Mapping the Neural Organization of Language from Words to Syntax

将语言的神经组织从单词映射到句法

• 批准号: 10390289
• 负责人: Gregory Hickok
• 金额: $ 20.51万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10390289
• 关键词: Acquired Language Disorders; Agrammatism; Anatomic Models; Anterior; Aphasia; Assessment tool; Brain; Clinic; Clinical Research; Clinical Trials; Code; Communication; Competence; Comprehension; Data; Data Set; Development; Diagnosis; Diagnostic Specificity; Disease; Evaluation; Functional disorder; Goals; Grant; Impairment; Individual; Language; Linguistics; Maps; Measurement; Measures; Modeling; Motor; Names; Nature; North America; Outcome; Outcome Measure; Paint; Patients; Persons; Play; Probability; Process; Production; Prognosis; Psycholinguistics; Public Health; Publishing; Quality of life; Recovery; Resolution; Semantics; Speech; Structure of middle temporal gyrus; Superior temporal gyrus; Taxes; Temporal Lobe; Testing; Theoretical model; Treatment outcome; Trees; Work; angular gyrus; aphasia recovery; clinical application; clinically relevant; improved; lexical; motor control; neural model; neural network; next generation; phonology; predictive modeling; relating to nervous system; response; success; syntax; targeted treatment; theories; tool

Summary (Project 4) Acquired disorders of language, such as aphasia, can have devastating effects on an individual’s quality of life and livelihood. Up to 2,000,000 people in North America have aphasia making it a significant public health concern. The goal of Project 4 is to improve our ability to diagnosis, treat, and predict recovery from aphasia using quantitative and theoretical models of how language works and how it is implemented in the brain. As part of the Center for the Study of Aphasia Recovery (C-STAR), this project has three specific aims: (1) to apply our MPT model to treatment outcome evaluation and recovery prediction, (2) to extend our quantitative and neural model of word production, and (3) to extend our theoretical scope to include syntax. Although Project 4 has a bit more theoretical slant that the other three Projects, we have made a concerted effort to also emphasize the clinical application of the project.

摘要（项目4） 后天性语言障碍，如失语症，会对一个人产生毁灭性的影响。 个人的生活质量和生计。在北美有200万人患有失语症 使其成为重大的公共卫生问题。项目4的目标是提高我们的能力， 使用失语症的定量和理论模型诊断、治疗和预测失语症的恢复。 语言是如何工作的以及它是如何在大脑中实现的。作为研究中心的一部分， 本课题的主要目的是：（1）应用我们的MPT模型， 治疗结果评估和恢复预测，（2）扩展我们的定量和 词产生的神经模型，（3）扩大我们的理论范围，包括句法。 虽然项目4比其他三个项目有更多的理论倾向，但我们已经做出了 一个共同的努力，也强调该项目的临床应用。