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Understanding Functional Connectivity Abnormalities In Individual Patients with Psychosis

了解精神病个体患者的功能连接异常

基本信息

批准号：
10213601
负责人：
Danhong Wang
金额：
$ 18.61万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-18 至 2023-05-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10213601
关键词：
Affect Applications Grants Area Biology Bipolar Disorder Brain Brain Pathology Brain region Characteristics Clinical Clinical Research Cognitive Consensus Data Data Set Development Diagnosis Diagnostic Face Foundations Functional Imaging Functional Magnetic Resonance Imaging General Hospitals Goals Heterogeneity Hospitals Human Image Individual Investigation K-Series Research Career Programs Laboratory Study Lesion Link Literature Maps Massachusetts Measures Mental disorders Mentored Research Scientist Development Award Mentors Methods Nature Neuroanatomy Neurobiology Neurosciences Pathologic Patients Pattern Pharmacology Physicians Physiology Portraits Protocols documentation Psychology Psychopathology Psychoses Psychotic Disorders Radiology Specialty Reproducibility Research Research Personnel Research Project Grants Scanning Schizoaffective Disorders Schizophrenia Scientist Series Severities Solid Specific qualifier value Subgroup Symptoms Syndrome Techniques Technology Time Training United States National Institutes of Health Universities Variant base career career development cohort connectome cortex mapping experimental study flexibility grasp individual patient insight large scale data medical schools mid-career faculty neural circuit neuroimaging patient oriented patient oriented research professor psychotic symptoms support vector machine tool

项目摘要

Abstract This is an application for a K01 award for Dr. Danhong Wang, a physician-scientist at Massachusetts General Hospital and Harvard Medical School. Dr. Wang is establishing herself as a young investigator in patient- oriented neuroimaging research on psychiatric disorders. This K01 award will provide Dr. Wang with the support necessary to accomplish the following goals: (1) to become an expert in patient-oriented research in psychiatric neuroimaging; (2) to conduct experimental investigations of neurobiological correlates in patients with psychosis; (3) to implement revolutionary individual-level functional mapping techniques in clinical studies; and (4) to develop an independent clinical research career. To achieve these goals, Dr. Wang has assembled a mentoring team comprised of three mentors: Dr. Dost Öngür, Chief of the McLean Hospital Psychotic Disorders Division, who leads a neuroimaging laboratory studying the biology of psychotic illness; Dr. Randy Buckner, Professor of Psychology and Neuroscience at Harvard University and Director of Psychiatric Neuroimaging at Massachusetts General Hospital, one of the pioneers in functional MRI research; and Dr. Suzanne Haber, Professor of Pharmacology and Physiology at the University of Rochester, a leading scientist in the field of neuroanatomy. In addition, Dr. Hesheng Liu, Associate Professor of Radiology at Harvard Medical School and a computational neuroscientist with expertise in functional imaging, will collaborate on this project. Dr. Wang will engage in multiple career development activities to expand her ability to develop mechanistic insights about psychiatric disorders. These include new training in patient-oriented experimental research, a better understanding of the psychopathology of psychosis, and a stronger grasp of neuroanatomy. She will also receive advanced training in cognitive and clinical neuroscience. Determining the disconnected neural circuits underlying psychosis has proved elusive. Dr. Wang's research project aims to reveal circuitry abnormalities in psychotic patients using a subject-specific, cross-diagnostic approach. In Aim 1, Dr. Wang will establish methods for accurately characterizing the cortical and subcortical functional connectivity networks in individual patients. In Aim 2, leveraging a cross-diagnostic cohort of psychotic patients that will be scanned using the protocol optimized for individual-level functional analyses, as well as an existing patient data set, Dr. Wang will identify and validate cortical and subcortical functional connectivity abnormalities related to the severity of psychotic symptoms. In Aim 3, Dr. Wang will investigate the temporal variations of connectivity in individual patients and reveal abnormalities in dynamic functional connectivity related to symptoms. A series of preliminary studies conducted by Dr. Wang have laid the solid foundation for each specific aim. This research will form the basis of a study for identifying the “connectivity hubs” in individual patients for potential modulation, to be proposed in an R01 grant application before the end of the K award.

摘要

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits.

DOI：
10.1002/ana.25906
发表时间：
2020-12
期刊：
Annals of neurology
影响因子：
11.2
作者：
Shen L;Jiang C;Hubbard CS;Ren J;He C;Wang D;Dahmani L;Guo Y;Liu Y;Xu S;Meng F;Zhang J;Liu H;Li L
通讯作者：
Li L

Personalized fMRI Delineates Functional Regions Preserved within Brain Tumors.

DOI：
10.1002/ana.26303
发表时间：
2022-03
期刊：
ANNALS OF NEUROLOGY
影响因子：
11.2
作者：
Cui, Weigang;Wang, Yinyan;Ren, Jianxun;Hubbard, Catherine S.;Fu, Xiaoxuan;Fang, Shengyu;Wang, Danhong;Zhang, Hao;Li, Yang;Li, Luming;Jiang, Tao;Liu, Hesheng
通讯作者：
Liu, Hesheng

Individual-Specific Analysis for Psychoradiology.

DOI：
10.1016/j.nic.2019.09.003
发表时间：
2020-02
期刊：
Neuroimaging clinics of North America
影响因子：
2.3
作者：
Hesheng Liu;William J Liu;Danhong Wang;L. Dahmani
通讯作者：
Hesheng Liu;William J Liu;Danhong Wang;L. Dahmani

Use of an Individual-Level Approach to Identify Cortical Connectivity Biomarkers in Obsessive-Compulsive Disorder.

DOI：
10.1016/j.bpsc.2018.07.014
发表时间：
2019-01
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
0
作者：
Brennan BP;Wang D;Li M;Perriello C;Ren J;Elias JA;Van Kirk NP;Krompinger JW;Pope HG Jr;Haber SN;Rauch SL;Baker JT;Liu H
通讯作者：
Liu H