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MECHANISTIC ROLE OF CHOLESTEROL IN NON-ALCOHOLIC STEATOHEPATITIS

MECHANISTIC ROLE OF CHOLESTEROL IN NON-ALCOHOLIC STEATOHEPATITIS
胆固醇在非酒精性脂肪性肝炎中的机制作用
批准号:
nhmrc : 585411
负责人:
Prof Geoffrey Farrell
金额:
$35.58万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2013-12-31

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中文摘要
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英文摘要
Fatty liver is present in 15-30% of Australians, related to obesity, diabetes and heart attack. Two-thirds of cases reverse easily. The remainder evolve to non-alcoholic steatohepatitis (NASH), liver damage that can lead to cirrhosis and liver failure. This research seeks to find out why some cases of fatty liver lead to NASH, and whether cholesterol that accumulates in the livers of mice with NASH is what causes that damage. If so, we will find new ways to treat NASH by diet or drugs.
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Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
  • 批准号:
    nhmrc : GNT1084136
  • 项目类别:
    Project Grants
  • 资助金额:
    $41.64万
  • 财政年份:
    2015
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
  • 批准号:
    nhmrc : 1084136
  • 项目类别:
    Project Grants
  • 资助金额:
    $28.65万
  • 财政年份:
    2015
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
Microparticles in NASH: origins, pathogenic roles, and biomarker of disease activity
  • 批准号:
    nhmrc : 1044288
  • 项目类别:
    Project Grants
  • 资助金额:
    $36.05万
  • 财政年份:
    2013
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
Significance of microparticles in the pathogenesis of liver ischemia reperfusion injury
  • 批准号:
    nhmrc : 1008958
  • 项目类别:
    Project Grants
  • 资助金额:
    $42.94万
  • 财政年份:
    2011
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
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