例如打开、使用、佩戴、拆卸和储存)过程中遇到的问题 汗斑。汗贴相对于传统尿液筛查的优点包括汗贴是非侵入性的, 显示出更高的合规性,并降低了该领域未来研究的财务成本。我们提议的工作 涉及实验室和现场程序的结合,随后的整合将导致 具有重大职业健康影响的高度转化项目。

项目成果

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JOSEPH G. GRZYWACZ其他文献

JOSEPH G. GRZYWACZ的其他文献

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{{ truncateString('JOSEPH G. GRZYWACZ', 18)}}的其他基金

Occupational Safety and Health Research (R01)
职业安全与健康研究(R01)
  • 批准号:
    10274305
  • 财政年份:
    2020
  • 资助金额:
    $ 23.1万
  • 项目类别:
Occupational Safety and Health Research (R01)
职业安全与健康研究(R01)
  • 批准号:
    10411877
  • 财政年份:
    2020
  • 资助金额:
    $ 23.1万
  • 项目类别:
Occupational Safety and Health Research (R01)
职业安全与健康研究(R01)
  • 批准号:
    10250712
  • 财政年份:
    2020
  • 资助金额:
    $ 23.1万
  • 项目类别:
Engaging Families and Employers in Latino Construction Worker Injury Prevention
让家庭和雇主参与拉丁裔建筑工人伤害预防
  • 批准号:
    9448505
  • 财政年份:
    2019
  • 资助金额:
    $ 23.1万
  • 项目类别:
Nonstandard Maternal Work Schedules & Child Health in Impoverished Families
不标准的产妇工作时间表
  • 批准号:
    8053354
  • 财政年份:
    2010
  • 资助金额:
    $ 23.1万
  • 项目类别:
Nonstandard Maternal Work Schedules & Child Health in Impoverished Families
不标准的产妇工作时间表
  • 批准号:
    7791633
  • 财政年份:
    2010
  • 资助金额:
    $ 23.1万
  • 项目类别:
Dietary & Physical Activity Patterns of Latino Farmworker Children
饮食
  • 批准号:
    7928931
  • 财政年份:
    2009
  • 资助金额:
    $ 23.1万
  • 项目类别:
Dietary & Physical Activity Patterns of Latino Farmworker Children
饮食
  • 批准号:
    7714068
  • 财政年份:
    2009
  • 资助金额:
    $ 23.1万
  • 项目类别:
Women's physical activity and eating habits: Influence of work-family balance
女性体力活动和饮食习惯:工作与家庭平衡的影响
  • 批准号:
    7729075
  • 财政年份:
    2008
  • 资助金额:
    $ 23.1万
  • 项目类别:
Weaving Work and Family: Implications for Mother and Child
工作与家庭的交织:对母亲和孩子的影响
  • 批准号:
    7141464
  • 财政年份:
    2007
  • 资助金额:
    $ 23.1万
  • 项目类别:

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