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Social Reward Processing Across the Lifespan: Identifying Risk Factors for Financial Exploitation

整个生命周期的社会奖励处理：识别金融剥削的风险因素

基本信息

批准号：
10213369
负责人：
David Victor Smith
金额：
$ 197.5万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10213369
关键词：
21 year old Address Adult Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Anterior Attenuated Brain Brain region Corpus striatum structure Data Decision Making Dementia Economics Elderly Ethnic Origin Exhibits Family Foundations Fraud Friends Future Goals Health Health Status Impaired cognition Individual Link Longevity Nature Neurocognitive Neuropsychology Parietal Participant Patient Self-Report Pattern Prefrontal Cortex Process Questionnaires Rest Rewards Risk Risk Factors Role Sampling Social Environment Social Network Social support Socioeconomic Status System Testing Time Translations Trust Vascular Cognitive Impairment Vascular Dementia Visit Vulnerable Populations White Matter Hyperintensity Withdrawal Work age difference age related base cingulate cortex cognitive ability cognitive function depressive symptoms executive function experience experimental study financial decision making financial exploitation health assessment information processing insight low socioeconomic status mild cognitive impairment neuroimaging neuromechanism novel peer recruit relating to nervous system response reward processing sex social social engagement sociodemographic factors sociodemographic variables white matter willingness young adult

项目摘要

Project Summary Older adults are often victims of financial exploitation, which results in annual losses of at least $3 billion. Threat of exploitation may be greater in those at risk for Alzheimer's Disease and Related Dementias (ADRD). While most cases of financial exploitation are perpetrated by strangers, perpetration by individuals within the victim's social network (e.g., friends and family) is common. Although these observations highlight the social nature of financial exploitation, we know very little about how neural systems in older adults and those at risk for ADRD integrate information from the social domain to inform financial decision making. Tasks involving social information processing evoke activation in the temporal-parietal junction (TPJ) and dorsomedial prefrontal cortex; whereas tasks involving financial decision making and reward processing evoke activation in the striatum and ventromedial prefrontal cortex. It remains unclear whether responses within these neural systems—and connectivity between them and other regions—differ as a function of age and risk for financial exploitation. We recently demonstrated age differences in TPJ response during social decision-making in the context of financial exchange (e.g., trust and fairness). We have also shown that the influence of social context (e.g., presence of a peer) on striatal responses to reward is attenuated in older adults relative to younger adults. Building on these exciting preliminary data, the goal of the current proposal is to characterize neural responses during social decision making and reward processing across adulthood and quantify how these responses relate to risk for financial exploitation. We will recruit a large sample of adults (ages 21 to 80+ years) to participate in a neuroimaging experiment investigating social reward processing and the interplay between social context and financial decision making. We will also administer neuropsychological and health assessments, as well as questionnaires assessing socioemotional functioning and risk for financial exploitation. Our project will address four aims. We will examine how neural responses to social and nonsocial reward and decisions based on trust and fairness differ across the lifespan (Aim 1). Although neural responses evoked by our tasks may be associated with risk for financial exploitation, it is imperative to determine how such responses interact with sociodemographic factors, cognitive decline, socioemotional functioning, and health (Aim 2). Notably, our quantification of health status will leverage two understudied risk factors for ADRD—vascular health and white matter hyperintensities—and relate these factors to financial exploitation. Finally, we will re-test a subset of participants with mild cognitive impairment (MCI) two years after their baseline visit and assess changes in social reward processing and risk for financial exploitation (Aim 3). Overall, our project will generate new insights into the interplay between social and financial decision making across the lifespan and individuals at risk for ADRD and start the road to translation by characterizing risk factors for financial exploitation among vulnerable groups.

项目摘要老年人往往是金融剥削的受害者，每年造成至少30亿美元的损失。剥削的威胁可能更大的风险，阿尔茨海默氏病和相关痴呆症（ADRD）。虽然大多数金融剥削案件是由陌生人犯下的，但受害者的社交网络（例如，朋友和家人）是常见的。虽然这些观察结果突出了社会金融剥削的本质，我们对老年人和处于风险中的人的神经系统如何知道得很少。对于ADRD，整合来自社交领域的信息，为财务决策提供信息。所涉及的任务社会信息处理引起颞顶交界区（TPJ）和背内侧区的激活前额叶皮层;而涉及财务决策和奖励处理的任务则会激活纹状体和腹内侧前额叶皮质。目前尚不清楚这些神经元内的反应是否系统-以及它们与其他地区之间的连通性-因年龄和金融风险而异剥削我们最近证明了年龄差异TPJ反应在社会决策过程中，金融交易的背景（例如，信任与公平）。我们还表明，社会背景的影响 (e.g.,同龄人的存在）对纹状体奖励反应的影响在老年人中相对于年轻人减弱成年人了在这些令人兴奋的初步数据的基础上，当前提案的目标是描述神经系统的特征。在整个成年期的社会决策和奖励处理过程中的反应，并量化这些反应是如何发生的。答复涉及金融剥削的风险。我们将招募大量成年人样本（年龄21至80岁以上）参与一项神经成像实验，研究社会奖励过程以及社会背景和财务决策。我们还将管理神经心理学和健康评估，以及评估社会情绪功能和财务风险的问卷剥削我们的项目将实现四个目标。我们将研究如何神经反应的社会和非社会基于信任和公平的奖励和决策在整个生命周期中是不同的（目标1）。虽然神经反应我们的任务引发的风险可能与金融剥削风险有关，因此必须确定如何这些反应与社会人口因素、认知能力下降、社会情绪功能和健康（目标2）。值得注意的是，我们对健康状况的量化将利用两个未充分研究的风险因素，血管健康和白色物质高密度，并将这些因素与经济剥削。最后，我们将重新测试一部分轻度认知障碍（MCI）的参与者，他们在两年后，基线访问和评估社会奖励处理和金融剥削风险的变化（目标3）。总的来说，我们的项目将对社会和财务决策之间的相互作用产生新的见解在整个生命周期和个体中存在ADRD风险，并通过描述风险开始转化之路在弱势群体中进行经济剥削的因素。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Social Context and Reward Sensitivity Enhance Corticostriatal Function during Experiences of Shared Rewards.

社会背景和奖励敏感性在共享奖励的经历中增强皮质纹状体功能。

DOI：
10.1101/2023.10.19.562908
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Zaff,Ori;Wyngaarden,JamesB;Dennison,JeffreyB;Sazhin,Daniel;Chein,Jason;McCloskey,Michael;Alloy,LaurenB;Jarcho,JohannaM;Smith,DavidV;Fareri,DominicS
通讯作者：
Fareri,DominicS

An fMRI Dataset on Social Reward Processing and Decision Making in Younger and Older Adults.

DOI：
10.1038/s41597-024-02931-y
发表时间：
2024-02-01
期刊：
Scientific data
影响因子：
9.8
作者：
Smith DV;Ludwig RM;Dennison JB;Reeck C;Fareri DS
通讯作者：
Fareri DS

Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease.

DOI：
10.1038/s41598-022-07020-x
发表时间：
2022-02-28
期刊：
Scientific reports
影响因子：
4.6
作者：
O'Shea IM;Popal HS;Olson IR;Murty VP;Smith DV
通讯作者：
Smith DV

Tensorial independent component analysis reveals social and reward networks associated with major depressive disorder.

张力独立的组件分析揭示了与重度抑郁症相关的社会和奖励网络。

DOI：
10.1002/hbm.26254
发表时间：
2023-05
期刊：
Human brain mapping
影响因子：
4.8
作者：
通讯作者：

DOI：
10.1016/j.neuroimage.2022.119267
发表时间：
2022-08-01
期刊：
NEUROIMAGE
影响因子：
5.7
作者：
Fareri, Dominic S.;Hackett, Katherine;Tepfer, Lindsey J.;Kelly, Victoria;Henninger, Nicole;Reeck, Crystal;Giovannetti, Tania;Smith, David, V
通讯作者：
Smith, David, V