Palliative Care Research Cooperative Group (PCRC): Data, Informatics and Statistics Core

项目摘要/摘要 U2C应用程序的主要目标是提高姑息治疗的生产力和影响 研究合作小组(PCRC)通过促进高质量、有效的临床研究的进行 以及在进行多地点临床试验方面扩大姑息治疗研究人员的数量和专业知识。在……里面 追求这些总的目标和目的，数据、信息学和统计核心(DISC)，四个之一 PCRC内部的核心，努力成为设计多站点统计分析计划的资源 临床试验，并向大多数多地点提供定量和/或定性生物统计学支持 使用PCRC资源的临床试验和数据分析项目。光盘的具体目标是：(1)促进 协作性、严谨、多站点、EOLPC研究，通过提供与设计和 分析从形成阶段到临床试验的所有研究阶段；(2)扩展PCRC数据 存储库，来自PCRC资助和支持的研究的定性和定量数据的仓库 和其他EOLPC研究，以促进二次数据分析；(3)与其他 PCRC核心(测量；护理研究；临床研究/方法学)和中心 实现PCRC的总体具体目标以及核心和中心的具体目标；以及(4)与 调查人员发展中心(IDC)在统计方法方面对PCRC调查人员进行教育和指导 和书房设计。如果没有坚实的统计学基础，严格的姑息治疗研究是不可能存在的。这个 裁谈会承担着一系列不同的任务，既有针对核心任务的专题，也有相互关联的任务 并与其他PCRC中心和核心集成。光盘起到了扩大产能的催化剂的作用 为了更好地量化和了解严重疾病和治疗对健康的影响， 通过严格的研究设计、实施和护理，患者和照顾者的生活质量和临终轨迹 数据捕获/分析。

PROJECT SUMMARY/ABSTRACT The primary goals of the U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC) through facilitating the conduct of high-quality, effective clinical research and expanding the number and expertise of palliative care researchers in conducting multi-site clinical trials. In pursuit of these overall goals and objectives, the Data, Informatics and Statistics Core (DISC), one of four Cores within the PCRC, strives to serve as a resource for the design of statistical analysis plans for multi-site clinical trials and to provide quantitative and/or qualitative biostatistical support to the majority of multi-site clinical trials and data-analysis projects using PCRC resources. The DISC's specific aims are: (1) to facilitate collaborative, rigorous, multi-site, EOLPC research studies by providing resources pertinent to the design and analysis of all stages of research ranging from formative to clinical trials; (2) to expand the PCRC Data Repository, a warehouse of both qualitative and quantitative data from PCRC funded and supported studies and other EOLPC research studies, to facilitate secondary data analyses; (3) to collaborate with the other PCRC Cores (Measurement; Caregiver Research; and Clinical Studies/Methodology) and Centers to accomplish the overall Specific Aims of the PCRC and the Core and Center specific aims; and (4) to work with the Investigator Development Center (IDC) to educate and mentor PCRC investigators in statistical methods and study design. Rigorous palliative care research cannot exist without a solid statistical foundation. The DISC undertakes diverse set of tasks that are both topically-specific to the mission of the Core and interrelate and integrate with the other PCRC Centers and Cores. The DISC serves as a catalyst to expand the capacity of the PCRC to better quantify and understand the impact of serious illness and treatments on the health, quality of life, and end-of-life trajectory of patients and caregivers through rigorous study design, conduct and data capture/analysis.