Adaptive visual representation in human posterior parietal cortex

项目摘要 人类认知的核心是与我们的视觉适应性互动的能力。 通过收集和积累相关信息来指导思想和环境， 行为最近的研究已经明确了后顶叶皮层在大脑中的重要作用 (PPC)支持自适应视觉处理。在最近两次审查 PPC和两组关于人类PPC视觉表征的令人兴奋的初步发现 涉及注意力和视觉工作记忆（VWM），本提案旨在 记录PPC中视觉处理的性质，其严谨性和精度与 那些用于研究OTC中的视觉表征的人。这里最重要的假设是 与任务相关的因素在塑造视觉表征方面发挥着更突出的作用， PPC比OTC和理解的视觉表示中的错综复杂的细节的关键 PPC是通过与任务相关因素的相互作用而产生的。使用功能磁共振成像模式解码 和代表性相似性分析，以记录PPC代表性结构， 人类，目前的建议审查两个基本方面的适应性视觉 加工：注意力和任务对适应性视觉表征的贡献， 目标1中的PPC，以及目标2中PPC中VWM表示的性质。了解 PPC视觉处理的神经基础，使用体素重叠分析，在所有 在这项研究中，我们将研究是否相同或不同的PPC神经元， 不同的人群对PPC视觉处理的不同方面做出了贡献。拟议 研究将首次提供一个深入和系统的了解， PPC视觉表征在人脑中的性质及其与重要的 任务相关因素。他们将提供关于如何适应 视觉处理在人脑中完成。

PROJECT SUMMARY Central to human cognition is the ability to interact adaptively with our visual environment by collecting and accumulating pertinent information to guide thoughts and behavior. Recent work has pinpointed the significant role of posterior parietal cortex (PPC) in supporting adaptive visual processing. Building upon two recent reviews on PPC and two sets of exciting preliminary findings on visual representation in human PPC involving attention and visual working memory (VWM), the present proposal aims to document the nature of visual processing in PPC with the same rigor and precision as those used to study visual representation in OTC. The overarching hypothesis here is that task-related factors play a more prominent role in shaping visual representation in PPC than OTC and the key to understand the intricate details of visual representation in PPC is through its interactions with task-related factors. Using fMRI pattern decoding and representational similarity analyses to document PPC representational structure in humans, the present proposal examines two fundamental aspects of adaptive visual processing: The contributions of attention and task to adaptive visual representation in PPC in Aim 1, and the nature of VWM representation in PPC in Aim 2. To understand the neural underpinnings of PPC visual processing, using voxel overlap analysis, in all the studies proposed, we will examine whether the same or distinct PPC neuronal populations contribute to different aspect of PPC visual processing. The proposed studies will provide for the first time an in-depth and systematic understanding of the nature of PPC visual representation in the human brain and its interaction with important task-related factors. They shall provide foundational knowledge regarding how adaptive visual processing is accomplished in the human brain.