Phenotyping and Environmental Modifier Facility Core

项目摘要 我们的表型和环境改进剂设备核心(PEMFC)组织了西奈山广泛的 作为关键中心的现有环境流行病学、临床、心理测量、分析和技术专业知识 资源。在前三年，质子交换膜燃料电池帮助促进了环境健康研究的显著增长 多年来，我们的中心将环境暴露及其修改剂与健康和 发展。PEMFC使中心成员能够接触到专业知识和最先进的设备 对健康和发育结果的临床表型和量化是必要的 寿命以及化学环境毒素修饰剂的测量。 质子交换膜燃料电池提供了 临床、技术和科学投入，以加强选择适合年龄的有效、可靠和适时的 有效的低负担测量仪器 生命周期中的健康和疾病，特别关注 关键时期(孕期、婴儿期、幼儿期、青春期) 。这包括中心支持的空间和 涵盖迄今确定的目标优先领域的表型设备(神经发育/行为、肥胖、 哮喘、过敏、内分泌、肾脏和心血管表型)。 核心还促进了翻译 研究旨在更充分地阐明化学毒物和 影响发展的环境因素，特别是心理压力和其他社会决定因素 以及营养。考虑到接触化学和非化学毒物以及营养状况 通常沿着社会经济梯度一起追踪，相关的焦点将是对 在我们当地社区和全球范围内观察到的健康差距背后的机制。这个 PEMFC的责任范围包括：1)维护和提供成人和儿童的接触 健康评估，包括自我报告、观察数据和基于绩效的衡量标准；2) 协助中心成员在实施此类措施时使用严格和适当的方案 研究研究；3)就数据分析提供咨询，包括心理测量分析，包括使用 表型或真正的多变量分析中的多种表型；以及5)将环境健康与 西奈山的精准医疗计划。 PEMFC负责策划由我们的专家教职员工确定的措施 以及实施措施所需的信息，包括心理测量学摘要 以及详细的数据收集、评分程序和纳入分析的方案(S)。质子交换膜燃料电池 教师有专门的专业知识来指导选择下列措施 可以通过公共的 标准化度量 为了方便 数据共享、互操作性和协调性以催化 为中心成员提供参与协作多站点研究的机会。PEMFC的教职员工也将工作 与我们的临床同事一起将环境健康数据与电子健康记录数据集成在一起，以催化 西奈山卫生系统的环境卫生转化研究。

Project Summary Our Phenotyping and Environmental Modifier Facility Core (PEMFC) organizes Mount Sinai's extensive existing environmental epidemiology, clinical, psychometric, analytic and technical expertise as a key Center resource. The PEMFC helped catalyze the remarkable growth in environmental health research over the first 3 years of our Center linking environmental exposure and their modifiers to measures of health and development. The PEMFC provides Center Members access to expertise and state-of-the-art equipment necessary for clinical phenotyping and quantification of health and developmental outcomes across the lifespan as well as the measurement of modifiers of chemical environmental toxins. The PEMFC provides clinical, technical and scientific input to enhance the selection of age-appropriate valid, reliable and time effective low burden instruments to measure health and disease across the lifespan with particular focus on critical periods (pregnancy, infancy, early childhood, adolescence) . This includes Center supported space and phenotyping equipment covering target priority areas identified to date (neurodevelopment/behavior, obesity, asthma, allergy, endocrine, renal and cardiovascular phenotypes). The Core also facilitates translational research aimed toward more fully elucidating the impacts of key interactions between chemical toxicants and environmental modifiers across development, specifically psychological stress and other social determinants as well as nutrition. Given that exposure to chemical and non-chemical toxicants as well as nutritional status often track together along socioeconomic gradients, a related focus will be the multi-faceted elucidation of mechanisms underlying the health disparities observed in our local communities and more globally. The scope of responsibility for the PEMFC includes: 1) maintaining and providing access to adult and pediatric health assessments that include self-reports, observational data, and performance based measures; 2) assisting Center Members with rigorous and appropriate protocols to use when applying such measures in research studies; 3) advising on data analysis that includes psychometric analyses including the use of multiple phenotypes in a phenomic or true multivariate analysis; and 5) integrating environmental health with precision medicine initiatives at Mount Sinai. The PEMFC curates measures identified by our expert faculty together with the information needed to implement the measures including a summary of the psychometrics and detailed protocol(s) for data collection, scoring procedures, and incorporation into analyses. PEMFC faculty have particular expertise to guide selection of measures that can be characterized through a common standardized metric in order to facilitate data sharing, interoperability and harmonization to catalyze opportunities for Center Members to participate in collaborative multi-site studies. PEMFC faculty will also work with our clinical colleagues to integrate environmental health data with electronic health record data to catalyze environmental health translational research across the Mount Sinai Health System.