Training in Pediatric Nonmalignant Hematology and Stem Cell Biology

儿科非恶性血液学和干细胞生物学培训

• 批准号: 10382278
• 负责人: KATHLEEN M. SAKAMOTO
• 金额: $ 23.45万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10382278
• 关键词: Childhood; Hematology; Non-Malignant; Training; stem cell biology

Project Summary/Abstract Very little is understood about the molecular pathogenesis of many hematologic diseases in children. We have developed an innovative, multidisciplinary training program in pediatric nonmalignant hematology and stem cell biology with investigators who have unique expertise and can foster multidisciplinary research. Currently, there is no other program at Stanford University that supports the training of MD, MD/PhD, or PhD fellows to study Pediatric Nonmalignant Hematology and Stem Cell Biology. Given the declining number of translational and basic scientists in this area of research, our training program is critical to continue advancements in the field and maintain a pipeline of researchers focusing on pediatric nonmalignant hematology and stem cell biology. We propose a training program that integrates a variety of disciplines and expertise, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, proteomics/genomics, translational research, and bioinformatics. In this revised renewal application, we have added new faculty with expertise in novel, cutting edge technologies; new aspects of the program in translational research in collaboration with experts in Silicon Valley including those in pharmaceutical and biotechnology industries; an expert in bioinformatics and a new bioinformatic course for trainees, and new junior faculty who will be mentored to become T32 faculty mentors in the future. In this application, we seek funding for two MD, MD/PhD, or PhD postdoctoral fellows per year for a maximum of two years. Trainees will have the opportunity to develop research in one of the 22 established faculty mentor’s laboratories. Trainees will be selected from a pool of approximately 54 eligible internal postdoctoral fellow candidates in addition to external candidates based on their academic potential, career goals, and research achievements. The second year of funding will depend on their progress reports. Trainees will participate in journal clubs, hematology and stem cell biology lectures, clinic conferences, and research seminars. Career development workshops for trainees include Grant Writing, Professionalism, and Leadership. Trainees will also be required to take a course on Pediatric Nonmalignant Hematology and Stem Cell Biology and Ethics and Scientific Integrity. Trainees will meet with the Program Directors and Scholarship Oversight Committees every 6 months to monitor progress and will present their work at national and international meetings. The External Advisory Committee will review the program and meet with trainees every year. We will utilize the strengths of Stanford University to develop research collaborations in Pediatric Nonmalignant Hematology and Stem Cell Biology, including the breadth and depth of investigators across many disciplines, to train future leaders in the field.

项目总结/文摘

项目成果

Microbiota modification in hematology: still at the bench or ready for the bedside?

• DOI: 10.1182/bloodadvances.2019000365
• 发表时间: 2019-11
• 期刊: Blood advances
• 影响因子: 7.5
• 作者: C. Severyn;R. Brewster;T. Andermann

Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.

• DOI: 10.1016/j.ymgme.2017.07.008
• 发表时间: 2017-11
• 期刊: Molecular genetics and metabolism
• 影响因子: 3.8
• 作者: Wilkes MC;Repellin CE;Sakamoto KM
• 通讯作者: Sakamoto KM

Harnessing Mechanisms of Immune Tolerance to Improve Outcomes in Solid Organ Transplantation: A Review.

• DOI: 10.3389/fimmu.2021.688460
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Slepicka PF;Yazdanifar M;Bertaina A
• 通讯作者: Bertaina A

Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites.

• DOI: 10.7554/elife.61516
• 发表时间: 2021-05-24
• 期刊: eLife
• 影响因子: 7.7
• 作者: Shakya B;Patel SD;Tani Y;Egan ES
• 通讯作者: Egan ES

Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a.

• DOI: 10.1016/j.exphem.2020.09.187
• 发表时间: 2020-11
• 期刊: Experimental hematology
• 影响因子: 2.6
• 作者: Wilkes MC;Siva K;Varetti G;Mercado J;Wentworth EP;Perez CA;Saxena M;Kam S;Kapur S;Chen J;Narla A;Glader B;Lin S;Serrano M;Flygare J;Sakamoto KM
• 通讯作者: Sakamoto KM