Hybrid-FES Exercise to Attenuate Increased Central Adiposity andImprove Glucoregulatory Control in Acute SCI

混合 FES 运动可减轻急性 SCI 中中心性肥胖的增加并改善血糖调节控制

• 批准号: 10676720
• 负责人: Matthew R Ely
• 金额: $ 2.96万
• 依托单位: SPAULDING REHABILITATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-07-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10676720
• 关键词: Acute; Adipose tissue; Aerobic; Aerobic Exercise; Attenuated; Award; Blood; Blood Glucose; Body Composition; Buspirone; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Cohort Studies; Data; Dual-Energy X-Ray Absorptiometry; Enrollment; Exercise; Fasting; Fatty acid glycerol esters; Fellowship; Funding; Gene Expression; Glucose tolerance test; Glycosylated hemoglobin A; Health; Hybrids; Impairment; Individual; Insulin; Intervention; Leg; Leptin; Lung; Mechanics; Metabolic; Metabolic stress; Morbidity - disease rate; Movement; Muscular Atrophy; National Research Service Awards; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Paralysed; Participant; Pharmacologic Substance; Physiological; Placebos; Population; Postdoctoral Fellow; Prevalence; Production; Prospective Studies; Protocols documentation; Regimen; Rehabilitation therapy; Research; Research Personnel; Retrospective Studies; Risk; Serotonin Agonists; Serum; Skeletal Muscle; Spinal cord injury; Techniques; Thinness; Tissues; Training; Training Programs; Transforming Growth Factor Beta 2; Visceral; Visceral fat; Work; adipokines; arm; blood glucose regulation; cardiovascular disorder risk; cardiovascular risk factor; cohort; energy balance; exercise intensity; exercise training; fasting plasma glucose; follow-up; functional electrical stimulation; glucose metabolism; improved; insulin sensitivity; long-term rehabilitation; metabolic profile; mortality risk; murine nodule inducing virus; muscle form; obese person; prevent; programs; reduced muscle mass; rehabilitation strategy; resistin; response; sedentary activity; standard of care; ventilation

ABSTRACT / PROJECT SUMMARY This postdoctoral F32 Kirschstein NRSA proposes unique research and includes a comprehensive training plan in the study of functional electrical stimulation row training (FESRT) as a rehabilitation technique in individuals with spinal cord injuries (SCI). Individuals with spinal cord injuries have a greater morbidity and mortality risk from cardiovascular disease (CVD) than able-bodied individuals. The increased risk could be due, in part, to increased fat mass or dysregulated adipokine production leading to an impaired glucoregulatory control as a result of muscle atrophy and increased sedentary activity. Functional electrical stimulation (FES) exercise is increasingly being used in the acute and long-term rehabilitation of individuals with spinal cord injuries. Our lab uses this technique to induce leg extension and flexion in combination with voluntary upper body movements allowing for whole body rowing (FESRT). This exercise, incorporated into a 6-month training regimen, has been shown to increase aerobic fitness, attenuate gains in fat and loss of paralyzed muscle mass, and control blood glucose; hence, decreasing risk for CVD. However, there is currently a lack of information concerning retention of exercise training adaptations in those with SCI. Therefore, we propose a retrospective study to analyze body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in a group of individuals with SCI (n=31) who participated in 6 months of FESRT and either continued training (n=15) or returned to standard of care (n=16) (AIM 1). Additionally, these beneficial adaptations to FESRT may be proportional to exercise training intensity. Pulmonary limitations in SCI likely limit the attainment of sustainably vigorous FESRT exercise intensities. Therefore, we plan on studying changes in body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in relation to exercise training intensity in a prospective study that incorporates mechanical (non-invasive ventilation) and pharmaceutical (serotonin receptor agonist) ergogenic aids to increase ventilatory capacity (AIM 2). The ultimate purpose of this research is to optimize exercise training protocols for a population that both needs and seeks a broad range of benefits that exercise can confer. This F32 postdoctoral fellowship research and training plan will help develop and optimize rehabilitation strategies in individuals with spinal cord injuries and prepare me to advance as an independent researcher.

摘要/项目摘要 这位 F32 Kirschstein NRSA 博士后提出了独特的研究，包括 功能性电刺激划船训练（FESRT）研究中的综合训练计划 作为脊髓损伤 (SCI) 患者的一种康复技术。有脊椎病的人 与脊髓损伤相比，心血管疾病 (CVD) 导致脊髓损伤的发病率和死亡风险更高 身体健全的个人。风险增加的部分原因可能是脂肪量增加或 脂肪因子产生失调，导致葡萄糖调节控制受损 肌肉萎缩和久坐活动增加。功能性电刺激（FES） 运动越来越多地用于患有以下疾病的人的急性和长期康复 脊髓损伤。我们的实验室使用这种技术来诱导腿部伸展和弯曲 与自愿上半身运动相结合，允许全身划船（FESRT）。 这项练习纳入为期 6 个月的训练方案中，已被证明可以提高 有氧健身，减少脂肪增加和麻痹肌肉质量损失，并控制血液 葡萄糖;因此，降低心血管疾病的风险。但目前缺乏相关信息 关于 SCI 患者保留运动训练适应性。因此，我们提出一个 回顾性研究分析身体成分、脂肪组织脂肪因子的产生、血清 一组 SCI 个体的脂肪因子浓度和葡萄糖调节控制 (n=31) 参加了 6 个月的 FESRT 并继续接受培训 (n=15) 或返回 标准护理 (n=16) (AIM 1)。此外，这些对 FESRT 的有益适应可能是 与运动训练强度成正比。 SCI 中的肺部限制可能会限制其实现 持续剧烈的 FESRT 运动强度。因此，我们计划研究变化 身体成分、脂肪组织脂肪因子产生、血清脂肪因子浓度，以及 在一项前瞻性研究中，血糖调节控制与运动训练强度相关 结合了机械（无创通气）和药物（血清素受体） 激动剂）强效剂有助于增加通气能力（AIM 2）。这样做的最终目的 研究的目的是为需要并寻求运动的人群优化运动训练方案 锻炼可以带来广泛的好处。这项 F32 博士后奖学金研究和 培训计划将有助于制定和优化脊柱患者的康复策略 脊髓损伤，让我为成为一名独立研究员做好准备。