MECHANISTIC ROLE OF CHOLESTEROL IN NON-ALCOHOLIC STEATOHEPATITIS

胆固醇在非酒精性脂肪性肝炎中的机制作用

• 批准号: nhmrc : 585411
• 负责人: Prof Geoffrey Farrell
• 金额: $ 35.58万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanistic-role-cholesterol-alcoholic-steatohepatitis/100160
• 关键词: MECHANISTIC; ROLE; CHOLESTEROL; NON; ALCOHOLIC

Fatty liver is present in 15-30% of Australians, related to obesity, diabetes and heart attack. Two-thirds of cases reverse easily. The remainder evolve to non-alcoholic steatohepatitis (NASH), liver damage that can lead to cirrhosis and liver failure. This research seeks to find out why some cases of fatty liver lead to NASH, and whether cholesterol that accumulates in the livers of mice with NASH is what causes that damage. If so, we will find new ways to treat NASH by diet or drugs.

脂肪肝存在于15-30%的澳大利亚人中，与肥胖，糖尿病和心脏病发作有关。三分之二的病例很容易逆转。其余的发展为非酒精性脂肪性肝炎（NASH），肝损伤可导致肝硬化和肝功能衰竭。这项研究旨在找出为什么一些脂肪肝病例会导致NASH，以及在NASH小鼠肝脏中积累的胆固醇是否是导致这种损害的原因。如果是这样，我们将找到新的方法来治疗NASH的饮食或药物。