2022 Chromatin Structure and Function GRC and GRS

2022 染色质结构和功能 GRC 和 GRS

• 批准号: 10389240
• 负责人: GEETA J NARLIKAR
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10389240
• 关键词: Access to Information; Address; Affect; Architecture; Area; Behavior; Biology; Biophysics; Cells; Chromatin; Chromatin Modeling; Chromatin Structure; Collaborations; DNA; Disease; Fostering; Genetic Transcription; Genome; Genomics; Histones; International; Mediating; Metabolism; Methodology; Modification; Natural regeneration; Nucleosomes; Oral; Participant; Pathology; Physiology; Play; Process; RNA; RNA Processing; Recording of previous events; Regulation; Request for Proposals; Research; Research Personnel; Role; Schedule; Scientist; Series; Shapes; Spain; Technology; Thinking; Time; Underrepresented Populations; Visualization; Work; chromatin remodeling; cohort; experience; frontier; human disease; innovation; meetings; member; posters; repaired; symposium

Project Summary This proposal requests support for the 2022 GRC and GRS meeting on Chromatin Structure & Function (focus on “Chromatin at the intersection of mechanism and disease”) at the Rey Don Jaime Grand Hotel in Castelldefels, Spain from May 28-June 3, 2022. The 2022 Gordon Conference on Chromatin Structure and Function will bring together an international cohort of outstanding experts to discuss their latest and most exciting research on chromatin as a powerful regulatory platform that shapes genome function. The conference addresses how chromatin regulation impacts all essential DNA-dependent processes, both at the most fundamental and mechanistic level, and at the level of disease pathologies, and therefore is highly significant. The field is evolving at a rapid pace with new methodological advances enabling chromatin mapping and visualization all the way from the level of single loci to a single cell. At the same time new concepts of genome organization are sparking a rethinking of the role of chromatin. Presentations by leading experts will thus cover emerging concepts in chromatin biology, and a wide range of innovative technical approaches to study chromatin organization across multiple scales. Questions that span different conceptual and technical frontiers will be addressed such as: how does chromatin shape and regulate genome architecture; how do histone and RNA modifications interconnect to regulate genome activity; what are the biophysical capabilities of different chromatin states; and how does chromatin mediated regulation interface with metabolism, cellular reprogramming, regeneration, and disease mechanisms. This conference has a long history of attracting top researchers and new entrants in chromatin research. It has been an important forum for fostering new ideas, and collaborations, and this tradition will be continued in 2022. We will continue to integrate new members into this growing field. A large number of talks will be reserved for young scientists and for scientists from under-represented groups, and all applicants will have the opportunity to present a poster on their work. Additionally, “poster previews” will highlight selected posters in short oral presentations. Sufficient discussion time will be scheduled to promote the lively and free exchange of ideas and interpretations and there will be ample time set aside in the afternoons and after the evening sessions for the informal interactions that have always played a key role at this conference. The GRC will be preceded by a GRS which we expect to further enhance interactions and networking among the younger conference participants.

项目概要 该提案请求支持 2022 年 GRC 和 GRS 染色质结构与功能会议（重点 主题为“机制与疾病交叉点的染色质”），于 Rey Don Jaime Grand Hotel 举行 2022年5月28日至6月3日，西班牙卡斯特尔德费尔斯。 2022 年戈登染色质结构与功能会议将汇集一批国际学者 杰出专家讨论他们关于染色质作为强大调节剂的最新、最令人兴奋的研究 塑造基因组功能的平台。会议讨论了染色质调控如何影响所有必需的 DNA 依赖性过程，无论是在最基本和机械层面，还是在疾病层面 病理学，因此非常重要。该领域正在以新的方法论快速发展 技术进步使得染色质绘图和可视化能够从单个基因座水平一直到单个细胞。 与此同时，基因组组织的新概念正在引发人们对染色质作用的重新思考。 因此，顶尖专家的演讲将涵盖染色质生物学的新兴概念以及广泛的 研究多尺度染色质组织的创新技术方法。 将解决跨越不同概念和技术前沿的问题，例如：染色质如何 塑造和调节基因组结构；组蛋白和RNA修饰如何相互连接来调节 基因组活性；不同染色质状态的生物物理能力是什么；以及染色质如何 介导与代谢、细胞重编程、再生和疾病机制的调节界面。 该会议长期以来一直吸引着染色质研究领域的顶尖研究人员和新进入者。它有 是培育新想法和合作的重要论坛，这一传统将在 2022 年继续下去。 我们将继续将新成员融入到这个不断发展的领域。大量会谈将被预留 年轻科学家和来自代表性不足群体的科学家，所有申请人都将有机会 展示他们的作品海报。此外，“海报预览”将以简短的口头形式突出显示选定的海报 演示文稿。安排充足的讨论时间，促进活跃、自由的思想交流和交流 下午和晚间会议之后将留出充足的时间进行口译 非正式互动一直在本次会议上发挥着关键作用。 GRC 之前将有 GRS 我们期望进一步加强年轻与会者之间的互动和联系。