Phenotyping and Environmental Modifier Facility Core

表型分析和环境修饰设施核心

• 批准号: 10388188
• 负责人: Rosalind J Wright
• 金额: $ 20.25万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-18 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388188
• 关键词: Address; Adolescence; Adult; Age; Archives; Area; Behavior; Bioinformatics; Biological Markers; Biometry; Cardiometabolic Disease; Cardiovascular system; Chemical Modifier; Chemicals; Child; Childhood; Clinical; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communities; Consultations; Core Facility; Data; Data Analyses; Data Collection; Development; Disease; Educational workshop; Electronic Health Record; Endocrine; Endocrine System Diseases; Ensure; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Risk Factor; Equilibrium; Equipment; Exposure to; Faculty; Funding; Growth; Health; Health Sciences; Health Status; Health system; Hydrocortisone; Hypersensitivity; Immunophenotyping; Integration Host Factors; Intervention; Kidney; Kidney Diseases; Laboratories; Libraries; Life Cycle Stages; Link; Longevity; Measurement; Measures; Mediating; Mediation; Methodology; Methods; Mission; Modeling; Multivariate Analysis; National Institute of Environmental Health Sciences; Nutrition Assessment; Nutritional; Nutritional status; Obesity; Online Systems; Outcome; Oxidative Stress; Pathway interactions; Patient Self-Report; Phenotype; Physiological; Plasma; Population; Precision Medicine Initiative; Pregnancy; Procedures; Protocols documentation; Psychological Stress; Psychometrics; Psychosocial Stress; Research; Research Support; Resources; Risk; Salivary; Science; Services; Site; Societies; Standardization; Stress; Surveys; Technical Expertise; Time; Toxic Environmental Substances; Toxicant exposure; Training; Translational Research; Work; adipokines; base; built environment; clinical phenotype; contextual factors; critical period; data sharing; early childhood; health assessment; health data; health disparity; hypothalamic-pituitary-adrenal axis; immunoregulation; infancy; instrument; interoperability; meetings; member; neurodevelopment; nutrition; obesity-associated asthma; performance based measurement; phenomics; phenotypic data; pre-clinical; ranpirnase; research study; respiratory; response; sample collection; social determinants; social health determinants; socioeconomics; tool; toxicant; web portal

Project Summary Our Phenotyping and Environmental Modifier Facility Core (PEMFC) organizes Mount Sinai's extensive existing environmental epidemiology, clinical, psychometric, analytic and technical expertise as a key Center resource. The PEMFC helped catalyze the remarkable growth in environmental health research over the first 3 years of our Center linking environmental exposure and their modifiers to measures of health and development. The PEMFC provides Center Members access to expertise and state-of-the-art equipment necessary for clinical phenotyping and quantification of health and developmental outcomes across the lifespan as well as the measurement of modifiers of chemical environmental toxins. The PEMFC provides clinical, technical and scientific input to enhance the selection of age-appropriate valid, reliable and time effective low burden instruments to measure health and disease across the lifespan with particular focus on critical periods (pregnancy, infancy, early childhood, adolescence) . This includes Center supported space and phenotyping equipment covering target priority areas identified to date (neurodevelopment/behavior, obesity, asthma, allergy, endocrine, renal and cardiovascular phenotypes). The Core also facilitates translational research aimed toward more fully elucidating the impacts of key interactions between chemical toxicants and environmental modifiers across development, specifically psychological stress and other social determinants as well as nutrition. Given that exposure to chemical and non-chemical toxicants as well as nutritional status often track together along socioeconomic gradients, a related focus will be the multi-faceted elucidation of mechanisms underlying the health disparities observed in our local communities and more globally. The scope of responsibility for the PEMFC includes: 1) maintaining and providing access to adult and pediatric health assessments that include self-reports, observational data, and performance based measures; 2) assisting Center Members with rigorous and appropriate protocols to use when applying such measures in research studies; 3) advising on data analysis that includes psychometric analyses including the use of multiple phenotypes in a phenomic or true multivariate analysis; and 5) integrating environmental health with precision medicine initiatives at Mount Sinai. The PEMFC curates measures identified by our expert faculty together with the information needed to implement the measures including a summary of the psychometrics and detailed protocol(s) for data collection, scoring procedures, and incorporation into analyses. PEMFC faculty have particular expertise to guide selection of measures that can be characterized through a common standardized metric in order to facilitate data sharing, interoperability and harmonization to catalyze opportunities for Center Members to participate in collaborative multi-site studies. PEMFC faculty will also work with our clinical colleagues to integrate environmental health data with electronic health record data to catalyze environmental health translational research across the Mount Sinai Health System.

项目概要 我们的表型和环境改性剂设施核心 (PEMFC) 组织了西奈山的广泛研究 现有环境流行病学、临床、心理测量、分析和技术专业知识作为关键中心 资源。 PEMFC 帮助促进了前 3 年环境健康研究的显着增长 我们中心多年来将环境暴露及其调节因素与健康和健康措施联系起来 发展。 PEMFC 为中心成员提供专业知识和最先进的设备 对于临床表型分析以及整个健康和发育结果的量化是必要的 寿命以及化学环境毒素调节剂的测量。 PEMFC 提供 临床、技术和科学的投入，以增​​强选择适合年龄的有效、可靠和及时性 有效的低负担衡量工具 整个生命周期的健康和疾病，特别关注 关键时期（怀孕、婴儿期、幼儿期、青春期） 。这包括中心支持的空间和 表型设备涵盖迄今为止确定的目标优先领域（神经发育/行为、肥胖、 哮喘、过敏、内分泌、肾脏和心血管表型）。 核心还促进翻译 研究旨在更全面地阐明化学毒物和化学物质之间关键相互作用的影响 发展过程中的环境因素，特别是心理压力和其他社会决定因素 还有营养。鉴于接触化学和非化学毒物以及营养状况 通常沿着社会经济梯度一起追踪，一个相关的焦点将是对 我们当地社区乃至全球范围内观察到的健康差异背后的机制。这 PEMFC 的职责范围包括： 1) 维护并提供成人和儿童的访问权限 健康评估，包括自我报告、观察数据和基于绩效的衡量标准； 2） 协助中心成员在应用此类措施时使用严格且适当的协议 研究； 3) 就数据分析提供建议，包括心理测量分析，包括使用 表型或真正的多变量分析中的多种表型； 5）将环境健康与 西奈山的精准医学倡议。 PEMFC 制定了由我们的专家团队确定的措施 以及实施措施所需的信息，包括心理测量学摘要 以及数据收集、评分程序和纳入分析的详细协议。质子交换膜燃料电池 教师拥有特殊的专业知识来指导措施的选择 可以通过一个共同的特征 标准化度量 为了方便 数据共享、互操作性和协调性，以促进 为中心成员提供参与多地点协作研究的机会。 PEMFC 教员也将工作 与我们的临床同事合作，将环境健康数据与电子健康记录数据相结合，以促进 整个西奈山卫生系统的环境健康转化研究。