TR&D3-SCH

TR&D3 -项目概要/摘要 磁场强度的显著增加总是导致科学领域的新前沿 通过NMR光谱法可接近。通常，挑战和被视为缺点的东西， 高电场已经证明了它们的一些最大优点。串联混合（SCH）磁体，在 将于2016年夏天在NHMFL投入使用的36 T场将提供对 未来的核磁共振光谱;未来的高温超导（HTS）磁体将有 使当前低温超导（LTS）磁体的场强加倍的潜力。的 SCH磁体是具有13 T的外部超导线圈和内部Bitter板堆叠的混合磁体 其将由14 MW供电，并由以1700加仑/分钟流过堆的去离子水冷却。 SCH磁体将是迄今为止均匀性和稳定性最高的电阻磁体。 构造，但均匀性和稳定性将与LTS磁体不同。BTRR将 通过开发其他技术，利用 致力于开发和推动核磁共振光谱学科学前沿的科学家们在 磁场强度比世界上任何其他NMR光谱仪都高出50%以上。 十多年的努力现在已经投入到开发新技术，以提高稳定性和 这是磁铁的特性。目前正在采取两种方法：第一，已经开发出一种先进的锁定单元 由布鲁克和测试在NHMFL，其次，教授杰弗里Schiano从宾夕法尼亚州立大学已经制定了一个 利用感应拾波线圈和NMR的级联磁场调节技术 测量以提供反馈场校正。新的1H检测HXY 1.3 mm MAS探头将在 固体核磁共振技术的发展。1H探测有可能彻底改变固态 核磁共振的方式与30年前1H检测革命性地改变了溶液核磁共振的方式大致相同。这场革命将开启 将促进脂质双层中膜蛋白的结构表征， 细胞膜这项技术将与定向样品ssNMR相结合， 补充结构性限制。 自旋1/2核的每单位光谱仪时间的信噪比用大约B 03改善，但是 对于四极核，由于各种各样的因素， 松弛效应虽然在生物系统中有许多奇数半四极核， 最重要的是17 O。氧原子是生物大分子中催化和还原的主要位点， 功能化学这项工作的一个目标是把发展17 O光谱作为一项常规工作 光谱分析工具

TR&D3 - Project Summary/Abstract Significant increases in field strength have always led to new frontiers in the scientific arenas approachable by NMR spectroscopy. Often the challenges and what has been viewed as the drawbacks to high fields have proven to some of their greatest advantages. The Series Connected Hybrid (SCH) magnet, at a field of 36T, that will become operational in the summer of 2016 at the NHMFL will provide a view into the future for NMR spectroscopy; a future in which High Temperature Superconducting (HTS) magnets will have the potential for doubling the field strengths of current Low-Temperature superconducting (LTS) magnets. The SCH magnet is a hybrid magnet having an outer superconducting coil of 13T and inner stacks of Bitter plates that will be powered by 14MW and cooled by deionized water flowing through the stacks at 1700 gal/min. The SCH magnet will be the highest homogeneity and the highest stability resistive magnet that has been constructed, but the homogeneity and stability will not be the same as that for LTS magnets. The BTRR will develop a biomedical research focus on this magnet through the development of additional technology using a cross section of scientists committed to developing and pushing the scientific frontiers of NMR spectroscopy at a field strength that is more than 50% higher than any other NMR spectrometer in the world. More than a decade of effort has now gone into developing new technologies to enhance the stability and homogeneity of this magnet. Two approaches are being taken: first, an advanced lock unit has been developed by Bruker and tested at the NHMFL and secondly, Prof. Jeffrey Schiano from Penn State has developed a cascade field regulation technology that takes advantage of an inductive pickup coil as well as NMR measurements to provide a feedback field correction. A new 1H detection HXY 1.3 mm MAS probe will be developed for structural biology solid state NMR. 1H detection has the potential to revolutionize solid state NMR in much the same way 1H detection revolutionized solution NMR 30 years ago. This revolution will open will facilitate the structural characterization of membrane proteins in lipid bilayers and potentially in native cellular membrane. This technology will be coupled with oriented samples ssNMR that provides complementary structural restraints. The signal to noise per unit of spectrometer time for spin ½ nuclei improves with approximately B03, but for quadrupolar nuclei the rate of enhancement can be even greater due to a wide variety of factors including relaxation effects. While there are many odd halves quadrupolar nuclei in biological systems the most common and important one is 17O. Oxygen atoms are the primary sites in biological macromolecules of catalytic and functional chemistry. A goal in this effort is to work toward developing 17O spectroscopy as a routine spectroscopic tool.