PFAS Exposure and Thyroid Related Health Outcomes in Communities along the Cape Fear River, NC

北卡罗来纳州开普菲尔河沿岸社区的 PFAS 暴露与甲状腺相关健康结果

• 批准号: 10559561
• 负责人: JANE HOPPIN
• 金额: $ 34.51万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-03 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559561
• 关键词: Address; Adult; Affect; Age; Aging; Air; Antibodies; Back; Biological; Biomedical Research; Blood; Blood specimen; Body mass index; Characteristics; Chemicals; Child; Cholesterol; Clinic Visits; Clinical; Communication; Communities; Complex; Complex Mixtures; Data; Data Set; Development; Ensure; Excretory function; Exposure to; Fright; Future; Gender; Health; Health Personnel; Heart Rate; Human; Individual; Life; Life Cycle Stages; Measures; Medical; Metabolic; Metabolism; Nafion; North Carolina; Obesity; Oral cavity; Outcome; Participant; Pattern; Persons; Plants; Poly-fluoroalkyl substances; Population; Population Heterogeneity; Pregnant Women; Privatization; Protocols documentation; Public Health; Questionnaires; Recording of previous events; Regulation; Reporting; Research Personnel; Research Project Grants; Sample Size; Sampling; Sentinel; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Time; Toxicokinetics; United States; Universities; Urine; Variant; Water; Water Pollutants; Weight; Work; age group; cohort; community living; community partnership; community science; drinking water; insight; manufacturing facility; meetings; predictive modeling; prospective; racial diversity; reconstruction; recruit; superfund site; thyroid disruption

ABSTRACT (Biomedical Research) Research Project 1 Project 1 is one of two Biomedical Research (BMR) Projects for the proposed “Center for Environmental and Health Effects of PFAS” being led by North Carolina State University (NC State). Per- and polyfluoroalkyl substances (PFAS) are common drinking water contaminants in NC and around the United States. Little is known about how long these chemicals stay in the body or what the human health impacts are. These chemicals have been detected in the drinking water of communities living along the Cape Fear River in NC. Working with three community groups along the Cape Fear River, we will evaluate PFAS exposure and thyroid health effects to people whose drinking water has been contaminated with PFAS. Disruption of thyroid hormones as well as metabolic outcomes such as obesity have been associated with PFAS in other populations. The three communities have exposure to different types of PFAS in their drinking water. Pittsboro, located on the Haw River in the upper region of the Cape Fear River basin, is exposed to historically used PFAS as a result of upstream use of firefighting foam, wastewater discharges, and land application of biosolids. The Fayetteville private well community is located near a fluorochemical plant that discharged PFAS to both air and water (Cape Fear River) since 1980; their wells are believed to be contaminated as a result of air transport. Wilmington, at the mouth of the Cape Fear River and downstream of the chemical plant, is exposed to both historically used PFAS (e.g., PFOA, PFOS) as well as a number of newly identified PFAS (e.g., GenX, Nafion byproduct 2). To study these diverse communities, we plan to recruit 1,200 individuals in the region (300 from Pittsboro, 200 from the Fayetteville private well community, and 700 from Wilmington) to evaluate how PFAS levels change over time, whether personal characteristics influence PFAS level as well as excretion from the body, and whether PFAS, either individually or as a group, influence thyroid outcomes. We plan to include individuals ages 6 and over who have lived in the region since July 2016. We will invite participants to clinic visits in Years 1 and 3 to collect blood and urine samples for PFAS and clinical analyses, administer questionnaires to obtain information on water use history, demographic characteristics, and medical and health outcomes. Working with our community partners, we will report back individual and community-level results on a regular basis. We will have Community Science Advisory Boards in each community to provide input to the study and ensure that the study investigators are well informed about community concerns. We anticipate finding PFAS mixtures in each community; we will use statistical approaches that allow us to evaluate individual PFAS while taking into account the complex mixture present. This study, with its complex mix of PFAS and racially diverse sample, will provide key insights to the human health implications of PFAS both in NC and around the world.

抽象的 （生物医学研究）研究项目1 项目 1 是拟议的“环境与环境中心”的两个生物医学研究 (BMR) 项目之一 PFAS 的健康影响”由北卡罗来纳州立大学（北卡罗来纳州）牵头。全氟烷基和多氟烷基 物质 (PFAS) 是北卡罗来纳州和美国各地常见的饮用水污染物。鲜为人知 这些化学物质在体内停留的时间或对人类健康的影响是什么。这些化学物质具有 在北卡罗来纳州开普菲尔河沿岸社区的饮用水中检测到了这种物质。与三人一起工作 开普菲尔河沿岸的社区团体，我们将评估 PFAS 暴露和甲状腺健康影响，以 饮用水被 PFAS 污染的人。甲状腺激素的破坏以及 在其他人群中，肥胖等代谢结果与 PFAS 相关。三个 社区的饮用水中存在不同类型的 PFAS。皮茨伯勒 (Pittsboro)，位于 Haw 河畔 由于以下原因，开普菲尔河流域上游地区的河流暴露于历史上使用的 PFAS 中： 消防泡沫的上游使用、废水排放和生物固体的土地应用。费耶特维尔酒店 私人井社区位于一家氟化工厂附近，该工厂向空气和水中排放 PFAS（开普敦） 恐惧河）自 1980 年起；据信，他们的水井因航空运输而受到污染。威尔明顿，位于 开普菲尔河河口和化工厂下游，暴露于历史上使用过的 PFAS（例如 PFOA、PFOS）以及一些新发现的 PFAS（例如 GenX、Nafion 副产品 2）。到 研究这些多样化的社区，我们计划在该地区招募 1,200 人（300 人来自皮茨伯勒，200 人来自 费耶特维尔私人井社区和威尔明顿的 700 个）来评估 PFAS 水平如何变化 时间、个人特征是否影响PFAS水平以及体内的排泄，以及是否 PFAS，无论是单独还是作为整体，都会影响甲状腺结果。我们计划将 6 岁以下的个人纳入其中 调查自 2016 年 7 月以来居住在该地区的人员。我们将邀请参与者在第一年和第三年到诊所就诊， 收集血液和尿液样本进行 PFAS 和临床分析，进行问卷调查以获取信息 用水历史、人口特征以及医疗和健康结果。与我们合作 社区合作伙伴，我们将定期报告个人和社区层面的结果。我们将会有 每个社区的社区科学咨询委员会为研究提供投入并确保研究 调查人员充分了解社区关注的问题。我们预计在每个产品中都会发现 PFAS 混合物 社区;我们将使用统计方法来评估个体 PFAS，同时考虑到 存在的复杂混合物。这项研究包含 PFAS 和种族多样化样本的复杂组合，将提供 关于北卡罗来纳州和世界各地 PFAS 对人类健康影响的重要见解。