PFAS Exposure and Health Effects in El Paso County, Colorado

科罗拉多州埃尔帕索县的 PFAS 暴露和健康影响

• 批准号: 10220758
• 负责人: JOHN L. ADGATE
• 金额: $ 100万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220758
• 关键词: PFAS; Exposure; Health; Effects; El

Project Summary/Abstract The overall goal of this research is to quantify the cross-sectional associations between measured and modeled perfluoroalkyl and polyfluoroalkyl substances (PFAS) in highly exposed adults and children and selected health outcomes, including lipids, kidney function, liver function, thyroid hormones and sex hormones, glucose and insulin parameters, markers of immune function, and neurobehavioral outcomes in children. We will enroll 1,000 adults and 400 children from a community in El Paso County, Colorado who experienced high levels of PFAS contamination of their municipal drinking water and private wells resulting from the use of aqueous film-forming foams (AFFF) for firefighting activities at a nearly US Air Force Base. Exposure to PFAS will be assessed via measured serum concentrations and through a detailed model to reconstruct historical PFAS concentrations in groundwater and drinking water in El Paso County. Combining this information with individual residential histories, we will be able to estimate cumulative lifetime exposure to AFFF-related PFAS in El Paso County for each study participant. Our research team is well qualified to achieve this goal due to our complementary expertise in exposure science (Adgate), environmental epidemiology (Starling), PFAS chemistry and drinking water exposure (Higgins, Vestergren), groundwater modeling (Singha, McCray), neurobehavioral testing (Wilkening), cancer epidemiology (Cockburn), statistical methods for the analysis of observational data (Glueck), and community outreach and education (Richardson, Celico). We have conducted a pilot study in El Paso County that demonstrates the feasibility of recruiting participants to complete study procedures similar to those in the ATSDR protocol. The preliminary results of our pilot study show: (1) a unique AFFF-related exposure profile with median concentrations of perfluorohexane sulfonate (PFHxS) more than ten times the median of the general US population, and (2) prominent differences in AFFF-related PFAS exposure by geographic area with an apparent north-south gradient in serum concentrations within El Paso County. In addition to the common core protocol, we propose two investigator-initiated aims: (1) a highly innovative examination of the association between PFAS and biomarkers linked to testicular and thyroid cancer risk (both previously identified in human and animal studies as potentially related to PFAS exposure), and (2) the application of novel statistical methods to estimate the combined effect of exposure to the complex mixture of PFAS found in AFFF-contaminated drinking water, and to separate the effects of individual PFAS from the correlated mixture. This research fills an important knowledge gap because populations in numerous US states have been exposed to AFFF-derived PFAS via contaminated drinking water. The completion of these aims will provide essential information for communities, researchers, and policymakers seeking to understand the health risks associated with this emerging PFAS exposure profile.

项目摘要/摘要 这项研究的总体目标是量化被测量的和被测量的 模拟的全氟烷基和多氟烷基物质(PFAS)在高度暴露的成人和儿童和 选定的健康结果，包括血脂、肾功能、肝功能、甲状腺激素和性激素， 儿童的血糖和胰岛素参数、免疫功能标记物和神经行为结果。我们 将从科罗拉多州埃尔帕索县的一个社区招募1000名成年人和400名儿童，他们经历了 他们的城市饮用水和私人水井因使用 用于近美国空军基地消防活动的水性成膜泡沫(AFFF)。暴露于全氟辛烷磺酸 将通过测量的血清浓度和通过详细的模型来重建历史 埃尔帕索县地下水和饮用水中全氟辛烷磺酸浓度。将此信息与 个人居住历史，我们将能够估计与AFFF相关的PFAS的累积终身暴露 在埃尔帕索县为每个研究参与者。我们的研究团队完全有资格实现这个目标，因为我们的 接触科学(Adgate)、环境流行病学(Starling)、全氟辛烷磺酸(PFAS)方面的互补专业知识 化学和饮用水暴露(希金斯，维斯特格伦)，地下水建模(辛哈，麦克雷)， 神经行为测试(Wilkning)，癌症流行病学(Cockburn)，分析的统计方法 观测数据(Glueck)，以及社区推广和教育(Richardson，Celico)。我们已经进行了 埃尔帕索县的一项试点研究，证明了招募参与者完成研究的可行性 程序类似于ATSDR议定书中的程序。我们的初步研究结果表明：(1)一种独特的 全氟己烷磺酸盐(PFHxS)中位数浓度大于 是美国总人口中位数的十倍，以及(2)与AFFF相关的PFAS的显著差异 埃尔帕索市内血清浓度存在明显南北梯度的地理区域暴露 县里。除了共同的核心协议之外，我们还提出了两个由研究人员发起的目标：(1)高度 对PFAS与与睾丸和甲状腺相关的生物标记物之间关系的创新性检查 癌症风险(之前在人类和动物研究中都被确定为可能与全氟辛烷磺酸接触有关)， 以及(2)应用新的统计方法来估计接触该复合体的综合效应 在受AFFF污染的饮用水中发现的全氟辛烷磺酸混合物，并分离单独的全氟辛烷磺酸的影响 从相关混合物中分离出来。这项研究填补了一个重要的知识空白，因为 美国各州已经通过受污染的饮用水暴露于AFFF衍生的全氟辛烷磺酸。完成 这些目标将为社区、研究人员和政策制定者提供必要的信息 了解与这种新出现的全氟辛烷磺酸暴露情况相关的健康风险。