Protecting fatty livers from hepatic ischemia-reperfusion injury in liver surgery and transplantation

肝脏手术和移植中保护脂肪肝免受肝脏缺血再灌注损伤

• 批准号: nhmrc : 1010082
• 负责人: Prof Geoffrey Farrell
• 金额: $ 41.67万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protecting-fatty-livers-surgery-transplantation/109458
• 关键词: Protecting; fatty; livers; hepatic; ischemia

About one third of the population have a fatty liver, and this greatly increases risks of liver failure after liver surgery or when fatty donor livers are used for transplantation (such organs are currently disposed of). The disease process is called ischemia-reperfusion injury (IRI). The investigators have recently shown that both fibrates and statins provide partial protection against IRI in fatty livers. This research is directed at establish the protective mechanisms, and whether combination drugs are more effective.

大约三分之一的人患有脂肪肝，这极大地增加了肝脏手术后或脂肪供体肝脏用于移植(此类器官目前已被处理)后发生肝功能衰竭的风险。这一疾病过程称为缺血再灌注损伤(IRI)。研究人员最近表明，贝特类和他汀类药物对脂肪肝的IRI都有部分保护作用。这项研究旨在建立保护机制，以及联合用药是否更有效。