Pennsylvania: Multi-Site Study of the Health Implications of Exposure to PFAS-Contaminated Drinking Water

宾夕法尼亚州：接触 PFAS 污染饮用水对健康影响的多地点研究

• 批准号: 10441051
• 负责人: Linda Morris Brown
• 金额: $ 100万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441051
• 关键词: Pennsylvania; Multi; Site; Study; Health

PROJECT SUMMARY/ABSTRACT A former Naval Air Warfare Center in Warminster Township, Bucks County, PA, and the Horsham Air Guard Station in Horsham Township, Montgomery County, PA, have been found to be the source of widespread drinking water contamination from per- and polyfluoroalkyl substances (PFAS) that went undetected for decades. Drinking water contamination was attributed to use of PFAS-containing aqueous film-forming foam (AFFF), a fire suppressant used in military training exercises. The PA site is characterized by high magnitude, long duration, and wide-ranging exposure. RTI International, the PA Department of Health (DOH), Brown University, and Temple University propose to jointly conduct research at the PA site as part of ATSDR's multisite study. The proposed site is densely populated (>80,000) and has verified perfluorooctane sulfonate and perfluorooctanoic acid contamination in public water systems (PWS) and private wells. Eligible adults and children ages 4–17 will have been exposed in the last 15 years. Adults occupationally exposed to PFAS in chemical manufacture, as a firefighter, or during fire training exercises using AFFF, will be excluded from the study. Likewise, children whose birth mothers were occupationally exposed will not be eligible. A two-stage clustered sampling design will be employed, with households selected in the first stage, followed by the sampling of all adults and children in households. Consistent with findings from a pilot biomonitoring effort conducted by PA DOH, residences served by PWS closest to the two military bases had higher serum PFAS levels and will be oversampled. A total of 2,000 adults and 800 children will be recruited for participation in the study and will complete ATSDR's core protocol, including consenting and interviewing, anthropometric measurements, neurobehavioral assessments, and biospecimen (blood and urine) collection. In addition to collecting core data on 2,800 participants, historical water reconstruction of PFAS concentrations in drinking water around the site will be conducted. Pharmacokinetic modeling will be conducted to estimate historical serum concentrations of nonoccupational-exposed people. Two investigator- initiated research activities are also proposed. First, advanced spatial analysis methods will be applied to model PFAS exposure and other potential cancer determinants over time in relation to a range of cancer endpoints. Second, exposure estimates will be leveraged to conduct a focused investigation of kidney and thyroid cancers using a family-based design. The inclusion of the PA site and the investigator-initiated research proposed in this application will contribute significantly to the scope and rigor of ATSDR's multisite PFAS environmental health study.

项目摘要/摘要 宾夕法尼亚州雄鹿县的沃林斯特镇的前海军空战中心和霍舍姆航空警卫队 宾夕法尼亚州蒙哥马利县霍舍姆镇的站被发现是宽度的来源 未发现的饮用水污染（PFAS）（PFA） 几十年。饮用水污染归因于使用含PFA的水性膜形成泡沫 （AFFF），一种用于军事训练演习的抑制剂。 PA站点的特征是高 大小，持续时间和大范围的暴露。 RTI International，PA卫生部 （DOH），布朗大学和坦普尔大学的建议，旨在在PA地点共同进行研究 ATSDR的多站点研究。所提出的地点不足（> 80,000），并已验证了perfluoroctane 公共供水系统（PWS）和私人井中的磺酸盐和全氟辛酸污染。有资格的 在过去的15年中，年龄在4-17岁的成年人和儿童将暴露。成年人暴露于 化学制造中的PFA作为消防员或使用AFFF的消防训练期间的PFA被排除在外 从研究。同样，出生母亲被占领的孩子也不符合资格。一个 将进行两阶段聚类的抽样设计，在第一阶段中选择家庭，然后选择 通过对家庭中所有成年人和儿童的取样。与飞行员生物监测的发现一致 PA DOH进行的努力，最接近两个军事基地的PW服务的住宅具有更高的连续性 PFA级别，将被过采样。共有2,000名成人和800名儿童将被招募 参与研究，并将完成ATSDR的核心协议，包括同意和面试， 人体测量值，神经行为评估和生物环境（血液和尿液）收集。 除了收集2800名参与者的核心数据外，PFA的历史水重建 将进行现场饮用水的浓度。药代动力学建模将是 进行估计非占领的人的历史血清浓度。两个调查员 - 还提出了开始的研究活动。首先，高级空间分析方法将应用于 模型PFAS暴露和其他潜在癌症决定了与一系列癌症有关的随着时间的推移 端点。其次，将利用暴露估计来对肾脏和 甲状腺癌使用基于家庭的设计。 PA站点和研究人员发起的包含 本应用程序中提出的研究将对ATSDR的多站点的范围和严格产生重大贡献 PFAS环境健康研究。