Scholars in Environmental Pediatrics, Reproductive Health, and Life Course Science

环境儿科、生殖健康和生命过程科学学者

• 批准号: 10532722
• 负责人: Rosalind J Wright
• 金额: $ 48.16万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2026-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10532722
• 关键词: Address; Caring; Child; Child Health; Childhood; Chronic Disease; Clinical; Country; Development; Discipline; Disease; Ecosystem; Environment; Environmental Health; Environmental Science; Fellowship Program; Genetic; Health; Health Professional; Healthcare; Human; Individual; Infrastructure; Institution; Investments; Lead; Learning; Life; Life Cycle Stages; Medical; Mentored Clinical Scientist Development Program; Methods; Molecular; Outcome; Pediatrics; Perinatal; Physicians; Physiological; Precision Medicine Initiative; Reproductive Health; Research; Role; Running; Scholars Program; Science; Scientist; Shapes; System; Toxin; Training; Translating; Translations; Vision; Workforce Development; clinical center; disorder prevention; disorder risk; early childhood; fetal; medical specialties; microbial; next generation; novel strategies; precision medicine; programs; reproductive; research and development; social; workforce needs

The need to develop children's environmental health (CEH) clinician-scientists focused on the translation of pediatric and reproductive environmental health is critical. In parallel to the rise of developmental origins of health and disease (DOHaD) principles, precision medicine (PM) has emerged as the new approach in healthcare. PM seeks to transform medical care and disease prevention by identifying factors that more reliably predict individual risk for disease but has focused almost solely on genetics, even though environment is clearly a very large piece of the puzzle. With DOHaD principles suggesting that early life environment is at the root of most chronic diseases, a life course perspective to PM and pediatrics is needed to understand how human health is shaped by fetal and early childhood environments. Adverse health outcomes result from a multitude of environmental, social and microbial toxin-induced shifts in molecular, cellular, and physiological states and their interacting systems. Elucidating and translating the role of environment in health and development requires specific expert training. Mount training Institute (PEHSU) ecosystem Sinai has long been at the forefront of CEH clinical through the longest running pediatric environmental health fellowship program in the country, an for Exposomic Research, a P30 Core Center, a Pediatric Environmental Health Specialty Unit and a state run CEH clinical center. We are uniquely poised to leverage this well-established to continue to build national capacity in translational CEH through this exciting K12 program.Our program strives to advance a systematic plan to integrate environmental health into reproductive and pediatric PM initiatives to better address the root causes of disease. Many things are needed to realize this vision, but one of the most pressing is building the pediatric/perinatal translational workforce needed to lead this paradigm shift. Translation to better health outcomes will require developing broadly trained child health practitioners able to engage in transdisciplinary (TD) teams that extend beyond discipline-specific concepts, approaches, and methods. We seek to establish the Mount Sinai program for Scholars in Environmental Pediatrics, Reproductive Health, and Life Course Science embedded in a mature TD team science learning culture grounded in the principle that the major proportion of the variability in health outcomes is environmentally driven. This program will be led by environmental health physician-scientists and leverages Mount Sinai's longstanding commitment to CEH, our Region 2 PEHSU, our NY state children's environmental health centers, our established pipeline programs and regional networks to identify potential scholars, our infrastructure in pediatric/perinatal environmental health research and workforce development, and our institutional investments in exposomics. Our K12 program will develop healthcare professionals poised to integrate environmental science with established PM and pediatric care efforts and develop the next generation of versatile children's environmental health leaders.

需要发展儿童环境健康(CEH)临床医生-科学家专注于翻译 儿科和生殖环境健康至关重要。与发展起源的兴起并行的是 健康与疾病(DOHAD)原则，精准医学(PM)已成为 医疗保健。PM寻求通过确定更多因素来改变医疗保健和疾病预防 可靠地预测个人患疾病的风险，但几乎只关注遗传学，即使环境 显然是拼图中的一大块。根据国防部的原则，早期的生活环境处于 大多数慢性疾病的根源，需要从生命过程的角度来看待PM和儿科，以了解如何 人类健康是由胎儿和儿童早期环境决定的。不良的健康后果是由 多种环境、社会和微生物毒素引起的分子、细胞和生理变化 国家及其相互作用的系统。阐明和翻译环境在健康和环境中的作用 发展需要专门的专家培训。装载 培训 研究所 (PEHSU) 生态系 长期以来，西奈半岛一直处于CEH临床的前沿 通过全国运行时间最长的儿科环境健康奖学金计划， 对于暴露研究，P30核心中心，儿科环境卫生专科单位 和一家国营CEH临床中心。我们独一无二地准备利用这一成熟的 通过这一激动人心的K12计划，继续建设翻译CEH方面的国家能力。我们 该计划努力推进将环境健康纳入生殖和儿科的系统计划 PM倡议，以更好地解决疾病的根本原因。要实现这一愿景需要很多东西，但 最紧迫的问题之一是建立一支领导这一范例所需的儿科/围产期翻译队伍 换档。要实现更好的健康结果，就需要培养训练有素的儿童健康从业者 能够参与跨学科(TD)团队，超越学科特定的概念、方法、 和方法。我们寻求建立西奈山环境儿科学者项目， 生殖健康和生命课程科学嵌入成熟的TD团队科学学习文化 基于这样的原则，即健康结果的主要变异性是环境因素 干劲十足。该项目将由环境健康内科医生兼科学家领导，并利用西奈山的 长期致力于CEH，我们的地区2 PEHSU，我们的纽约州儿童环境健康中心， 我们已建立的管道计划和区域网络来确定潜在的学者，我们在 儿科/围产期环境健康研究和劳动力发展，以及我们的机构 对暴露组学的投资。我们的K12计划将培养准备融入 具有成熟的PM和儿科护理努力的环境科学，并开发下一代 多才多艺的儿童环境健康领袖。