What role does cannabis use have in anxiety? Examining the moderating effect of sensitivity to unpredictable threat.

大麻的使用对焦虑有什么作用？

• 批准号: 10212914
• 负责人: Kelly Correa
• 金额: $ 1.07万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-29 至 2022-08-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212914
• 关键词: Address; Adopted; Affect; Alcohols; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Area; Behavior; Biological; Cannabis; Categories; Child; Data; Development; Diagnosis; Dimensions; Disease; Drug Use Disorder; Drug usage; Ecological momentary assessment; Economics; Electromyography; Event-Related Potentials; Fellowship; Goals; Individual; Individual Differences; Intervention; Knowledge; Laws; Lead; Legal; Longitudinal Studies; Measures; Memory; Mentorship; Methodology; Methods; Moods; National Institute of Mental Health; National Research Service Awards; Outcome; Panic Disorder; Participant; Patient Self-Report; Pharmacology; Phenotype; Physiological; Physiology; Play; Population; Prevalence; Prevention; Process; Property; Psychopathology; Psychophysiology; Public Health; Research; Research Domain Criteria; Research Personnel; Role; Self Medication; Specificity; Statistical Methods; Stimulus; Strategic Planning; Sum; Surveys; Techniques; Testing; Time; Tobacco; Training; Variant; Work; anxiety states; biological adaptation to stress; career; comorbidity; cost; design; experience; innovation; lens; marijuana use; marijuana use disorder; marijuana user; meetings; negative affect; neuroadaptation; novel; prospective; psychologic; psychosocial; skills; social; substance use; trait

Project Summary/Abstract The goals of this fellowship are to further develop the applicant’s knowledge and research skills in anxiety and comorbid disorders, advanced statistical methods (particularly longitudinal methods), and psychophysiology. In line with these goals, the cornerstone of the applicant’s training will be the daily activities associated with the proposed study of the directional relationships between anxiety and cannabis use (i.e., whether anxiety is associated with subsequent cannabis use and/or whether cannabis use is associated with subsequent anxiety) and whether sensitivity to unpredictable threat (SUT) moderates these directional relationships. The project will serve as the applicant’s dissertation and help her pursue her goal of becoming an independent investigator who utilizes psychophysiological techniques to further our understanding of how transdiagnostic constructs, including SUT (one of the main constructs examined in this diversity NRSA application), contribute to vulnerability for anxiety disorders (ADs) and co-occurring psychopathologies. The proposed training plan is multidimensional and includes course work, regular sponsor meetings, statistical training, and professional development activities. In addition to the skills to be gained by the applicant, the project’s goal is consistent with several facets of NIMH’s strategic plans as it has the potential to greatly advance understanding of the processes contributing to why ADs frequently co-occur with cannabis use disorders (CUDs). It is critical to understand the comorbidity between ADs and CUDs as this comorbidity is associated with costly social and economic consequences and rates of CUDs may further increase due to recent changes in social acceptability and state cannabis laws. Ecological momentary assessment (EMA) is a method that can help elucidate the temporal relationship between anxiety and cannabis use as it captures subtle variations in mood and behavior as they occur. The handful of EMA studies on anxiety and cannabis use have been mixed, however, and had several important limitations. Moreover, there are likely specific individual difference factors that impact the association between anxiety and cannabis use. Heightened sensitivity to unpredictable threat (SUT) is one such individual difference factor as it connotes vulnerability for ADs and is also likely to play a role in cannabis use. The present study will therefore utilize a multimethod assessment of SUT (e.g., EMG startle, event-related potentials, and self-report) to test (1) the directional relationship between cannabis use and anxiety (and state experiences of SUT more specifically) and (2) whether trait SUT moderates the temporal relationships between state anxiety (and state SUT) and cannabis use in 60 moderate cannabis users over a 2-week EMA period. Mentorship for this project will be provided by experts in the areas of psychopathology, substance use, EMA, and psychophysiology (sponsors: Shankman and Mermelstein, and collaborator: Childs). This fellowship will not only be an important step in the applicant’s research career, but if the hypotheses are supported, it would help guide the development of novel interventions targeting unique biologic vulnerability processes related to this difficult-to-treat population.

项目总结/摘要 该奖学金的目标是进一步发展申请人在焦虑方面的知识和研究技能 和共病障碍，先进的统计方法（特别是纵向方法），和心理生理学。 根据这些目标，申请人培训的基石将是与 对焦虑和大麻使用之间的方向关系的拟议研究（即，焦虑是否 与随后的大麻使用有关和/或大麻使用是否与随后的焦虑有关） 以及对不可预测威胁的敏感性（SUT）是否调节这些方向关系。该项目将 作为申请人的论文，并帮助她追求成为一名独立调查员的目标， 利用心理生理学技术，以进一步了解如何transdiagnosis结构，包括 SUT（在这个多样性NRSA应用程序中检查的主要结构之一），有助于脆弱性， 焦虑症（AD）和共同发生的精神病理学。拟议的培训计划是多层面的 包括课程工作、定期赞助商会议、统计培训和专业发展活动。 除了申请人获得的技能外，该项目的目标与NIMH的几个方面一致。 战略计划，因为它有可能大大促进对导致AD的过程的理解， 经常与大麻使用障碍（CUD）同时发生。了解广告之间的共通性是至关重要的 和CUDs，因为这种并发症与昂贵的社会和经济后果以及CUDs的发生率有关 由于最近社会接受程度和州大麻法律的变化，可能会进一步增加。 生态瞬时评价（EMA）是一种可以帮助阐明时间关系的方法 焦虑和大麻使用之间的联系，因为它捕捉了情绪和行为发生时的微妙变化。的 然而，少数EMA关于焦虑和大麻使用的研究结果好坏参半， 局限性。此外，可能有特定的个体差异因素影响了 焦虑和大麻的使用对不可预测的威胁（SUT）的高度敏感性就是这样一种个体差异 这是一个因素，因为它意味着对AD的脆弱性，也可能在大麻使用中发挥作用。本研究将 因此利用SUT的多方法评估（例如，EMG惊吓、事件相关电位和自我报告） 测试（1）大麻使用与焦虑之间的方向关系（以及SUT的状态体验） （2）特质SUT是否调节状态焦虑（和状态焦虑）之间的时间关系 SUT）和大麻使用在60中度大麻用户超过2周EMA期间。本项目的导师 将由精神病理学、药物使用、EMA和心理生理学领域的专家提供 （发起人：Shankman和Mermelstein，合作者：查尔兹）。这个奖学金不仅是一个重要的 这是申请人研究生涯中的一步，但如果假设得到支持，它将有助于指导发展 新的干预措施，针对独特的生物脆弱性过程有关的这一难以治疗的人口。