Contributions of modifiable physical attributes to cognitive and brain aging

可改变的身体属性对认知和大脑衰老的贡献

基本信息

  • 批准号:
    10212670
  • 负责人:
  • 金额:
    $ 64.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-05-15 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

ABSTRACT With the rapid acceleration of the aging population and repeated failures to find a pharmacological cure for Alzheimer’s disease (AD), it is of paramount importance to identify modifiable physical attributes that are most likely to attenuate cognitive and neural decline in older adults. Individual studies have demonstrated that mobility, cardiorespiratory fitness, and muscle strength/power are associated with cognition among older adults. However, because these physical attributes have been studied in isolation, it remains unknown which of these attributes are most critical for successful cognitive aging and brain maintenance (keeping the brain young). Our long-term goal is to develop a precision medicine model of cognitive aging; that is, to identify which physical attributes are associated with specific cognitive functions and implement individually tailored exercise programs to optimize those cognitive abilities among older adults. Our overall objective in the current proposal is to directly examine differential contributions of mobility, cardiorespiratory fitness, and muscle strength/power metrics to current cognitive abilities, brain health, and longitudinal cognitive decline. Our central hypothesis is that these physical attributes account for unique variance in cognition, but that their relative predictive abilities will differ within specific cognitive domains and neural networks. Using gold-standard assessments of mobility, cardiorespiratory fitness, muscle strength/power, cognition, and brain structure and function (magnetic resonance imaging; MRI) in young, middle-aged, and older adults, we will pursue the following aims: 1) Determine the contribution of physical attributes to cognition, with a specific emphasis on episodic memory and executive function, among older adults. 2) Determine the contribution of physical attributes to cortical thickness (T1-weighted MRI), white matter microstructure (diffusion-weighted MRI) and brain function (functional MRI) among older adults. 3) Identify which physical attributes predict cognitive decline over a 2.5-year period in older adults and whether polygenic risk scores for AD moderate the association between physical attributes and cognitive decline. We will examine which modifiable physical attributes, including functional aspects of the motor system, predict cognitive decline among older adults. Outcome data from this proposal will impact the development of lifestyle interventions for optimization of cognitive performance among older adults, as the study will provide critical knowledge to optimize future exercise intervention studies aimed at mitigating age- and Alzheimer’s disease-related cognitive and neural decline. Moreover, we will examine whether physical attribute-brain-cognition associations are age dependent. The current proposal is well-suited for the mission of the National Institutes of Aging, as we propose to examine modifiable physical attributes that will maximize high quality-of-life years and independent functioning (via maintenance of cognitive and brain health) prior to mortality.
摘要 随着人口老龄化的迅速加速和一再未能找到药物治疗 阿尔茨海默氏病(AD),它是至关重要的,以确定可修改的物理属性,最 可能会减轻老年人的认知和神经衰退。个别研究表明, 活动能力、心肺功能和肌肉力量/力量与老年人的认知能力有关。 成年人了然而,由于这些物理属性是孤立地研究的, 这些属性对于成功的认知老化和大脑维护(保持大脑 young)。我们的长期目标是开发一种认知老化的精准医学模型;也就是说, 哪些物理属性与特定的认知功能相关联, 锻炼计划来优化老年人的认知能力。我们目前的总体目标是 一项建议是直接检查活动性、心肺健康和肌肉的不同贡献 强度/功率指标与当前认知能力、大脑健康和纵向认知衰退的关系。我们的中央 一种假设是,这些物理属性解释了认知中的独特差异,但它们的相对 预测能力在特定的认知域和神经网络内将不同。使用金本位制 评估活动性、心肺功能、肌肉力量/力量、认知和大脑结构, 功能(磁共振成像; MRI)在年轻人,中年人和老年人,我们将追求 以下目标:1)确定物理属性对认知的贡献,特别强调 情景记忆和执行功能。2)确定物质的贡献 归因于皮质厚度(T1加权MRI)、白色微结构(弥散加权MRI)和 脑功能(功能性MRI)在老年人。3)确定哪些物理属性预测认知 老年人在2.5年的时间内下降,以及AD的多基因风险评分是否会减轻 物理属性和认知能力下降之间的关联。我们将研究哪些可修改的物理 属性,包括运动系统的功能方面,预测老年人的认知能力下降。 该提案的结果数据将影响生活方式干预的发展,以优化 老年人的认知表现,因为这项研究将提供关键知识,以优化未来的 运动干预研究旨在减轻年龄和阿尔茨海默病相关的认知和神经 下降此外,我们将研究是否物理属性的大脑认知协会是年龄依赖性。 目前的建议非常适合国家老龄研究所的使命,因为我们建议 检查可改变的身体属性,以最大限度地提高生活质量和独立功能 (via维持认知和大脑健康)。

项目成果

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SCOTT M HAYES其他文献

SCOTT M HAYES的其他文献

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{{ truncateString('SCOTT M HAYES', 18)}}的其他基金

Contributions of modifiable physical attributes to cognitive and brain aging
可改变的身体属性对认知和大脑衰老的贡献
  • 批准号:
    10636963
  • 财政年份:
    2021
  • 资助金额:
    $ 64.8万
  • 项目类别:
Contributions of modifiable physical attributes to cognitive and brain aging
可改变的身体属性对认知和大脑衰老的贡献
  • 批准号:
    10404985
  • 财政年份:
    2021
  • 资助金额:
    $ 64.8万
  • 项目类别:
Exploring real-time alterations in cerebral perfusion, BOLD signal, and cognition during physical activity
探索体力活动期间脑灌注、BOLD 信号和认知的实时变化
  • 批准号:
    9600777
  • 财政年份:
    2018
  • 资助金额:
    $ 64.8万
  • 项目类别:
Effect of aging on item and context memory, neural function, and neural structure
衰老对项目和情境记忆、神经功能和神经结构的影响
  • 批准号:
    7224387
  • 财政年份:
    2007
  • 资助金额:
    $ 64.8万
  • 项目类别:
Effect of aging on item and context memory, neural function, and neural structure
衰老对项目和情境记忆、神经功能和神经结构的影响
  • 批准号:
    7476326
  • 财政年份:
    2007
  • 资助金额:
    $ 64.8万
  • 项目类别:
Effect of aging on item and context memory, neural function, and neural structure
衰老对项目和情境记忆、神经功能和神经结构的影响
  • 批准号:
    7647956
  • 财政年份:
    2007
  • 资助金额:
    $ 64.8万
  • 项目类别:

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