Hybrid-FES Exercise to Attenuate Increased Central Adiposity andImprove Glucoregulatory Control in Acute SCI

混合 FES 运动可减轻急性 SCI 中中心性肥胖的增加并改善血糖调节控制

• 批准号: 10389010
• 负责人: Matthew R Ely
• 金额: $ 7.01万
• 依托单位: SPAULDING REHABILITATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10389010
• 关键词: Acute; Adipose tissue; Aerobic; Aerobic Exercise; Attenuated; Award; Blood; Blood Glucose; Body Composition; Buspirone; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Cohort Studies; Data; Dual-Energy X-Ray Absorptiometry; Enrollment; Exercise; Fasting; Fatty acid glycerol esters; Fellowship; Funding; Gene Expression; Glucose tolerance test; Glycosylated hemoglobin A; Health; Hybrids; Impairment; Individual; Insulin; Intervention; Lead; Leg; Leptin; Lung; Mechanics; Metabolic; Metabolic stress; Morbidity - disease rate; Movement; Muscular Atrophy; National Research Service Awards; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Paralysed; Participant; Pharmacologic Substance; Physiological; Placebos; Population; Prevalence; Production; Prospective Studies; Protocols documentation; Regimen; Rehabilitation therapy; Research; Research Personnel; Research Training; Retrospective Studies; Risk; Serotonin Agonists; Serum; Skeletal Muscle; Spinal cord injury; Techniques; Thinness; Tissues; Training; Training Programs; Transforming Growth Factor Beta 2; Visceral; Visceral fat; Work; adipokines; arm; base; blood glucose regulation; cardiovascular disorder risk; cardiovascular risk factor; cohort; energy balance; exercise intensity; exercise training; fasting plasma glucose; follow-up; functional electrical stimulation; glucose metabolism; improved; insulin sensitivity; long-term rehabilitation; metabolic profile; mortality risk; murine nodule inducing virus; muscle form; prevent; programs; reduced muscle mass; rehabilitation strategy; resistin; response; sedentary activity; standard of care; ventilation

ABSTRACT / PROJECT SUMMARY This postdoctoral F32 Kirschstein NRSA proposes unique research and includes a comprehensive training plan in the study of functional electrical stimulation row training (FESRT) as a rehabilitation technique in individuals with spinal cord injuries (SCI). Individuals with spinal cord injuries have a greater morbidity and mortality risk from cardiovascular disease (CVD) than able-bodied individuals. The increased risk could be due, in part, to increased fat mass or dysregulated adipokine production leading to an impaired glucoregulatory control as a result of muscle atrophy and increased sedentary activity. Functional electrical stimulation (FES) exercise is increasingly being used in the acute and long-term rehabilitation of individuals with spinal cord injuries. Our lab uses this technique to induce leg extension and flexion in combination with voluntary upper body movements allowing for whole body rowing (FESRT). This exercise, incorporated into a 6-month training regimen, has been shown to increase aerobic fitness, attenuate gains in fat and loss of paralyzed muscle mass, and control blood glucose; hence, decreasing risk for CVD. However, there is currently a lack of information concerning retention of exercise training adaptations in those with SCI. Therefore, we propose a retrospective study to analyze body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in a group of individuals with SCI (n=31) who participated in 6 months of FESRT and either continued training (n=15) or returned to standard of care (n=16) (AIM 1). Additionally, these beneficial adaptations to FESRT may be proportional to exercise training intensity. Pulmonary limitations in SCI likely limit the attainment of sustainably vigorous FESRT exercise intensities. Therefore, we plan on studying changes in body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in relation to exercise training intensity in a prospective study that incorporates mechanical (non-invasive ventilation) and pharmaceutical (serotonin receptor agonist) ergogenic aids to increase ventilatory capacity (AIM 2). The ultimate purpose of this research is to optimize exercise training protocols for a population that both needs and seeks a broad range of benefits that exercise can confer. This F32 postdoctoral fellowship research and training plan will help develop and optimize rehabilitation strategies in individuals with spinal cord injuries and prepare me to advance as an independent researcher.

摘要/项目摘要 这个博士后F32 Kirschstein NRSA提出了独特的研究，并包括一个 功能性电刺激排训练(FESRT)研究中的综合训练计划 作为脊髓损伤(SCI)患者的康复技术。患有脊椎疾病的个人 脊髓损伤在心血管疾病(CVD)中的发病率和死亡风险比 身体健全的个体。风险的增加可能部分是由于脂肪质量的增加或 脂肪因子产生失调导致糖调节控制受损 肌肉萎缩和久坐活动增加。功能性电刺激(FES) 运动正越来越多地被用于急性和长期康复中 脊髓损伤。我们的实验室使用这种技术来诱导腿部的伸展和屈曲 与自愿上身运动相结合，允许全身划船(FESRT)。 这项训练结合了为期6个月的训练方案，已显示出增加了 有氧健身，减少脂肪增加和瘫痪肌肉的减少，并控制血液 葡萄糖；因此，降低心血管疾病的风险。然而，目前缺乏信息。 关于运动训练适应在脊髓损伤患者中的保留。因此，我们提出一项 体成分、脂肪组织脂肪因子产生、血清分析的回顾性研究 一组脊髓损伤患者的脂肪因子浓度和糖调节控制(n=31) 参加了6个月的FESRT，并继续接受培训(n=15)或返回 护理标准(n=16)(目标1)。此外，对FESRT的这些有益的适应可能是 与运动训练强度成正比。脊髓损伤的肺限制可能会限制获得 可持续的高强度FESRT运动强度。因此，我们计划研究在 身体成分、脂肪组织脂肪因子的产生、血清脂肪因子浓度以及 一项与运动训练强度相关的糖调节控制的前瞻性研究 将机械(无创通风)和药物(5-羟色胺受体)结合在一起 激动剂)用于增加通气量的促红细胞生成素(AIM 2)。这样做的最终目的是 研究旨在为既需要又寻求锻炼的人群优化运动训练方案 锻炼可以带来广泛的好处。这个F32博士后奖学金研究和 训练计划将有助于制定和优化脊椎患者的康复策略 并让我做好准备，成为一名独立的研究人员。