The role of epigenetic modifiers in regulating the developmental plasticity of cranial neural crest cells

表观遗传修饰剂在调节颅神经嵴细胞发育可塑性中的作用

基本信息

  • 批准号:
    10211467
  • 负责人:
  • 金额:
    $ 22.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-01 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

Summary How stem progenitor cells maintain plasticity for proper cell fate determination over developmental time is a fundamental question in developmental biology and regenerative medicine. Cranial neural crest cells (cNCCs) are an excellent example of a well defined cellular lineage transition in which multipotent cells step through a series of more restricted progenitors to give rise to diverse array of differentiated cell types, including neurons and glia of the peripheral nervous system as well as craniofacial cartilage and bone. Thus, understanding the genetic and epigenetic regulators in cNCC development is key to understanding how cell fate is determined as well as how cells can be reprogrammed. We hypothesize that the cNCC cartilage/neuron/glial progenitor retains plasticity through developmental time and cNCC fate acquisition is controlled by regulation of chromatin accessibility by prdm3. The rationale for the proposed studies is that an in-depth understanding of the specific factors involved in cNCC lineage transitions will provide insights into both normal developmental plasticity of cNCCs as well as how progenitors can be reprogramed for tissue repair. We will test this hypothesis in the following specific aims: 1) Test the hypothesis that prdm3 acts as a molecular cell fate switch during cNCC differentiation. Here we will test the hypothesis that prdm3 activity is required in cNCCs cell autonomously to promote the temporal recruitment of progenitors to cartilage by repressing neuronal cell fate. 2) Test the hypothesis that the cartilage/neuronal/glial (CNG) progenitor retains plasticity through developmental time and can be reprogramed by loss of prdm3. In Aim 2, hypothesis that CNG progenitors retain plasticity over developmental time and into larval stages and are reprogramed with loss of prdm3. 3) Test the hypothesis that Prdm3 regulates the timing of cNCC differentiation by controlling of genomic accessibility. In Aim 3, we will test the hypothesis that loss of Prdm3 leads to global alterations in chromatin state at cNCC progenitor genes, which in turn controls the timing of differentiation. Together, these studies will reveal basic information of how cNCCs differentiate into specific cell types during development. The results of this proposal have the potential to reveal important new insights into normal developmental plasticity of cNCCs such that tissue reprograming can be developed for the repair of damaged craniofacial tissues.
总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Kristin Artinger其他文献

Kristin Artinger的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Kristin Artinger', 18)}}的其他基金

The role of epigenetic modifiers in regulating the developmental plasticity of cranial neural crest cells
表观遗传修饰剂在调节颅神经嵴细胞发育可塑性中的作用
  • 批准号:
    10805033
  • 财政年份:
    2023
  • 资助金额:
    $ 22.77万
  • 项目类别:
Reprogramming myogenic regulatory factors in RMS to promote differentiation and halt growth
重新编程 RMS 中的生肌调节因子以促进分化并阻止生长
  • 批准号:
    10682281
  • 财政年份:
    2023
  • 资助金额:
    $ 22.77万
  • 项目类别:
Genetic and epigenetic regulation of cranial neural crest differentiation
颅神经嵴分化的遗传和表观遗传调控
  • 批准号:
    10817293
  • 财政年份:
    2023
  • 资助金额:
    $ 22.77万
  • 项目类别:
Genetic and epigenetic regulation of cranial neural crest differentiation
颅神经嵴分化的遗传和表观遗传调控
  • 批准号:
    10316019
  • 财政年份:
    2021
  • 资助金额:
    $ 22.77万
  • 项目类别:
The role of epigenetic modifiers in regulating the developmental plasticity of cranial neural crest cells
表观遗传修饰剂在调节颅神经嵴细胞发育可塑性中的作用
  • 批准号:
    10352461
  • 财政年份:
    2021
  • 资助金额:
    $ 22.77万
  • 项目类别:
Genetic and epigenetic regulation of cranial neural crest differentiation
颅神经嵴分化的遗传和表观遗传调控
  • 批准号:
    10442617
  • 财政年份:
    2021
  • 资助金额:
    $ 22.77万
  • 项目类别:
Mechanistic analysis of novel genetic loci for split hand foot malformation
手足劈裂畸形新基因位点的机制分析
  • 批准号:
    9906909
  • 财政年份:
    2019
  • 资助金额:
    $ 22.77万
  • 项目类别:
The mechanisms regulating actin dynamics and polarized membrane transport during cell migration
细胞迁移过程中调节肌动蛋白动力学和极化膜运输的机制
  • 批准号:
    10536451
  • 财政年份:
    2018
  • 资助金额:
    $ 22.77万
  • 项目类别:
The mechanisms regulating actin dynamics and polarized membrane transport during cell migration
细胞迁移过程中调节肌动蛋白动力学和极化膜运输的机制
  • 批准号:
    10693336
  • 财政年份:
    2018
  • 资助金额:
    $ 22.77万
  • 项目类别:
Function of chromatin modifiers in cranial neural crest development
染色质修饰剂在颅神经嵴发育中的作用
  • 批准号:
    8913662
  • 财政年份:
    2015
  • 资助金额:
    $ 22.77万
  • 项目类别:

相似海外基金

Bridging the Gap: Next-Gen Tools for Accurate Prediction of Disordered Protein Binding Sites
弥合差距:准确预测无序蛋白质结合位点的下一代工具
  • 批准号:
    24K15172
  • 财政年份:
    2024
  • 资助金额:
    $ 22.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Design of protein crystal templates with multiple binding sites for tracking metal complex reactions.
设计具有多个结合位点的蛋白质晶体模板,用于跟踪金属络合物反应。
  • 批准号:
    23K04928
  • 财政年份:
    2023
  • 资助金额:
    $ 22.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Dynamic changes in PIP2 binding sites and their impact on axonal targeting and function of epilepsy-associated KCNQ/Kv7 channels
PIP2 结合位点的动态变化及其对癫痫相关 KCNQ/Kv7 通道的轴突靶向和功能的影响
  • 批准号:
    10744934
  • 财政年份:
    2023
  • 资助金额:
    $ 22.77万
  • 项目类别:
Computational methods to identify small molecule RNA binding sites
识别小分子 RNA 结合位点的计算方法
  • 批准号:
    573688-2022
  • 财政年份:
    2022
  • 资助金额:
    $ 22.77万
  • 项目类别:
    University Undergraduate Student Research Awards
Identification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channels
环核苷酸调节通道变构网络内潜在药物结合位点的鉴定
  • 批准号:
    10704557
  • 财政年份:
    2022
  • 资助金额:
    $ 22.77万
  • 项目类别:
Identification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channels
环核苷酸调节通道变构网络内潜在药物结合位点的鉴定
  • 批准号:
    10537846
  • 财政年份:
    2022
  • 资助金额:
    $ 22.77万
  • 项目类别:
Identifying new types of inhibitors in quinone binding sites in photosynthetic enzymes
鉴定光合酶醌结合位点的新型抑制剂
  • 批准号:
    2753921
  • 财政年份:
    2022
  • 资助金额:
    $ 22.77万
  • 项目类别:
    Studentship
Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites
开发针对不同冠状病毒受体结合位点的广泛纳米疫苗
  • 批准号:
    10328140
  • 财政年份:
    2022
  • 资助金额:
    $ 22.77万
  • 项目类别:
Exploiting Water Network Perturbations in Protein Binding Sites
利用蛋白质结合位点的水网络扰动
  • 批准号:
    10621368
  • 财政年份:
    2021
  • 资助金额:
    $ 22.77万
  • 项目类别:
SBIR Phase I: Nonlinear optical method for identifying protein-ligand binding sites
SBIR 第一阶段:识别蛋白质-配体结合位点的非线性光学方法
  • 批准号:
    2111821
  • 财政年份:
    2021
  • 资助金额:
    $ 22.77万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了