Hybrid-FES Exercise to Attenuate Increased Central Adiposity andImprove Glucoregulatory Control in Acute SCI

混合 FES 运动可减轻急性 SCI 中中心性肥胖的增加并改善血糖调节控制

• 批准号: 10389010
• 负责人: Matthew R Ely
• 金额: $ 7.01万
• 依托单位: SPAULDING REHABILITATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10389010
• 关键词: Acute; Adipose tissue; Aerobic; Aerobic Exercise; Attenuated; Award; Blood; Blood Glucose; Body Composition; Buspirone; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Cohort Studies; Data; Dual-Energy X-Ray Absorptiometry; Enrollment; Exercise; Fasting; Fatty acid glycerol esters; Fellowship; Funding; Gene Expression; Glucose tolerance test; Glycosylated hemoglobin A; Health; Hybrids; Impairment; Individual; Insulin; Intervention; Lead; Leg; Leptin; Lung; Mechanics; Metabolic; Metabolic stress; Morbidity - disease rate; Movement; Muscular Atrophy; National Research Service Awards; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Paralysed; Participant; Pharmacologic Substance; Physiological; Placebos; Population; Prevalence; Production; Prospective Studies; Protocols documentation; Regimen; Rehabilitation therapy; Research; Research Personnel; Research Training; Retrospective Studies; Risk; Serotonin Agonists; Serum; Skeletal Muscle; Spinal cord injury; Techniques; Thinness; Tissues; Training; Training Programs; Transforming Growth Factor Beta 2; Visceral; Visceral fat; Work; adipokines; arm; base; blood glucose regulation; cardiovascular disorder risk; cardiovascular risk factor; cohort; energy balance; exercise intensity; exercise training; fasting plasma glucose; follow-up; functional electrical stimulation; glucose metabolism; improved; insulin sensitivity; long-term rehabilitation; metabolic profile; mortality risk; murine nodule inducing virus; muscle form; prevent; programs; reduced muscle mass; rehabilitation strategy; resistin; response; sedentary activity; standard of care; ventilation

ABSTRACT / PROJECT SUMMARY This postdoctoral F32 Kirschstein NRSA proposes unique research and includes a comprehensive training plan in the study of functional electrical stimulation row training (FESRT) as a rehabilitation technique in individuals with spinal cord injuries (SCI). Individuals with spinal cord injuries have a greater morbidity and mortality risk from cardiovascular disease (CVD) than able-bodied individuals. The increased risk could be due, in part, to increased fat mass or dysregulated adipokine production leading to an impaired glucoregulatory control as a result of muscle atrophy and increased sedentary activity. Functional electrical stimulation (FES) exercise is increasingly being used in the acute and long-term rehabilitation of individuals with spinal cord injuries. Our lab uses this technique to induce leg extension and flexion in combination with voluntary upper body movements allowing for whole body rowing (FESRT). This exercise, incorporated into a 6-month training regimen, has been shown to increase aerobic fitness, attenuate gains in fat and loss of paralyzed muscle mass, and control blood glucose; hence, decreasing risk for CVD. However, there is currently a lack of information concerning retention of exercise training adaptations in those with SCI. Therefore, we propose a retrospective study to analyze body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in a group of individuals with SCI (n=31) who participated in 6 months of FESRT and either continued training (n=15) or returned to standard of care (n=16) (AIM 1). Additionally, these beneficial adaptations to FESRT may be proportional to exercise training intensity. Pulmonary limitations in SCI likely limit the attainment of sustainably vigorous FESRT exercise intensities. Therefore, we plan on studying changes in body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in relation to exercise training intensity in a prospective study that incorporates mechanical (non-invasive ventilation) and pharmaceutical (serotonin receptor agonist) ergogenic aids to increase ventilatory capacity (AIM 2). The ultimate purpose of this research is to optimize exercise training protocols for a population that both needs and seeks a broad range of benefits that exercise can confer. This F32 postdoctoral fellowship research and training plan will help develop and optimize rehabilitation strategies in individuals with spinal cord injuries and prepare me to advance as an independent researcher.

摘要/项目总结 这个博士后F32 Kirschstein NRSA提出了独特的研究，包括一个 功能性电刺激划船训练（FESRT）研究中的综合训练计划 作为脊髓损伤（SCI）患者的康复技术。患有脊柱 脊髓损伤的心血管疾病（CVD）发病率和死亡率风险高于 健全的个体。增加的风险可能部分是由于脂肪量增加或 脂肪因子产生失调导致糖调节控制受损， 肌肉萎缩和久坐活动增加。功能性电刺激（FES） 运动越来越多地被用于急性和长期康复的个人， 脊髓损伤我们的实验室使用这种技术来诱导腿部伸展和屈曲， 结合自愿的上身运动，允许全身划船（FESRT）。 这项运动，纳入6个月的训练方案，已被证明可以增加 有氧健身，减少脂肪的增加和瘫痪肌肉的减少，并控制血液 葡萄糖;因此，降低CVD的风险。然而，目前缺乏信息， 关于SCI患者运动训练适应性的保留。因此，我们建议 回顾性研究，分析身体组成、脂肪组织脂肪因子产生、血清 一组SCI患者的脂肪因子浓度和葡萄糖调节控制（n=31） 参加6个月FESRT并继续训练（n=15）或返回 标准治疗（n=16）（AIM 1）。此外，这些对FESRT的有益适应可能是 与运动训练强度成正比。SCI患者的肺部限制可能限制了 可持续的高强度FESRT运动强度。因此，我们计划研究 身体组成、脂肪组织脂肪因子产生、血清脂肪因子浓度，以及 在一项前瞻性研究中， 结合机械（无创通气）和药物（血清素受体 激动剂），以增加排泄能力（AIM 2）。这样做的最终目的 研究是为了优化运动训练协议的人口，既需要和寻求 锻炼可以带来的广泛益处。这个F32博士后奖学金研究和 训练计划将有助于制定和优化脊柱关节炎患者的康复策略。 脊髓损伤让我成为独立研究者