Biobehavioral Research Training in Symptom Science

项目摘要 科学的基础症状病因学，症状的经验，和症状管理， 在过去的几十年里有了很大的进步。然而，人们对生物行为的基础知之甚少， 或在症状期间生物和行为因素相互作用的方式 体验.更少的是知道症状管理策略，可以有效地针对这两个 症状反应的生物和行为成分。此外，症状发生在 影响力很大的社会因素。迫切需要确定症状的社会决定因素 表现和管理，可能有助于独特的生物行为表型和基础，许多 健康差距。本培训计划的目的是准备5名博士前护理学生和3名 博士后护士学员进行症状科学的生物行为研究。完成后 计划，学员将有必要的知识和技能：1）设计和进行生物行为 症状和健康相关结果的研究，2）采用多种方法，生物行为方法， 症状的测量和症状管理策略的测试，3）检查 社会决定因素在症状表现和症状中的中介和/或调节作用 管理，4）制定和实施症状研究方案， 经济上多样化的人群在疾病轨迹，和4）转化为研究结果， 症状预防、评估和管理的建议。博士前课程 包括在护理的UCSF学校的标准博士学位要求，4个特定的课程（理论和 症状科学的方法，研究症状的生物行为方法，基因组学和其他组学， 和社会决定因素），以及研究驻地。博士后培训生将参加4个症状- 具体的课程，并从事其他突出的选修课，以推进生物行为的研究目标， 在个性化的计划中定义。他们还将有一个研究驻地量身定制，以更多的 先进的研究目标和宏伟的目标。跨学科教师群体具有重要意义 症状科学的专业知识，生物和行为研究方法的整合，以及 健康的社会决定因素。该集团包括护理学院的16名教师和9名附属教师 从UCSF的其他学校。准备护士学者推进症状科学通过严格的 生物行为研究的研究培训对于改善对症状的理解至关重要 经验和更好地管理患者和临床医生的症状。加州大学旧金山分校护理学院 是在一个独特的地位，提供跨学科的培训，临床和转化研究，因为 其强大的研究计划，其成功的研究培训的历史，以及其正在进行的合作， 其他部门和中心在加州大学旧金山分校，参与了与健康相关的科学。

Project Summary The science underlying symptom etiology, the symptom experience, and symptom management has advanced substantially over the last few decades. Yet little is known about the biobehavioral underpinnings of many symptoms or the ways in which biological and behavioral factors interact during the symptom experience. Even less is known about symptom management strategies that can effectively target both biological and behavioral components of the symptom response. In addition, symptoms occur within a context of very influential social factors. There is an urgent need to identify social determinants of symptom presentation and management that may contribute to unique biobehavioral phenotypes and underlie many health disparities. The purpose of this training program is to prepare 5 predoctoral nursing students and 3 postdoctoral nurse trainees to conduct biobehavioral research in symptom science. Upon completion of the program, trainees will have the knowledge and skills necessary to: 1) design and conduct biobehavioral research on symptoms and health-related outcomes, 2) employ multi-method, biobehavioral approaches to the measurement of symptoms and the testing of symptom management strategies, 3) examine the mediating and/or moderating roles of social determinants in symptom presentation and symptom management, 4) develop and implement programs of symptom research with ethnically and socio- economically diverse populations across the illness trajectory, and 4) translate research findings into recommendations for symptom prevention, assessment and management. The predoctoral curriculum includes standard PhD requirements at UCSF School of Nursing, 4 symptom-specific courses (theories & methods of symptom science, biobehavioral methods for studying symptoms, genomics and other omics, and social determinants), and a research residency. Postdoctoral trainees will participate in the 4 symptom- specific courses and engage in other salient electives to advance biobehavioral research objectives that are defined in an individualized program plan. They will also have a research residency tailored to more advanced research aims and grantsmanship goals. The interdisciplinary faculty group has significant expertise in symptom science, the integration of biologic and behavioral research methodologies, and social determinants of health. The group includes 16 faculty in the School of Nursing and 9 affiliated faculty from other Schools at UCSF. Preparing nurse scholars to advance symptom science through rigorous research training in biobehavioral research is essential for improved understanding of the symptom experience and better management of symptoms by patients and clinicians. The UCSF School of Nursing is in a unique position to provide interdisciplinary training in clinical and translational research because of its strong research programs, its history of successful research training, and its ongoing collaboration with other Departments and Centers at UCSF that are involved in symptom-related science.