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Characteristics and impact of chronic pain and pain management in older adults

老年人慢性疼痛和疼痛管理的特征和影响

基本信息

批准号：
10491669
负责人：
CHRISTINE A. MIASKOWSKI
金额：
$ 36.64万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10491669
关键词：
Acetaminophen Adult Adverse effects Affect Age Age Reporting Age-Years Ageism American Anxiety Awareness Biological Biological Factors Cardiovascular system Characteristics Chronic Chronic Obstructive Pulmonary Disease Complex Data Diabetes Mellitus Effectiveness Elderly Enrollment Environment Future Goals Growth Guidelines Heart failure Intervention Investigation Knowledge Location Longitudinal Studies Medical Mental Depression Methodology Nature Non-Steroidal Anti-Inflammatory Agents Opioid Opioid Analgesics Outcome Pain Pain management Patient Outcomes Assessments Patient-Focused Outcomes Persistent pain Pharmacological Treatment Pharmacology Physical Function Policies Population Population Research Population Study Prevalence Psychological Factors Quality of life Reporting Research Sampling Severities Site Social support Special Population Stress Subgroup Surveys Testing United States chronic pain chronic pain management cognitive function comorbidity effective intervention epidemiology study experience gastrointestinal improved improved outcome multiple chronic conditions older patient opioid therapy overdose death pain score person centered population survey prescription opioid psychologic sex side effect social social factors social stigma virtual

项目摘要

Project Summary/Abstract Approximately 38.5% of Americans >65 years of age report chronic pain lasting 6 months or longer. This percentage is expected to increase given the growth in the older adult population and the associated growth of chronic conditions that can contribute to pain. Chronic pain tends to be more complex in older adults with ~70% of them describing pain in multiple sites and over 60% describing multiple types of pain. To date, no large national sample of older adults provides detailed, longtitudinal information on the experience of chronic pain in older adults; the pharmacologic and nonpharmacologic strategies that older adults are using to manage their chronic pain; and the impact of chronic pain on important person-centered outcomes. The proposed study will fill these significant gaps in knowledge by conducting the first national longitudinal study focused on chronic pain in older adults. In a large national sample of 1888 older adults, of whom 1,232 have chronic pain (i.e., pain >6 months duration) and 656 do not have chronic pain, we aim to: 1) Determine the prevalence and characteristics (i.e. quality, severity, interference) of chronic pain as well as identify the pharmacologic and non-pharmacologic treatments used to manage chronic pain; 2) Evaluate for longitudinal differences in biological, psychological, social factors, as well as physical and cognitive function and QoL between older adults with and without chronic pain; and 3) Examine the longitudinal relationships between chronic pain (i.e., worst pain score) and patient reported outcomes (i.e., physical function, cognitive function, QoL). We will determine which biological, psychological, and social factors at enrollment are associated with changes in the trajectories of chronic pain, identify subgroups of older adults with distinct pain profiles using latent profile analysis, and determine how changes in the trajectories of physical function, cognitive function, and QoL are associated with these distinct pain profile classes. Informed by a better understanding of pain characteristics, factors associated with chronic pain, treatment approaches and long-term impact, we will be equipped to develop and test tailored interventions that target subgroups of older patients, with the goal of improving the management of chronic pain, as well as overall function and QoL.

项目总结/文摘