Evaluating Cumulative Environmental Exposure to Metals and Non-metals and Community-level Health Using Geospatial Modeling and Personal Exposure Assessment

使用地理空间建​​模和个人暴露评估评估金属和非金属的累积环境暴露以及社区层面的健康

• 批准号: 10372186
• 负责人: Joseph Hamilton Hoover
• 金额: $ 28.02万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10372186
• 关键词: Address; Air; Animals; Area; Autoimmunity; Biological Monitoring; Cardiovascular Diseases; Chemical Exposure; Chemicals; Cheyenne; Chronic Disease; Collaborations; Communities; Complex; Data; Decision Analysis; Development; Diet; Disease; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Exposure to; Gases; Goals; Health; Health Status; Health Surveys; Human; Immune; Immune response; Immunologic Markers; Immunologics; Immunology; Individual; Information Dissemination; Infrastructure; Ingestion; Inhalation; Investigation; Knowledge; Lead; Livestock; Malignant Neoplasms; Measurement; Metal exposure; Metals; Modeling; Movement; Native Americans; Navajo; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Persons; Pesticides; Pilot Projects; Plant Oils; Plants; Policy Maker; Population; Power Plants; Process; Production; Reporting; Research; Research Project Grants; Reservations; Resources; Risk; Rivers; Sampling; Silicones; Sioux Indians; Site; Soil; Source; Statistical Methods; Statistical Models; Testing; Uncertainty; Uranium; Water; Work; base; chemical release; cold temperature; contaminated water; experience; exposed human population; exposure pathway; exposure route; health disparity; health equity; improved; innovation; land use; member; novel; predictive modeling; response; tribal community; tribal health; tribal lands; wasting

Project Summary Communities that practice traditional land-based cultures are intimately connected to the environment due to cultural, spiritual, and traditional practices. While our Center’s previous work demonstrated varying degrees of metal exposure among members of Navajo Nation, Cheyenne River Sioux (CRST) and Apsaálooke (Crow), single exposure pathway (e.g. water) investigations were not sufficient to explain individual-level exposure and adverse health outcomes. Moreover, there remains limited knowledge on other chemical exposure sources prominent on Tribal lands, such as trash burning, that may lead to accumulation of microplastics, volatile, and semi-volatile compounds in the environment and lead human exposures. This research project will address the challenge of integrating multiple exposure routes for Native communities through modeling combined environmental exposure potential. We will adapt an existing GIS-based multi-criteria decision analysis approach that can integrate air, water, and soil pathways previously used by our group. Our modeling framework enables integration of novel soil, water, air, and plant data on microplastics and other chemicals produced by low-temperature trashing combustion. This research approach is innovative because it investigates combined exposures on tribal lands, including microplastics and combusted plastic by-products against a background of high metal exposures. We will (1) develop predictive and validate combined environmental exposure models based on GIS-based multi-criteria decision analysis, which considers chemical sources, topography, infrastructure, and land-use practices; (2) ground truth model predictions through measurement of combined exposures for people and cultural resources (such as livestock and plants) using silicone wristbands, human biomonitoring, and immunology studies; and (3) collect community-scale health survey data to begin assessing exposure :disease relationships (e.g., cancer, autoimmunity, and cardiovascular disease) in collaboration with RP3. SA1 will generate the first combined environmental exposure spatial products for Apsaálooke (Crow) and Crow and CRST reservation lands and a refined product for NN. These spatial products will support environmental health research among Tribal communities and provide policy-makers with critical information to address Tribal health disparities. The studies proposed in SA2 provide important ground truthing of the GIS-based model through individual-level chemical and immune marker measurements. This will inform policy makers about the scope and extent of combined environmental exposures in their communities and allow us to consider the contributions of combined chemical exposures to associations with metals that we have observed in participant samples from these communities. The health survey data will provide data to validate and substantiate health disparities at individual community scale for tribal community partners, and at a scale consistent with the combined exposure prediction scale in our model.

项目摘要 实践传统陆地文化的社区与环境密切相关， 文化、精神和传统习俗。虽然我们中心以前的工作表明了不同程度的 纳瓦霍族、夏延河苏族（CRST）和Apsaálooke（Crow）成员的金属暴露， 单一接触途径（如水）调查不足以解释个人水平的接触， 不良健康后果。此外，对其他化学品接触源的了解仍然有限 在部落土地上突出，如垃圾焚烧，这可能导致微塑料，挥发性， 环境中的半挥发性化合物和人体接触铅。该研究项目将解决 通过结合建模来整合土著社区的多种暴露途径的挑战 环境暴露潜力。我们将采用现有的基于GIS的多准则决策分析 这种方法可以整合我们小组以前使用的空气、水和土壤途径。我们的建模 该框架能够整合有关微塑料和其他化学品的新土壤、水、空气和植物数据 由低温垃圾燃烧产生。这种研究方法是创新的，因为它 调查部落土地上的综合暴露，包括微塑料和燃烧的塑料副产品 在高金属暴露的背景下。我们将（1）开发预测和验证组合 基于GIS的多准则决策分析的环境暴露模型，其中考虑了化学 来源、地形、基础设施和土地使用实践;（2）地面实况模型预测， 测量人类和文化资源（如牲畜和植物）的综合暴露， 硅胶腕带，人体生物监测和免疫学研究;（3）收集社区规模的健康 开始评估暴露的调查数据：疾病关系（例如，癌症，自身免疫， 心血管疾病）与RP 3合作。SA 1将产生第一个组合环境 Apsaálooke（Crow）和Crow以及CRST保留地的暴露空间产品和一个改进产品 对于NN。这些空间产品将支持部落社区的环境健康研究， 为决策者提供关键信息，以解决部落健康差距。SA 2中提议的研究 通过个体水平的化学和免疫， 标记测量。这将使决策者了解综合环境影响的范围和程度。 暴露在他们的社区，使我们能够考虑的贡献， 我们在这些社区的参与者样本中观察到的与金属的联系。健康 调查数据将提供数据，以验证和证实个别社区规模的健康差距， 部落社区合作伙伴，并在一个规模一致的组合暴露预测规模在我们的模型。