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Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4

Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
肝脏脂毒性和 NASH:游离胆固醇、饱和 FFA、JNK1 和 TLR4 的机制作用
批准号:
nhmrc : 1084136
负责人:
Prof Geoffrey Farrell
金额:
$28.65万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31

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中文摘要
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英文摘要
Non-alcoholic fatty liver disease (NAFLD) occurs in overweight people, diabetes and with high blood pressure and raised cholesterol. This research is about how cholesterol in liver cells interacts with long chain fatty acids to cause injury and inflammation (steatohepatitis, NASH) in NAFLD.
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Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
  • 批准号:
    nhmrc : GNT1084136
  • 项目类别:
    Project Grants
  • 资助金额:
    $41.64万
  • 财政年份:
    2015
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
Microparticles in NASH: origins, pathogenic roles, and biomarker of disease activity
  • 批准号:
    nhmrc : 1044288
  • 项目类别:
    Project Grants
  • 资助金额:
    $36.05万
  • 财政年份:
    2013
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
Significance of microparticles in the pathogenesis of liver ischemia reperfusion injury
  • 批准号:
    nhmrc : 1008958
  • 项目类别:
    Project Grants
  • 资助金额:
    $42.94万
  • 财政年份:
    2011
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
Protecting fatty livers from hepatic ischemia-reperfusion injury in liver surgery and transplantation
  • 批准号:
    nhmrc : 1010082
  • 项目类别:
    Project Grants
  • 资助金额:
    $41.67万
  • 财政年份:
    2011
  • 负责人:
    Prof Geoffrey Farrell
  • 依托单位:
海外基金