2022 Chromatin Structure and Function GRC and GRS

项目摘要 该提案请求支持2022年GRC和GRS关于染色质结构和功能的会议(焦点 《机制与疾病交汇处的染色质》)年，Rey Don Jaime Grand Hotel 卡斯特尔德费尔斯，西班牙，2022年5月28日至6月3日。 2022年关于染色质结构和功能的戈登会议将汇集国际上 杰出的专家讨论他们关于染色质作为一种强大的调节剂的最新和最令人兴奋的研究 塑造基因组功能的平台。该会议讨论了染色质调节如何影响所有必需的 DNA依赖的过程，无论是在最基本的和机制的层面上，还是在疾病层面上 病理学，因此是非常重要的。这一领域正在以新的方法快速发展 使染色质图谱和可视化从单个基因座水平一直到单个细胞水平的技术进步。 与此同时，基因组组织的新概念正在引发对染色质作用的重新思考。 因此，主要专家的演讲将涵盖染色质生物学中的新兴概念，以及广泛的 研究多尺度染色质组织的创新技术方法。 将讨论跨越不同概念和技术前沿的问题，例如：染色质是如何 塑造和调节基因组结构；组蛋白和RNA修饰如何相互连接以调节 基因组活性；不同染色质状态的生物物理能力是什么；以及染色质是如何 中介调节与新陈代谢、细胞重编程、再生和疾病机制的接口。 这次会议吸引染色质研究领域的顶尖研究人员和新进入者的历史由来已久。它有 作为促进新想法和合作的重要论坛，这一传统将在2022年继续下去。 我们将继续将新成员纳入这一不断增长的领域。大量的会谈将留在 青年科学家和来自代表性不足群体的科学家，所有申请者都将有机会 展示一张关于他们作品的海报。此外，《海报预览》将以简短的口头形式突出精选海报。 演示文稿。将安排足够的讨论时间，促进活跃和自由的思想交流和 口译，下午和晚间会议后将留出充足的时间供 非正式互动一直在本次会议上发挥关键作用。GRC之前将有GRS 我们预计这将进一步加强年轻与会者之间的互动和网络联系。

Project Summary This proposal requests support for the 2022 GRC and GRS meeting on Chromatin Structure & Function (focus on “Chromatin at the intersection of mechanism and disease”) at the Rey Don Jaime Grand Hotel in Castelldefels, Spain from May 28-June 3, 2022. The 2022 Gordon Conference on Chromatin Structure and Function will bring together an international cohort of outstanding experts to discuss their latest and most exciting research on chromatin as a powerful regulatory platform that shapes genome function. The conference addresses how chromatin regulation impacts all essential DNA-dependent processes, both at the most fundamental and mechanistic level, and at the level of disease pathologies, and therefore is highly significant. The field is evolving at a rapid pace with new methodological advances enabling chromatin mapping and visualization all the way from the level of single loci to a single cell. At the same time new concepts of genome organization are sparking a rethinking of the role of chromatin. Presentations by leading experts will thus cover emerging concepts in chromatin biology, and a wide range of innovative technical approaches to study chromatin organization across multiple scales. Questions that span different conceptual and technical frontiers will be addressed such as: how does chromatin shape and regulate genome architecture; how do histone and RNA modifications interconnect to regulate genome activity; what are the biophysical capabilities of different chromatin states; and how does chromatin mediated regulation interface with metabolism, cellular reprogramming, regeneration, and disease mechanisms. This conference has a long history of attracting top researchers and new entrants in chromatin research. It has been an important forum for fostering new ideas, and collaborations, and this tradition will be continued in 2022. We will continue to integrate new members into this growing field. A large number of talks will be reserved for young scientists and for scientists from under-represented groups, and all applicants will have the opportunity to present a poster on their work. Additionally, “poster previews” will highlight selected posters in short oral presentations. Sufficient discussion time will be scheduled to promote the lively and free exchange of ideas and interpretations and there will be ample time set aside in the afternoons and after the evening sessions for the informal interactions that have always played a key role at this conference. The GRC will be preceded by a GRS which we expect to further enhance interactions and networking among the younger conference participants.