Neurobiology of Auditory Language Perception

听觉语言感知的神经生物学

• 批准号: 7850187
• 负责人: Gregory Hickok
• 金额: $ 29.14万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850187
• 关键词: Adopted; Anterior; Auditory; Brain region; Cereals; Comprehension; Dorsal; Functional Magnetic Resonance Imaging; Goals; Language; Left; Lesion; Linguistics; Maps; Methods; Music; Neurobiology; Perception; Process; Research; Semantics; Staging; Stream; Structure; Structure of middle temporal gyrus; Structure of superior temporal sulcus; Superior temporal gyrus; Support System; System; Temporal Lobe; Work; auditory comprehension; language perception; lexical; phonology; programs; relating to nervous system; research study; syntax

We employ functional MRI and lesion methods to map cortical systems supporting the perception and comprehension of auditory language. The studies are theoretically guided on the broadest scale by our dorsal-ventral framework for the neural organization of language, which holds that the majority of computational systems supporting language comprehension (the ventral stream) are located in the temporal lobe. We target three broad computational systems: (1) phonological-level systems, (2) sentence-level systemss, and (3) lexical-semantic-level systems which are juxtaposed between, and interact with (1) & (2). Thus, the present proposal aims to map the large-scale landscape of language perception/comprehension systems. Aim 1: To map cortical regions supporting phonological-level processes, their interaction with lexical-semantic systems, and their relation to non-linguistic processes. A major goal is to distinguish systems supporting sublexical (segmental) and lexical (word) stages of phonological processing/representation. Experiments proposed in this section are guided by the following hypotheses, (i) Sublexical processes are computed on dorsal aspects of the superior temporal gyrus (STG) whereas lexical- level phonological processes involve ventral aspects of the STG. (ii)Neural structures in the posterior middle temporal gyrus (pMTG), interface lexical-phonological systems with widely distributed lexical- semantic networks, (iii)Phonological systems, both sublexical and lexical, are bilaterally organized, while the proposed phonological-semantic interface system is more left dominant. Aim 2: To map cortical regions supporting sentence-level processes, their interaction with lexical-semantic systems, and their interaction with non-linguistic processes. Experiments proposed in this section are guided by the following hypotheses, (i) Sentence-level processes involve fields in the anterior temporal lobe (ATL), and interacts with lexical- semantic networks via a posterior temporal lobe interface network, (ii)Processing phrasal prosody involves anterior portions of the STG, whereas syntactic processes involve more ventral anterior STS/MTG regions, (iii) Systems supporting the processing of phrasal prosody share neural territory with non-linguistic auditory processes (e.g..music), whereas syntactic processes are carried out in circumscribed and domain-specific brain regions.

我们采用功能性MRI和损伤方法来映射支持感知的皮层系统， 听觉语言的理解。这些研究在理论上得到我们最广泛的指导。 背腹框架的神经组织的语言，认为大多数 支持语言理解的计算系统（腹侧流）位于颞叶， 耳垂。我们针对三个广泛的计算系统：（1）语音级系统，（2）语音级系统， 系统，以及（3）词汇语义层系统，它们在（1）和（2）之间并置，并与（1）和（2）交互。 因此，本提案旨在绘制语言感知/理解的大规模景观 系统.目的1：绘制支持语音水平过程的皮层区域， 词汇语义系统，以及它们与非语言过程的关系。一个主要目标是区分 系统支持的亚词汇（段）和词汇（词）阶段的语音 处理/表示。本节中提出的实验由以下假设指导，（i） 亚词汇过程计算在上级颞回（STG）的背侧，而词汇- 水平语音过程涉及腹侧方面的STG。（二）后部的神经结构 颞中回（pMTG），词汇-语音系统的界面，广泛分布的词汇- 语义网络，（iii）语音系统，包括词汇和词汇，是双边组织的，而 提出的语音-语义界面系统是更左优势。目的2：映射皮质区域 支持语义层次的过程，它们与词汇语义系统的相互作用，以及它们之间的相互作用 非语言过程。本节中提出的实验由以下假设指导， (i)句子层面的加工涉及前颞叶（ATL），并与词汇- 语义网络通过后颞叶接口网络，（ii）处理短语韵律涉及 STG的前部，而句法过程涉及更多腹侧前部STS/MTG区域， (iii)支持短语韵律处理的系统与非语言听觉系统共享神经领域 过程（例如，音乐），而句法过程是在有限的和特定的领域进行的 大脑区域。