Develop Multiphoton Magnetic Resonance Imaging

摘要 磁共振成像(MRI)是一种不可缺少的非侵入性成像技术 医学和基础研究。今天的核磁共振成像假定为单光子激发。更具体地说，对于每个核子 自旋，单个光子伴随着产生磁共振信号的能态之间的跃迁。这个光子 必须在拉莫尔频率附近产生共振。这个项目的目标是探索和开发一个全新的班级 利用多光子激发的核磁共振成像技术。也就是说，与通常的单光子共振不同，建议的 一种利用多磁场激发多光子共振产生磁共振信号技术 频率，没有一个频率接近拉莫尔频率。只有自旋吸收的总能量必须 与Larmor频率相对应。多光子磁共振成像是一种全新的磁共振成像技术。它引入了新的 激发、编码、对比度产生和接收的灵活性。该项目将探索和开发 临床可行的多光子磁共振成像的基本硬件、脉冲序列、激发和接收技术。 如果成功，多光子磁共振将为许多新的途径铺平道路，以产生新的磁共振图像和 有益于人类健康。

Abstract Magnetic resonance imaging (MRI) is an indispensable non-invasive imaging technology for diagnostic medicine and basic research. Today’s MRI assumes single-photon excitation. More specifically, for each nuclear spin, a single photon accompanies the transition between energy states which creates MRI signal. This photon must resonate near the Larmor frequency. The goal of this project is to explore and develop an entire new class of MRI that utilizes multiphoton excitation. That is, instead of the usual single-photon resonance, the proposed technique can excite multiphoton resonances to generate signal for MRI by using multiple magnetic field frequencies, none of which are near the Larmor frequency. Only the total energy absorbed by a spin must correspond to the Larmor frequency. Multiphoton MRI is a radical new way to perform MRI. It introduces new flexibilities for excitation, encoding, contrast generation and reception. The project will explore and develop the essential hardware, pulse sequences, excitation and receiving techniques for clinically feasible multiphoton MRI. If successful, multiphoton MRI will pave the road for many new avenues to generate novel MRI images and benefit human health.