Adaptive visual representation in human posterior parietal cortex

项目总结 人类认知的核心是自适应地与我们的视觉互动的能力 通过收集和积累相关信息来指导思想和 行为。最近的研究已经明确了顶叶后皮质的重要作用 (PPC)支持自适应视觉处理。基于最近关于 PPC和两组令人兴奋的关于人类PPC视觉表征的初步发现 涉及注意力和视觉工作记忆(VWM)，本提案旨在 以同样的严谨和精度记录PPC中视觉处理的性质 用于研究OTC中的视觉表征的那些。这里最重要的假设是 与任务相关的因素在形成视觉表征方面起着更突出的作用 PPC而不是OTC，以及理解OTC中视觉表示的复杂细节的关键 PPC是通过它与任务相关因素的互动来实现的。使用fMRI模式解码 和对文档PPC表征结构的表征相似度分析 人类，本提案考察了自适应视觉的两个基本方面 加工：注意和任务对适应性视觉表征的贡献 目标1中的PPC，以及目标2中PPC中VWM表示的性质。理解 总的来说，使用体素重叠分析的PPC视觉处理的神经基础 研究建议，我们将检查相同或不同的PPC神经元 种群对PPC视觉处理的不同方面有贡献。建议数 研究将首次深入和系统地了解 人脑PPC视觉表征的本质及其与重要信息的相互作用 与任务相关的因素。他们应提供关于适应程度的基础知识 视觉处理是在人脑中完成的。

PROJECT SUMMARY Central to human cognition is the ability to interact adaptively with our visual environment by collecting and accumulating pertinent information to guide thoughts and behavior. Recent work has pinpointed the significant role of posterior parietal cortex (PPC) in supporting adaptive visual processing. Building upon two recent reviews on PPC and two sets of exciting preliminary findings on visual representation in human PPC involving attention and visual working memory (VWM), the present proposal aims to document the nature of visual processing in PPC with the same rigor and precision as those used to study visual representation in OTC. The overarching hypothesis here is that task-related factors play a more prominent role in shaping visual representation in PPC than OTC and the key to understand the intricate details of visual representation in PPC is through its interactions with task-related factors. Using fMRI pattern decoding and representational similarity analyses to document PPC representational structure in humans, the present proposal examines two fundamental aspects of adaptive visual processing: The contributions of attention and task to adaptive visual representation in PPC in Aim 1, and the nature of VWM representation in PPC in Aim 2. To understand the neural underpinnings of PPC visual processing, using voxel overlap analysis, in all the studies proposed, we will examine whether the same or distinct PPC neuronal populations contribute to different aspect of PPC visual processing. The proposed studies will provide for the first time an in-depth and systematic understanding of the nature of PPC visual representation in the human brain and its interaction with important task-related factors. They shall provide foundational knowledge regarding how adaptive visual processing is accomplished in the human brain.