Evaluating Cumulative Environmental Exposure to Metals and Non-metals and Community-level Health Using Geospatial Modeling and Personal Exposure Assessment

项目摘要 实践传统陆地文化的社区与环境密切相关，因为 文化、精神和传统习俗。虽然我们中心之前的工作证明了不同程度的 纳瓦霍民族、夏延河苏族(CRST)和阿普萨鲁克(Crow)成员的金属暴露情况， 单一的接触途径(如水)调查不足以解释个人水平的接触和 不利的健康后果。此外，关于其他化学品接触来源的知识仍然有限。 突出在部落土地上，如焚烧垃圾，可能导致微塑料、挥发性和 环境中的半挥发性化合物，并导致人体暴露。这项研究项目将解决 通过组合建模为原住民社区整合多条曝光途径的挑战 潜在的环境暴露。我们将采用现有的基于地理信息系统的多准则决策分析 一种可以整合我们小组以前使用的空气、水和土壤路径的方法。我们的模特 框架支持集成有关微塑料和其他化学品的新型土壤、水、空气和植物数据 由低温垃圾焚烧产生。这种研究方法具有创新性，因为它 调查部落土地上的联合暴露，包括微塑料和焚烧塑料副产品 在高金属曝光率的背景下。我们将(1)开发预测和验证相结合 基于考虑化学物质的多准则决策分析的环境暴露模型 来源、地形、基础设施和土地利用实践；(2)地面实况模型预测 对人和文化资源(如牲畜和植物)的综合暴露的计量 硅胶腕带、人体生物监测和免疫学研究；以及(3)收集社区规模的健康 开始评估暴露的调查数据：疾病关系(例如，癌症、自身免疫和 心血管疾病)与RP3合作。SA1将产生第一个组合的环境 Apsaáloke(Crow)和Crow和CRST保留地的曝光空间产品和精炼产品 对于NN。这些空间产品将支持部落社区的环境健康研究， 为政策制定者提供解决部落健康差距的关键信息。SA2中建议的研究 通过个人级别的化学和免疫提供基于地理信息系统的模型的重要地面事实 标记尺寸。这将使政策制定者了解综合环境保护的范围和程度 并使我们能够考虑综合化学品暴露对环境的影响 我们在这些社区的参与者样本中观察到的与金属的联系。健康 调查数据将提供数据，以验证和证实个人社区规模的健康差距 部落社区伙伴，并且与我们模型中的组合暴露预测尺度一致。

Project Summary Communities that practice traditional land-based cultures are intimately connected to the environment due to cultural, spiritual, and traditional practices. While our Center’s previous work demonstrated varying degrees of metal exposure among members of Navajo Nation, Cheyenne River Sioux (CRST) and Apsaálooke (Crow), single exposure pathway (e.g. water) investigations were not sufficient to explain individual-level exposure and adverse health outcomes. Moreover, there remains limited knowledge on other chemical exposure sources prominent on Tribal lands, such as trash burning, that may lead to accumulation of microplastics, volatile, and semi-volatile compounds in the environment and lead human exposures. This research project will address the challenge of integrating multiple exposure routes for Native communities through modeling combined environmental exposure potential. We will adapt an existing GIS-based multi-criteria decision analysis approach that can integrate air, water, and soil pathways previously used by our group. Our modeling framework enables integration of novel soil, water, air, and plant data on microplastics and other chemicals produced by low-temperature trashing combustion. This research approach is innovative because it investigates combined exposures on tribal lands, including microplastics and combusted plastic by-products against a background of high metal exposures. We will (1) develop predictive and validate combined environmental exposure models based on GIS-based multi-criteria decision analysis, which considers chemical sources, topography, infrastructure, and land-use practices; (2) ground truth model predictions through measurement of combined exposures for people and cultural resources (such as livestock and plants) using silicone wristbands, human biomonitoring, and immunology studies; and (3) collect community-scale health survey data to begin assessing exposure :disease relationships (e.g., cancer, autoimmunity, and cardiovascular disease) in collaboration with RP3. SA1 will generate the first combined environmental exposure spatial products for Apsaálooke (Crow) and Crow and CRST reservation lands and a refined product for NN. These spatial products will support environmental health research among Tribal communities and provide policy-makers with critical information to address Tribal health disparities. The studies proposed in SA2 provide important ground truthing of the GIS-based model through individual-level chemical and immune marker measurements. This will inform policy makers about the scope and extent of combined environmental exposures in their communities and allow us to consider the contributions of combined chemical exposures to associations with metals that we have observed in participant samples from these communities. The health survey data will provide data to validate and substantiate health disparities at individual community scale for tribal community partners, and at a scale consistent with the combined exposure prediction scale in our model.