Significance of microparticles in the pathogenesis of liver ischemia reperfusion injury

微粒在肝脏缺血再灌注损伤发病机制中的意义

• 批准号: nhmrc : 1008958
• 负责人: Prof Geoffrey Farrell
• 金额: $ 42.94万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/significance-microparticles-pathogenesis-reperfusion-injury/109359
• 关键词: Significance; microparticles; pathogenesis; liver; ischemia

The overall aim of the project is to investigate the significance of microparticles in liver ischemia reperfusion injury (IRI). IRI causes damage to donor livers stored in preparation for liver transplantation. We postulate that microparticles released from the liver are critical in this form of injury. The expected outcomes are novel insights into liver IRI with the aim of developing new approaches to prevent liver damage during liver surgery, transplantation and shock.

该项目的总体目的是探讨微颗粒在肝脏缺血再灌注损伤（IRI）中的意义。IRI对为肝移植而储存的供肝造成损伤。我们假设从肝脏释放的微粒对这种形式的损伤至关重要。预期的结果是对肝脏IRI的新见解，目的是开发新的方法来预防肝手术，移植和休克期间的肝损伤。