Utah Population Database (UPDB)

犹他州人口数据库 (UPDB)

• 批准号: 10388119
• 负责人: NICOLA J. CAMP
• 金额: $ 53.6万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-09 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10388119
• 关键词: APC gene; Address; Area; BRCA1 gene; Behavior; Behavioral Research; Biomedical Research; Cancer Center; Cancer Center Support Grant; Cancer Etiology; Cancer Family; Cancer Patient; Cancer-Predisposing Gene; Catchment Area; Censuses; Clinic; Clinical Investigator; Clinical Trials; Collaborations; Community Outreach; Complex; Computerized Medical Record; Creativeness; DNA Sequence Alteration; Data; Data Analyses; Data Analytics; Data Set; Data Sources; Databases; Discipline; Disease; Doctor of Philosophy; Emergency department visit; Ensure; Epidemiology; Evaluation; Exposure to; Faculty; Familial Adenomatous Polyposis Syndrome; Family; Family Study; Family history of; Funding; Genealogy; Generations; Genes; Genetic; Geography; Grant; Guidelines; Health; Health Services Research; Healthcare; High-Risk Cancer; Human; Incidence; Individual; Information Services; Infrastructure; Institutes; Institutional Review Boards; Investigation; Link; Malignant Neoplasms; Manuscripts; Maps; Medical; Medical Records; Medicare; Mission; Molecular Genetics; NCI Center for Cancer Research; National Cancer Institute; Oncogenes; Outcome Study; Pattern; Peer Review; Population; Population Analysis; Population Database; Population Study; Preparation; Prevention; Preventive; Privacy; Productivity; Protocols documentation; Public Health; Publications; Quality Control; Records; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Assessment; SEER Program; Science; Secure; Services; Source; Techniques; Translations; United States; Universities; Utah; Work; Writing; advanced analytics; analytical tool; anticancer research; base; behavioral health; cancer care; community engagement; complex data; cost; cost effective; data quality; data resource; data tools; data warehouse; design; epidemiology study; gene discovery; genetic linkage; genetic pedigree; genetic testing; human disease; improved; kindred; malignant breast neoplasm; member; neoplasm registry; novel; racial diversity; recruit

UTAH POPULATION DATABASE SHARED RESOURCE ABSTRACT The Utah Population Database Shared Resource (UPDB), established at Huntsman Cancer Institute (HCI) in 1994, contributes to HCI’s mission by providing state-of-the-art data and analytic services to support genetic, epidemiologic, demographic, public health, behavioral, and health services research. UPDB provides privacy- protected access to unique data sets derived from one of the world’s richest sources of linked individual-level genealogical, medical, vital, and geospatial information, enabling diverse biomedical investigations, including statewide population analyses. The data include over 11 million individuals linked into pedigrees covering up to 17 generations. UPDB’s aims are 1) to assemble state-of-the-art integrated genealogical, medical, and vital records and provide data analysis and interpretation for cancer investigations; and 2) to support the scientific research objectives of the Cancer Center by providing access to tailored complex data sets and advanced analytic tools. UPDB has been directed by Ken Smith, PhD, since 2010. Management of UPDB within the Cancer Center ensures that this Resource addresses the needs of Cancer Center members. The services provided by UPDB are unique and do not exist at any other National Cancer Institute cancer center. UPDB adds value to cancer research by: 1) providing data and analytic tools to identify high-risk cancer families, 2) adding extensive geospatial information that permits linkages to environmental variables, and 3) offering guidelines for the efficient and cost-effective recruitment of subjects into research projects. UPDB infrastructure enables Cancer Center members to exploit otherwise unavailable key data resources, including the University of Utah Health and Intermountain Healthcare data warehouses. Cancer Center members with peer-reviewed funding comprise 11% of the users, and total cancer-related usage exceeds 48%. Since 2014, UPDB data have been used in 61 cancer-focused, Institutional Review Board (IRB)-approved projects that have yielded 118 publications. UPDB is an unparalleled biomedical research resource. It provides outstanding data quality on large multi- generational pedigrees, linked to the Surveillance, Epidemiology, and End Results (SEER) Utah Cancer Registry and most of the state’s electronic medical records. The data in UPDB span decades and are enhanced by other high-quality databases and geocodes, exposed to rigorous data quality control techniques, and made available to Cancer Center members with IRB-approved protocols at a reasonable cost. UPDB enhances the productivity and creativity of HCI’s members and contributes to the Cancer Center’s overall mission to understand the causes of cancer and promote its prevention within HCI’s catchment area, the State of Utah.

犹他州人口数据库共享资源 摘要 犹他州人口数据库共享资源（populationdatabasesharedresource，简称CQB），建立于2004年， 1994年，通过提供最先进的数据和分析服务，支持基因， 流行病学、人口统计学、公共卫生、行为学和卫生服务研究。BARB提供隐私- 受保护地访问来自世界上最丰富的个人层面关联数据源之一的独特数据集， 家谱、医学、生命和地理空间信息，使各种生物医学调查成为可能，包括 全国人口分析。这些数据包括超过1100万个与谱系相关的个体， 17代。CNOB的目标是：1）汇集最先进的综合家谱，医学和生命科学。 记录并为癌症调查提供数据分析和解释;以及2）支持科学 癌症中心的研究目标，提供访问量身定制的复杂数据集和先进的 分析工具。自2010年以来，KEB一直由Ken Smith博士执导。在联合国系统内管理联合国开发计划署 癌症中心确保此资源满足癌症中心成员的需求。的服务 由美国国家癌症研究所B提供的是独一无二的，在任何其他国家癌症研究所癌症中心都不存在。 CIBB通过以下方式为癌症研究增加价值：1）提供数据和分析工具，以识别高风险癌症 家庭，2）增加广泛的地理空间信息，允许与环境变量的联系，以及3） 为有效和具有成本效益地招募受试者参与研究项目提供指导方针。CIBB 基础设施使癌症中心成员能够利用其他不可用的关键数据资源，包括 犹他州大学健康和山间医疗保健数据仓库。癌症中心成员 同行评审资金占用户的11%，与癌症相关的总使用量超过48%。自2014年以来， CQB数据已用于61个以癌症为重点的机构审查委员会（IRB）批准的项目， 出版了118篇论文。 生物医学研究所是一个无与伦比的生物医学研究资源。它提供了出色的数据质量上的大型多 与犹他州癌症监测、流行病学和最终结果（SEER）相关的世代谱系 以及该州大部分的电子病历。CIBB中的数据跨越数十年， 通过其他高质量的数据库和地理编码得到增强，并采用严格的数据质量控制技术， 并以合理的价格提供给癌症中心成员使用IRB批准的方案。CIBB 提高HCI成员的生产力和创造力，并有助于癌症中心的整体发展。 使命，了解癌症的原因，并促进其预防在HCI的集水区，国家 来自犹他州。