Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
批准号:
nhmrc : 1084136
负责人:
Prof Geoffrey Farrell
金额:
$28.65万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
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英文摘要
Non-alcoholic fatty liver disease (NAFLD) occurs in overweight people, diabetes and with high blood pressure and raised cholesterol. This research is about how cholesterol in liver cells interacts with long chain fatty acids to cause injury and inflammation (steatohepatitis, NASH) in NAFLD.
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Liver lipotoxicity and NASH: mechanistic roles of free cholesterol, saturated FFA, JNK1 and TLR4
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批准号:nhmrc : GNT1084136
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项目类别:Project Grants
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资助金额:$41.64万
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财政年份:2015
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负责人:Prof Geoffrey Farrell
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依托单位:
Microparticles in NASH: origins, pathogenic roles, and biomarker of disease activity
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批准号:nhmrc : 1044288
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项目类别:Project Grants
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资助金额:$36.05万
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财政年份:2013
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负责人:Prof Geoffrey Farrell
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依托单位:
Significance of microparticles in the pathogenesis of liver ischemia reperfusion injury
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批准号:nhmrc : 1008958
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项目类别:Project Grants
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资助金额:$42.94万
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财政年份:2011
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负责人:Prof Geoffrey Farrell
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依托单位:
Protecting fatty livers from hepatic ischemia-reperfusion injury in liver surgery and transplantation
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批准号:nhmrc : 1010082
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项目类别:Project Grants
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资助金额:$41.67万
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财政年份:2011
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负责人:Prof Geoffrey Farrell
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依托单位:
MECHANISTIC ROLE OF CHOLESTEROL IN NON-ALCOHOLIC STEATOHEPATITIS
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批准号:nhmrc : 585411
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项目类别:NHMRC Project Grants
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资助金额:$35.58万
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财政年份:2010
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负责人:Prof Geoffrey Farrell
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依托单位:
MOLECULAR AND CELLULAR PATHOGENESIS OF HUMAN LIVER DISEASE
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批准号:nhmrc : 358398
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项目类别:Programs
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资助金额:$328.62万
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财政年份:2005
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负责人:Prof Geoffrey Farrell
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依托单位:
Preconditioning: the molecular basis for protection from hepatic ischemia-reperfusion injury
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批准号:nhmrc : 211137
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项目类别:NHMRC Project Grants
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资助金额:$27.14万
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财政年份:2002
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负责人:Prof Geoffrey Farrell
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依托单位:
ALCOHOL AND IMPAIRED LIVER REGENERATION: EFFECTS ON MITOGENIC SIGNALING PATHWAYS
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批准号:nhmrc : 107293
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项目类别:NHMRC Project Grants
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资助金额:$24.36万
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财政年份:2000
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负责人:Prof Geoffrey Farrell
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依托单位:
The mechanism of flucloxacillin hepatotoxicity
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批准号:nhmrc : 980063
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项目类别:NHMRC Project Grants
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资助金额:$11.33万
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财政年份:1998
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负责人:Prof Geoffrey Farrell
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依托单位:
Alcohol and calcium_signalling
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批准号:nhmrc : 970733
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项目类别:NHMRC Project Grants
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资助金额:$20.81万
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财政年份:1997
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负责人:Prof Geoffrey Farrell
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依托单位:
How anticancer drugs damage the liver
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批准号:nhmrc : 960917
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项目类别:NHMRC Project Grants
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资助金额:$8.63万
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财政年份:1996
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负责人:Prof Geoffrey Farrell
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依托单位:
How do drugs cause hepatitis and jaundice
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批准号:nhmrc : 940027
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项目类别:NHMRC Project Grants
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资助金额:$16.74万
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财政年份:1994
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负责人:Prof Geoffrey Farrell
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依托单位:
Liver enzymes and obstructed bile flow
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批准号:nhmrc : 920341
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项目类别:NHMRC Project Grants
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资助金额:$8.59万
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财政年份:1992
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负责人:Prof Geoffrey Farrell
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依托单位:
Alcohol and liver regeneration.
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批准号:nhmrc : 910837
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项目类别:NHMRC Project Grants
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资助金额:$7.25万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Interferon alters the enzymes which break down drugs in the liver
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批准号:nhmrc : 910805
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项目类别:NHMRC Project Grants
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资助金额:$15.63万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Understanding how anaesthetic gases can cause liver dam age in animals.
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批准号:nhmrc : 910840
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项目类别:NHMRC Project Grants
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资助金额:$9.37万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Nikon inverted microscope diaphot
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批准号:nhmrc : 911206
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项目类别:NHMRC Infrastructure Grants
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资助金额:$1.91万
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财政年份:1991
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负责人:Prof Geoffrey Farrell
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依托单位:
Changes in special enzymes for drug breakdown in cirrho sis of the liver
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批准号:nhmrc : 900764
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项目类别:NHMRC Project Grants
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资助金额:$12.48万
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财政年份:1990
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负责人:Prof Geoffrey Farrell
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依托单位:
Changes in liver blood supply and sex hormone breakdown in rats and patients
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批准号:nhmrc : 890391
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项目类别:NHMRC Project Grants
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资助金额:$5.7万
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财政年份:1989
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负责人:Prof Geoffrey Farrell
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依托单位:
Interferon blocks excretion of other drugs
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批准号:nhmrc : 880220
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项目类别:NHMRC Project Grants
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资助金额:$5.95万
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财政年份:1988
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负责人:Prof Geoffrey Farrell
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依托单位:
海外基金