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Exploring the Latent Class Structure of Inhibition in Normal Aging

探索正常衰老过程中抑制的潜在类别结构

基本信息

批准号：
10217953
负责人：
Teal S Eich
金额：
$ 24.11万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10217953
关键词：
Affect Age Aging Alzheimer&apos s Disease Alzheimer’s disease biomarker Amyloid beta-Protein Area Behavior Behavioral Biological Markers Caring Clinical Cognition Cognitive Cognitive Science Cognitive aging Conflict (Psychology)Consensus Data Analyses Dementia Disease Elderly Environment Equation Factor Analysis Failure Foundations Goals Health Impaired cognition Individual Intervention Knowledge Lead Life Longevity Measures Memory Mental Health Mentorship Methods Modeling Morbidity - disease rate Morphology Multivariate Analysis Neuropsychological Tests Occupational Participant Pattern Performance Personal Satisfaction Prefrontal Cortex Problem Solving Process Quality of life Reading Research Research Personnel Research Training Resources Risk Role Scientist Seminal Services Source Statistical Models Structure Techniques Testing Thick Thinking Thinness Time Training Training Programs Well in self Work age group age related aging population apolipoprotein E-4 base biobehavior brain behavior brain morphology career cognitive ability cognitive change cognitive function cognitive neuroscience effective intervention executive function follow-up healthy aging improved longitudinal analysis morphometry nervous system disorder neuroimaging normal aging prevent relating to nervous system response responsible research conduct skills specific biomarkers therapy development young adult

项目摘要

PROJECT SUMMARY Deficits in cognitive functioning are considered one of the most debilitating aspects of aging, and prevent older adults from leading productive and meaningful lives. Although many changes occur over the normal course of aging, recent work in cognitive neuroscience has implicated a central role for inhibition, one of several “executive functions” that enable an individual to resist interference from task-irrelevant information in the service of goals. Deficits in inhibitory processes may have direct implications for older adults' ability to function independently in daily life, a key factor in considering institutional care. Despite work exploring age-related changes to inhibitory processes, inconsistent findings have prevented a theoretical consensus from being reached. Until the mechanisms supporting inhibitory abilities are fully understood, it will not be feasible to construct maximally effective interventions to strengthen inhibitory skills in the individuals who need these skills the most, and ultimately to promote successful cognitive aging. This K99/R00 presents a research and training program that will support the applicant on a path towards becoming an independent investigator focused on characterizing inhibitory processes in cognitively “normal” aging (i.e., aging in the absence of dementia or neurologic disorder). Cross-sectional and longitudinal structural equation models will test relationships between age, inhibitory ability, biomarkers for Alzheimer's Disease (AD), global and domain specific measures of cognition, and quantified measures of cortical thickness. The activities in this application will supplement the candidate's strong existing background in cognitive psychology and cognitive neuroscience and are set in a resource-rich environment that will provide the applicant with expertise in (1) structural equation modeling, (2) neuroimaging data analysis of cortical thickness in an aged population and multivariate brain-behavior analysis techniques, (3) biomarkers for age-related neuropathological disorders including AD and 4) the responsible conduct of research. The combination of the environment, training plan, research strategy and mentorship team will not only provide the candidate with a spectrum of new methods and skills that will establish her as an independent research scientist, but will also produce a body of knowledge that will clarify how inhibitory processes are affected in aging. This knowledge, in turn, may lead to targets for interventions aimed at reducing age-related cognitive morbidity and improving quality of life in the rapidly expanding U.S. aging population.

项目摘要认知功能的缺陷被认为是衰老最令人衰弱的方面之一，让成年人过上有意义的生活。虽然在正常的过程中会发生许多变化，随着年龄的增长，认知神经科学的最新研究表明，抑制作用在衰老中起着核心作用， “执行功能”，使个体能够抵抗来自任务无关信息的干扰，服务目标。抑制过程的缺陷可能对老年人的功能有直接影响在日常生活中独立，这是考虑机构护理的一个关键因素。尽管研究与年龄有关的由于抑制过程的变化，不一致的发现阻止了理论上的共识，达到了在支持抑制能力的机制被完全理解之前，构建最有效的干预措施，以加强需要这些技能的个人的抑制技能最重要的是，最终促进成功的认知老化。这个K99/R 00提出了一个研究和培训计划，将支持申请人的道路上，成为一名独立的研究者，专注于描述认知“正常”的抑制过程。老化（即，在没有痴呆或神经障碍的情况下的衰老）。横截面和纵向结构方程模型将测试年龄、抑制能力、阿尔茨海默病（AD）的生物标志物认知的全局和域特定测量，以及皮质厚度的量化测量。的活动将补充候选人在认知心理学方面的强大现有背景，认知神经科学，并设置在一个资源丰富的环境，将为申请人提供专业知识在（1）结构方程建模，（2）老年人群中皮质厚度的神经成像数据分析中和多变量脑行为分析技术;（3）年龄相关神经病理性疾病的生物标志物包括广告和4）负责任的研究行为。环境、培训计划、研究策略和导师团队不仅将为候选人提供一系列新方法和技能，这将使她成为一名独立的研究科学家，但也将产生一批这些知识将阐明抑制过程在衰老过程中是如何受到影响的。这种知识反过来可能导致旨在降低老年人与年龄有关的认知发病率和提高老年人生活质量的干预措施的目标美国老龄化人口迅速增加。