Training in Pediatric Nonmalignant Hematology and Stem Cell Biology

儿科非恶性血液学和干细胞生物学培训

• 批准号: 10382278
• 负责人: KATHLEEN M. SAKAMOTO
• 金额: $ 23.45万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10382278
• 关键词: Childhood; Hematology; Non-Malignant; Training; stem cell biology

Project Summary/Abstract Very little is understood about the molecular pathogenesis of many hematologic diseases in children. We have developed an innovative, multidisciplinary training program in pediatric nonmalignant hematology and stem cell biology with investigators who have unique expertise and can foster multidisciplinary research. Currently, there is no other program at Stanford University that supports the training of MD, MD/PhD, or PhD fellows to study Pediatric Nonmalignant Hematology and Stem Cell Biology. Given the declining number of translational and basic scientists in this area of research, our training program is critical to continue advancements in the field and maintain a pipeline of researchers focusing on pediatric nonmalignant hematology and stem cell biology. We propose a training program that integrates a variety of disciplines and expertise, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, proteomics/genomics, translational research, and bioinformatics. In this revised renewal application, we have added new faculty with expertise in novel, cutting edge technologies; new aspects of the program in translational research in collaboration with experts in Silicon Valley including those in pharmaceutical and biotechnology industries; an expert in bioinformatics and a new bioinformatic course for trainees, and new junior faculty who will be mentored to become T32 faculty mentors in the future. In this application, we seek funding for two MD, MD/PhD, or PhD postdoctoral fellows per year for a maximum of two years. Trainees will have the opportunity to develop research in one of the 22 established faculty mentor’s laboratories. Trainees will be selected from a pool of approximately 54 eligible internal postdoctoral fellow candidates in addition to external candidates based on their academic potential, career goals, and research achievements. The second year of funding will depend on their progress reports. Trainees will participate in journal clubs, hematology and stem cell biology lectures, clinic conferences, and research seminars. Career development workshops for trainees include Grant Writing, Professionalism, and Leadership. Trainees will also be required to take a course on Pediatric Nonmalignant Hematology and Stem Cell Biology and Ethics and Scientific Integrity. Trainees will meet with the Program Directors and Scholarship Oversight Committees every 6 months to monitor progress and will present their work at national and international meetings. The External Advisory Committee will review the program and meet with trainees every year. We will utilize the strengths of Stanford University to develop research collaborations in Pediatric Nonmalignant Hematology and Stem Cell Biology, including the breadth and depth of investigators across many disciplines, to train future leaders in the field.

项目摘要/摘要 关于儿童许多血液学疾病的分子发病机理的理解很少。 我们已经开发了一项创新的多学科培训计划 具有独特专业知识并且可以培养的研究人员的血液学和干细胞生物学 多学科研究。目前，斯坦福大学没有其他课程支持 医学博士，医学博士学位或博士学位研究员的培训研究小儿非恶性血液学和干细胞生物学。 考虑到这一研究领域的转化和基础科学家数量减少，我们的培训计划是 继续在该领域的进步并保持专注于小儿的研究人员的渠道至关重要 非恶性血液学和干细胞生物学。 我们提出了一项培训计划，以整合各种学科和专业知识，包括分子 和细胞造血，替代生物模型，干细胞移植，保护性基因组学， 翻译研究和生物信息学。在此修订后的续订申请中，我们添加了新的教师 具有新颖，尖端技术方面的专业知识；该计划的新方面翻译 与硅谷专家合作的研究，包括制药和 生物技术行业；是生物信息学专家和针对学员的新生物信息学课程的专家， 将来将被指导成为T32教师导师的新初级教师。 在此申请中，我们每年为两名MD，MD/PhD或博士博士后研究员寻求资金 最多两年。学员将有机会在22个已建立的研究中进行研究 教师导师的实验室。学员将从大约54个合格的内部池中选出 博士后候选人除了基于外部候选人的学术潜力，职业 目标和研究成就。资金的第二年将取决于他们的进度报告。 学员将参加期刊俱乐部，血液学和干细胞生物学讲座，诊所会议以及 研究中心。学员的职业发展研讨会包括赠款写作，专业精神和 领导。还将要求学员参加有关小儿非恶性血液学和STEM的课程 细胞生物学和伦理学和科学完整性。学员将与计划董事和奖学金会面 监督委员会每6个月监控进度，并将在国家和 国际会议。外部咨询委员会将审查该计划并与培训会面 每年。我们将利用斯坦福大学的优势来开发小儿的研究合作 非恶性血液学和干细胞生物学，包括研究人员的广度和深度 许多学科，以培训该领域的未来领导人。

项目成果

Microbiota modification in hematology: still at the bench or ready for the bedside?

• DOI: 10.1182/bloodadvances.2019000365
• 发表时间: 2019-11
• 期刊: Blood advances
• 影响因子: 7.5
• 作者: C. Severyn;R. Brewster;T. Andermann

Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.

• DOI: 10.1016/j.ymgme.2017.07.008
• 发表时间: 2017-11
• 期刊: Molecular genetics and metabolism
• 影响因子: 3.8
• 作者: Wilkes MC;Repellin CE;Sakamoto KM
• 通讯作者: Sakamoto KM

Harnessing Mechanisms of Immune Tolerance to Improve Outcomes in Solid Organ Transplantation: A Review.

• DOI: 10.3389/fimmu.2021.688460
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Slepicka PF;Yazdanifar M;Bertaina A
• 通讯作者: Bertaina A

Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a.

• DOI: 10.1016/j.exphem.2020.09.187
• 发表时间: 2020-11
• 期刊: Experimental hematology
• 影响因子: 2.6
• 作者: Wilkes MC;Siva K;Varetti G;Mercado J;Wentworth EP;Perez CA;Saxena M;Kam S;Kapur S;Chen J;Narla A;Glader B;Lin S;Serrano M;Flygare J;Sakamoto KM
• 通讯作者: Sakamoto KM

Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites.

• DOI: 10.7554/elife.61516
• 发表时间: 2021-05-24
• 期刊: eLife
• 影响因子: 7.7
• 作者: Shakya B;Patel SD;Tani Y;Egan ES
• 通讯作者: Egan ES