Cell cycle checkpoint control in C. elegans

线虫细胞周期检查点控制

• 批准号: 10205323
• 负责人: Needhi Bhalla
• 金额: $ 38.5万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-03 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10205323
• 关键词: Address; Aneuploid Cells; Aneuploidy; Behavior; Biological; Caenorhabditis elegans; Cell Cycle; Cell Cycle Arrest; Cell Cycle Checkpoint; Cell physiology; Cells; Chromosome Segregation; Chromosome Structures; Chromosomes; Congenital Abnormality; Defect; Diagnostic; Disease; Ensure; Future; Infertility; Malignant Neoplasms; Monitor; Organism; Play; Proteins; Regulation; Role; Shapes; Spontaneous abortion; Tissues; Work; cell type; daughter cell; prevent; response

Project Summary Chromosome segregation is precisely controlled to ensure that daughter cells receive the correct number of chromosomes. Cell cycle checkpoints play an important role in this regulation by monitoring chromosome behavior and delaying or arresting the cell cycle to correct errors. Despite being characterized almost exclusively in single cells, the functions of cell cycle checkpoints are perhaps most critical in multicellular organisms, where chromosomal abnormailities can produce cancer, infertility, miscarriages and birth defects. As multicellular organisms develop, cells undergo dramatic changes in size, shape, fate, chromosome structure and cell cycle duration. How the function of cell cycle checkpoints is coordinated with and modulated by these changes in cellular context are unknown. We have shown that checkpoint proteins in one biological context can monitor and regulate radically different chromosome behaviors in a different biological context. By analyzing the function and regulation of essential checkpoint factors in cells that vary in size, shape, fate, and tissue in C. elegans, we will identify mechanisms, both common and unique, that guarantee that chromosomes segregate properly in all cell types. Fundamentally, our future work is focused on addressing two major questions: Does the function of checkpoint proteins vary depending on their biological context, such that the same proteins appear to have dramatically different roles? Or are there common fundamental mechanisms that monitor diverse chromosome behaviors to produce functionally different checkpoint responses?

项目总结